Increased mean platelet volume in patients with panic disorder

Abstract

ObjectiveThe relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD).MethodsSixty-one drug-free patients, aged 18–65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age- and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject.ResultsThe MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI.ConclusionAlterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients.

Mean platelet volume level in patients with generalized anxiety disorder

“…Results of the studies about MPV values in panic disorder patients were contradictory. Some reported that MPV values were higher in panic disorder patients [15,16] whereas others reported otherwise [14,17]. Increased MPV was attributed to activation of platelets via α-2 receptors and decreased MPV was attributed to 5-HT transporter rate and its metabolism.…”

“…Increased MPV levels are thought to be closely related to cardiovascular disorders [13]. MPV values were studied in also schizophrenia, bipolar disorder and panic disorder with contradictory and inconclusive results [14][15][16][17][18]. We could not find any study evaluating the MPV levels in GAD patients in the literature.…”

Anxiety Disorders and Cardiovascular Disease

“…In patients with PD, platelet aggregation has been shown to be elevated via changes in nitrous oxide and homocysteine levels [80]. Finally, patients with PD have larger mean platelet volume, a marker of increased platelet reactivity [81]. …”

The association between mean platelet volume levels and poststroke depression

“…Besides, high MPV levels were also observed among patients who got depression or panic disorder (Buriachkovskaia et al, 2006; Kokacya et al, 2015). It has been established that MPV was associated with higher platelet reactivity (Bath & Butterworth, 1996; van der Loo & Martin, 1999; Yetkin, 2008), which is involved in the pathophysiological mechanisms of depression (Musselman et al, 1996; Nemeroff & Musselman, 2000).…”