Increased mean platelet volume after acute myocardial infarction relates to diabetes and to cardiac failure

Hendra, T. J.; Oswald, G. A.; Yudkin, John

doi:10.1016/s0168-8227(88)80080-9

Cited by 57 publications

(41 citation statements)

References 19 publications

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“…We found a significant inverse correlation between platelet count and mean platelet volume, in agreePlatelet indices in the general population haematologica | 2011; 96 (8) 1185 [20][21][22] or platelet distribution width. This finding could be explained by the possibility that, in order to maintain constant platelet functional mass, 23 platelet count would be decreased in the presence of bigger platelets.…”

Section: Discussionsupporting

confidence: 81%

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

Santimone¹,

Castelnuovo²,

Curtis³

et al. 2011

Haematologica

155

100

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The online version of this article has a Supplementary Appendix. BackgroundThe understanding of non-genetic regulation of platelet indices -platelet count, plateletcrit, mean platelet volume, and platelet distribution width -is limited. The association of these platelet indices with a number of biochemical, environmental and clinical variables was studied in a large cohort of the general population. Design and MethodsMen and women (n=18,097, 52% women, 56±12 years) were randomly recruited from various villages in Molise (Italy) in the framework of the population-based cohort study "Moli-sani". Hemochromocytometric analyses were performed using an automatic analyzer (Beckman Coulter, IL, Milan, Italy). Associations of platelet indices with dependent variables were investigated by multivariable linear regression analysis. ResultsFull models including age, sex, body mass index, blood pressure, smoking, menopause, white and red blood cell counts, mean corpuscular volume, D-dimers, C-reactive protein, high-density lipoproteins, low-density lipoproteins, triglycerides, glucose, and drug use explained 16%, 21%, 1.9% and 4.7% of platelet count, plateletcrit, mean platelet volume and platelet distribution width variability, respectively; variables that appeared to be most strongly associated were white blood cell count, age, and sex. Platelet count, mean platelet volume and plateletcrit were positively associated with white blood cell count, while platelet distribution width was negatively associated with white blood cell count. Platelet count and plateletcrit were also positively associated with C-reactive protein and D-dimers (P<0.0001). Each of the other variables, although associated with platelet indices in a statistically significant manner, only explained less than 0.5% of their variability. Platelet indices varied across Molise villages, independently of any other platelet count determinant or characteristics of the villages. ConclusionsThe association of platelet indices with white blood cell count, C-reactive protein and Ddimers in a general population underline the relation between platelets and inflammation.Key words: platelet, inflammation, C-reactive protein, white blood cells, age, gender. Citation: Santimone I, Di Castelnuovo A, De Curtis A, Spinelli M, Cugino D, Gianfagna F, Zito F, Donati MB, Cerletti C, de Gaetano G and Iacoviello L on behalf of the Moli-sani ProjectInvestigators.White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project. Haematologica 2011;96(8):1180-1188. doi:10.3324/haematol.2011 This is an open-access paper.White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

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Section: Discussionsupporting

confidence: 81%

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

Santimone¹,

Castelnuovo²,

Curtis³

et al. 2011

Haematologica

155

100

View full text Add to dashboard Cite

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“…MPV is an indicator of the size and activity of platelets. Increased values of MPV have been shown to be a risk factor for deep venous thrombosis, acute myocardial infarction, stroke, and acute ischemic cerebrovascular events (18)(19)(20)(21) . Bath and Butterworth reported that platelet hyperactivity results in an increase in MPV (22) .…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume in patients with retinal artery occlusion

Şahin¹,

Şahin²,

Yüksel³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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RESUMO Objetivo: O objetivo deste estudo foi investigar o volume plaquetário médio (MPV) de pacientes com oclusão da artéria da retina (RAO ABSTRACTPurpose: The aim of this study was to investigate the mean platelet volume (MPV) of patients with retinal artery occlusion (RAO). Methods: Thirty-seven patients diagnosed with RAO and 32 control subjects were included in this retrospective study. Retinal artery occlusion was diagnosed on the basis of clinical examination and fundus fluorescein angiography. All participants underwent complete ocular examination, and MPV, hematocrit, hemoglobin, and platelet counts were recorded. RAO patient data were compared with those of the control subjects.Results: Patients with RAO had significantly higher MPV values (7.96 ± 1.2 fL) com pared with control subjects (7.33 ± 0.7 fL, p<0.001). No significant difference was found with regard to platelet count between the RAO group and the control group (262 ± 70.1 × 10 9 /L and 251 ± 56.6 × 10 9 /L, respectively, p=0.50). MPV was an independent predictor of RAO [odds ratio (OR)=0.50; 95% confidence interval (CI)=0.28-0.89; p=0.019). Conclusions: Our results demonstrated that MPV values were significantly higher in patients with RAO, suggesting that larger platelets may contribute to the pathogenesis of the RAOs.

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“…Increased MPV has been demonstrated in diabetes (3)(4)(5)(6)(7)(8)(9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10)(11)(12)(13)(14)(15)(16)(17), diabetic neuropathy (18)(19)(20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3)(4)(5)26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing 2012.…”

Section: Introductionmentioning

confidence: 99%

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

Güngör¹,

Gürsoy

Güngör³

et al. 2016

Turk J Med Sci

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IntroductionDiabetes mellitus (DM), a major global health problem, is commonly associated with increased risk of developing micro-and macrovascular disease. Despite its clinical importance, the pathophysiology of diabetic complications is not completely understood. Platelets have been thought to be involved in these complications. Diabetic retinopathy (DR) is one of those important complications and leads to a considerable increase in morbidity.Platelet volume is a marker of platelet activation and function that can be measured easily as mean platelet volume (MPV) by clinical analyzers. It is now known that larger platelets are more reactive and produce more prothrombotic factors (1,2). Increased MPV has been demonstrated in diabetes (3-9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10-17), diabetic neuropathy (18-20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3-5,26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing the production of more prothrombotic factors, or causing endothelium-dependent vasomotor dysfunction.Keeping in mind these complex relations between MPV, diabetes, and its complications, in the present study we aimed to: 1) compare the MPV in diabetic patients with that in healthy controls; 2) determine if there is a difference in MPV between diabetic patients with and without DR, and also with and without proliferative retinopathy; 3) compare MPV levels of diabetic patients with or without hypertension (HTA), hyperlipemia (HL), and HTA with HL, and 4) see if there is a correlation of MPV with HbA1c and body mass index (BMI) in diabetic patients. Material and methods PatientsA total of 102 type 2 DM (T2DM) patients [65 female (63.7%), 35 male (36.3%)], 50 of them without retinopathy [31 female (62.0%), 19 male (38.0%)] and 52 with retinopathy [34 female (65.4%), 18 male (34.6%)], aged 22-90 years, were recruited from the Clinic of Ankara Education and Research Hospital from June 2009 to June Background/aim: Patients with diabetes mellitus have an increased risk of developing micro-and macrovascular complications. Retinopathy is one of the most important complications of diabetes whose pathophysiological cause has not yet been determined. One candidate may be platelet volume. In this study we aimed to investigate the association between mean platelet volume and diabetic retinopathy.Materials and methods: Mean platelet volume levels were investigated in type 2 diabetic patients with and without retinopathy, and in healthy participants. After reclassifying our diabetics in terms of the presence or absence of hypertension and hyperlipidemia, we compared their mean platelet volumes. We then checked to see if the mean platelet volume correlated with hemoglobin A1c and body mass index. Results:The mean platelet volume levels were higher in all diabetic patients, and they were highest in diabetics with retinopathy. The mean plate...

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Increased mean platelet volume after acute myocardial infarction relates to diabetes and to cardiac failure

Cited by 57 publications

References 19 publications

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project

Mean platelet volume in patients with retinal artery occlusion

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

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