Association Study between Hypertension and A/G Polymorphism at Codon 637 of the Transporter Associated with Antigen Processing 1 Gene

Shen, Chong; Guo, Zhirong; Wu, Ming; Hu, Xiao-shu; Yang, Guang; Yu, Rongbin; Shen, Hongbing; Xu, Yaochu; Yao, Cailiang

doi:10.1291/hypres.30.683

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…Study by Soundravally et al implicated persons homozygous for valine at position TAP1 (637) were less likely to develop primary dengue hemorrhagic fever and dengue shock syndrome [19]. Studies suggested the heterozygous genotype at position 637 of TAP1 gene could be responsible for susceptibility to hypersensitivity pneumonitis in Mexican population [20] and hypertension [21]. AG polymorphism at TAP1 (637) would play an important role in functional alteration of TAP1 [21] and also was associated with risk of hepatitis B virus infection [13].…”

Section: Discussionmentioning

confidence: 99%

“…Studies suggested the heterozygous genotype at position 637 of TAP1 gene could be responsible for susceptibility to hypersensitivity pneumonitis in Mexican population [20] and hypertension [21]. AG polymorphism at TAP1 (637) would play an important role in functional alteration of TAP1 [21] and also was associated with risk of hepatitis B virus infection [13]. A similar phenomenon as TAP1 (333) could hold good for alleles at TAP1 (637) position.…”

Section: Discussionmentioning

confidence: 99%

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Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus–tuberculosis co-infection

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus–tuberculosis co-infection

et al. 2011

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“…31 Zhang et al found that rs1057141 significantly increased PTB risk (OR = 0.17, 95% CI 0.04–0.79) among people aged over 60 years, while rs1135216 was significantly associated with susceptibility to PTB in people younger than 60 years. 30 rs1135216 was also found to be associated with other diseases, such as primary dengue hemorrhagic fever and dengue shock syndrome, 46 hypersensitivity pneumonitis in the Mexican population, 47 and hypertension 48 and leprosy in the Indian population. 49 In our study, the frequency of rs1057141-C was slightly higher in the control group than in the TB group and PTB subgroup ( P =0.039 and P =0.023, respectively), which slightly reduced the risk of TB in the Yunnan Han population.…”

Section: Discussionmentioning

confidence: 94%

Transporter Associated with Antigen Processing 1 Gene Polymorphisms Increase the Susceptibility to Tuberculosis

Lu¹,

Wang²,

Liu³

et al. 2023

PGPM

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Purpose Tuberculosis (TB) is known to result from a complex interaction between the host immune response and Mycobacterium infection. The transporter associated with antigen processing (TAP) plays an important role in the processing and presentation pathways for the Mycobacterium tuberculosis ( M. tb ) antigen. To investigate the possible association of the TAP1 and TAP2 genes with TB. Patients and Methods A total of 449 TB patients and 435 control subjects were included in this study, and single nucleotide polymorphisms (SNPs) in the TAP gene, as well as TAP1 and TAP2 alleles, were genotyped. Results TAP gene association analysis of TB diseases showed that rs41551515-T in the TAP1 gene was significantly associated with susceptibility to TB ( P =7.96E-04, OR=4.124, 95% CI: 1.683–10.102), especially pulmonary TB (PTB, P =6.84E-04, OR=4.350, 95% CI: 1.727–10.945), and the combination of rs1057141-T-rs1135216-C in the TAP1 gene significantly increased the risk of TB susceptibility ( P =5.51E-05, OR=10.899, 95% CI: 2.555–46.493). Five novel TAP1 alleles were detected in Yunnan Han people, and the allele frequency of TAP1*unknown_3 (rs41555220-rs41549617-rs1057141-rs1135216-rs1057149-rs41551515: C-A-T-C-C-T) was notably increased in all TB patients, including in the PTB and EPTB subgroups, and was significantly associated with the risk of susceptibility to TB. However, no association between the TAP2 gene and TB was found in this study. Conclusion Host genetic variants of rs41551515-T and the combination rs1057141-T-rs1135216-C, as well as TAP1*unknown_3 may play a critical role in susceptibility to TB disease.

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Endocrine Disruptors Affect the Genomic Profile of the Rat Mammary Gland at Different Developmental Stages

Cicco

Santucci-Pereira

Moral

et al. 2011

Environment and Breast Cancer

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Association Study between Hypertension and A/G Polymorphism at Codon 637 of the Transporter Associated with Antigen Processing 1 Gene

Cited by 4 publications

References 39 publications

Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus–tuberculosis co-infection

Association of TAP 1 and 2 gene polymorphisms with human immunodeficiency virus–tuberculosis co-infection

Transporter Associated with Antigen Processing 1 Gene Polymorphisms Increase the Susceptibility to Tuberculosis

Endocrine Disruptors Affect the Genomic Profile of the Rat Mammary Gland at Different Developmental Stages

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