Early manifestation of cardiovascular disease risk factors in offspring of mothers with previous history of gestational diabetes mellitus

Lee, Hoon; Jang, Hak Chul; Park, Hae K.; Cho, Nam H.

doi:10.1016/j.diabres.2007.03.023

Cited by 58 publications

(52 citation statements)

References 39 publications

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“…They also had an increased propensity to develop diabetes in adulthood (128) . More recently, studies of children exposed to maternal obesity and gestational diabetes in utero have shown higher incidence of insulin resistance (129) , heart hypertrophy (129) and CVD in later life (130,131) . The detrimental effects of overnutrition during fetal and early postnatal life have also been observed in animal models.…”

Section: Maternal Obesity and Gestational Diabetesmentioning

confidence: 99%

The impact of early nutrition on the ageing trajectory

Tarry-Adkins

Ozanne

2014

Proc. Nutr. Soc.

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Epidemiological studies, including those in identical twins, and in individuals in utero during periods of famine have provided robust evidence of strong correlations between low birthweight and subsequent risk of disease in later life, including type 2 diabetes (T2D), CVD, and metabolic syndrome. These and studies in animal models have suggested that the early environment, especially early nutrition, plays an important role in mediating these associations. The concept of early life programming is therefore widely accepted; however the molecular mechanisms by which early environmental insults can have long-term effects on a cell and consequently the metabolism of an organism in later life, are relatively unclear. So far, these mechanisms include permanent structural changes to the organ caused by suboptimal levels of an important factor during a critical developmental period, changes in gene expression caused by epigenetic modifications (including DNA methylation, histone modification and microRNA) and permanent changes in cellular ageing. Many of the conditions associated with early-life nutrition are also those which have an age-associated aetiology. Recently, a common molecular mechanism in animal models of developmental programming and epidemiological studies has been development of oxidative stress and macromolecule damage, specifically DNA damage and telomere shortening. These are phenotypes common to accelerated cellular ageing. Thus, this review will encompass epidemiological and animal models of developmental programming with specific emphasis on cellular ageing and how these could lead to potential therapeutic interventions and strategies which could combat the burden of common age-associated disease, such as T2D and CVD.

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Section: Maternal Obesity and Gestational Diabetesmentioning

confidence: 99%

The impact of early nutrition on the ageing trajectory

Tarry-Adkins

Ozanne

2014

Proc. Nutr. Soc.

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“…Two cohorts were reported twice; two papers were excluded on this basis [35,37]. Four studies were excluded because the control groups were not comparable to other studies (offspring of mothers who subsequently developed diabetes [11,23,27], and offspring of mothers with impaired glucose tolerance during pregnancy [31]). One study was excluded because the study population (preterm, low-birthweight infants [22]) was not comparable to other studies.…”

Section: Literature Searchmentioning

confidence: 99%

“…The literature search identified 94 papers, of which 19 matched the inclusion criteria [11,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] (Fig. 1).…”

Section: Literature Searchmentioning

confidence: 99%

The diabetic pregnancy and offspring blood pressure in childhood: a systematic review and meta-analysis

Aceti¹,

Santhakumaran²,

Logan³

et al. 2012

Diabetologia

110

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Aims/hypothesis Offspring of diabetic mothers have increased risk of the metabolic syndrome in adulthood. Studies examining BP in offspring of diabetic mothers have conflicting conclusions. We performed a systematic review and metaanalysis of studies reporting offspring BP in children born to diabetic mothers. Methods Citations were identified in PubMed. Authors were contacted for additional data. Systolic and diastolic BP in offspring of diabetic mothers and controls were compared. Subgroup analysis of type of maternal diabetes and offspring sex were performed. Fixed-effects models were used, and random-effects models where significant heterogeneity was present. Meta-regression was used to test the relationship between offspring systolic BP and prepregnancy BMI. Results Fifteen studies were included in the review and 13 in the meta-analysis. Systolic BP was higher in offspring of diabetic mothers (mean difference 1.88 mmHg [95% CI 0.47, 3.28]; p00.009). Offspring of mothers with gestational diabetes had similar diastolic BP to controls, but higher systolic BP (1.39 mmHg [95% CI 0.00, 2.77]; p00.05); results for type 1 diabetes were inconclusive and there were no separate data available on offspring of type 2 diabetic mothers. Male offspring of diabetic mothers had higher systolic BP (2.01 mmHg [95% CI 0.93, 3.10]; p00.0003) and diastolic BP (1.12 mmHg [95% CI 0.36, 1.88]; p00.004) than controls; in female offspring there was no difference (systolic: 0.54 mmHg [95% CI −1.83, 2.90], p00.66; diastolic: 0.51 mmHg [95% CI −1.07, 2.09], p00.52). The correlation between offspring systolic BP and maternal prepregnancy BMI was not significant (p00.37). Conclusions/interpretation Offspring of diabetic mothers have higher systolic BP than controls. Differences related to sex and type of maternal diabetes require further investigation.

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“…Gebelikte başlayan ya da ilk kez bu süreçte tanımlanan, gebelerin %3-5'inde görülen karbonhidrat intoleransıdır (1,(11)(12)(13). Bu durum anne ve fetüs sağlığıyla yakından ilişkilidir (12).…”

Section: ) Gestasyonel Diyabet (Gdm)unclassified

“…Çalışmalar GDM'li annnelerin preeklempsi, premature doğum, distazi, sezeryan doğuma normal glukoz seviyesine sahip annelere göre daha yatkın olduğunu göstermiştir. GDM'li annelerin bebeklerinde makrozomi, brakial pleksus, yenidoğan hipoglisemisi ve fetal distres sık görülür (13).…”

Section: ) Gestasyonel Diyabet (Gdm)unclassified

Türkiye florasında diyabet tedavisinde kullanılan tıbbi bitkiler

ÖNER¹

2010

Ankara Üniversitesi Eczacılık Fakültesi Dergisi

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Early manifestation of cardiovascular disease risk factors in offspring of mothers with previous history of gestational diabetes mellitus

Cited by 58 publications

References 39 publications

The impact of early nutrition on the ageing trajectory

The impact of early nutrition on the ageing trajectory

The diabetic pregnancy and offspring blood pressure in childhood: a systematic review and meta-analysis

Türkiye florasında diyabet tedavisinde kullanılan tıbbi bitkiler

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