Increased Macrosomia and Perinatal Morbidity Independent of Maternal Obesity and Advanced Age in Korean Women With GDM

Jang, Hak Chul; Cho, Nam H.; Min, Yong Ki; Han, In K.; Jung, Kyu Byung; Metzger, Boyd E.

doi:10.2337/diacare.20.10.1582

Cited by 66 publications

(50 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the study period, 39,190 consecutive women underwent screening for GDM. We followed a previously described protocol for the screening and diagnosis of GDM [3,26]. In brief, all pregnant women without a previous diagnosis of glucose intolerance were screened for GDM between 24 and 28 weeks of gestation by using the 50 g, 1 h glucose challenge test as recommended by the Third International Workshop-Conference on GDM [1].…”

Section: Methodsmentioning

confidence: 99%

Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

et al. 2008

View full text Add to dashboard Cite

Aims/hypothesis New genetic variants associated with susceptibility to type 2 diabetes mellitus have been discovered in recent genome-wide association (GWA) studies. The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM). Methods The study included 869 Korean women with GDM and 345 female and 287 male Korean non-diabetic controls. We genotyped the single nucleotide polymorphisms (SNPs) rs7756992 and rs7754840 in CDKAL1; rs564398, rs1333040, rs10757278 and rs10811661 in the CDKN2A−CDKN2B region; rs8050136 in FTO; rs1111875, rs5015480 and rs7923837 in HHEX; rs4402960 in IGF2BP2; and rs13266634 in SLC30A8. In addition, rs7903146 and rs12255372 in TCF7L2; rs5215 and rs5219 in KCNJ11; and rs3856806 and rs1801282 in PPARG were genotyped. The genotype frequencies in the GDM patients were compared with those in the non-diabetic controls. Results Compared with controls (men and women combined), GDM was associated with rs7756992 and rs7754840 (OR 1.55, 95% CI 1.34-1.79, p=4.17×10 −9 ) in CDKAL1; rs10811661 (OR 1.49, 95% CI 1.29-1.72, p=1.05×10 −7 ) in the CDKN2A−CDKN2B region; rs1111875 (OR 1.27, 95% CI 1.09-1.49, p=0.003), rs5015480, and rs7923837 in HHEX; rs4402960 (OR 1.18, 95% CI 1.01-1.38, p=0.03) in IGF2BP2; rs13266634 (OR 1.24, 95% CI 1.07-1.43, p=0.005) in SLC30A8; and rs7903146 (OR 1.58, 95% CI 1.03-2.43, p=0.038) in TCF7L2. The risk alleles of the SNPs rs7756992 and rs7754840 in CDKAL1; rs10811661 in the CDKN2A-CDKN2B region; and rs1111875, rs5015480 and rs7923837 in HHEX were associated with significant decreases in the insulin AUC during a 100 g OGTT performed at the time of diagnosis of GDM. Conclusions/interpretation Some of the type 2 diabetesassociated genetic variants that were discovered in the recent GWA studies are also associated with GDM in Koreans.

show abstract

Section: Methodsmentioning

confidence: 99%

Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Our protocol for screening and diagnosis of GDM has been described in previous publications (13,14). Briefly, all pregnant women who had not been identified as having glucose intolerance before 24 weeks were screened for GDM between 24 and 28 weeks' gestation using the 50-g 1-h glucose challenge test.…”

Section: Research Design Andmentioning

confidence: 99%

Subsequent Pregnancy After Gestational Diabetes Mellitus

et al. 2008

View full text Add to dashboard Cite

OBJECTIVE -The purpose of this study was to determine the frequency of recurrent gestational diabetes mellitus (GDM) and to find risk factors that can predict the recurrence of GDM in Korean women with previous GDM.RESEARCH DESIGN AND METHODS -We evaluated women who had GDM in an index pregnancy (1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)) and a subsequent pregnancy by 2003. An oral glucose tolerance test (OGTT) was performed during the index pregnancy and 2 months postpartum. The recurrence rate of GDM was assessed among 111 women who had a subsequent pregnancy. Multivariate logistic regression analysis was used to identify independent predictors of recurrent GDM.RESULTS -The frequency of recurrent GDM in subsequent pregnancies was 45.0% (95% CI 35.6 -54.4%). Women with impaired fasting glucose and/or impaired glucose tolerance 2 months postpartum were at increased risk for recurrent GDM (relative risk 2.31, 95% CI 1.24 -4.30). Higher BMI before the subsequent pregnancy (P ϭ 0.024), higher fasting glucose concentration (P ϭ 0.007) 2 months postpartum, and lower 1-h insulin concentration (P ϭ 0.004) of the diagnostic OGTT in the index pregnancy were independent risk factors for recurrence of GDM in subsequent pregnancies.CONCLUSIONS -GDM recurred in nearly half of subsequent pregnancies in Korean women. Fasting glucose 2 months postpartum might be a clinically valuable predictor of recurrent GDM risk.

show abstract

“…Previous studies have indicated that mothers with GDM are more likely to present with preeclampsia, premature rupture of the membranes, shoulder dystocia, Caesarean section, and pre-term delivery than are those with normal glucose tolerance (NGT) during pregnancy [7][8][9]. The frequent occurrence of perinatal morbidities such as macrosomia, injuries of the brachial plexus, neonatal hypoglycaemia, and foetal distress in offspring also results from glucose intolerance during gestation [7].…”

Section: Introductionmentioning

confidence: 99%

Early manifestation of cardiovascular disease risk factors in offspring of mothers with previous history of gestational diabetes mellitus

Lee

Jang

Park³

et al. 2007

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

Increased Macrosomia and Perinatal Morbidity Independent of Maternal Obesity and Advanced Age in Korean Women With GDM

Abstract: Antepartum maternal glucose metabolism was significantly associated with fetal hyperinsulinemia and excessive fetal growth in relatively nonobese Korean women. These findings support a direct role for metabolic factors in the adverse outcomes in pregnancies complicated by GDM.

Cited by 66 publications

References 22 publications

Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population

Subsequent Pregnancy After Gestational Diabetes Mellitus

Early manifestation of cardiovascular disease risk factors in offspring of mothers with previous history of gestational diabetes mellitus

Contact Info

Product

Resources

About