2010
DOI: 10.1016/j.atherosclerosis.2009.11.044
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Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Δ6-desaturase knockout (6-DS KO) mice: Beneficial effects of arachidonic acid

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Cited by 28 publications
(15 citation statements)
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“…Cholesterol metabolism is closely interrelated with cardiovascular disease. As an important regulator of cholesterol homeostasis, arachidonic acid metabolism increased macrophage cholesterol 31 biosynthesis (Rosenblat et al, 2010). The increase of steroid substances and cholesterol content change of the fatty acid and arachidonic acid metabolism, thus aggravating inflammation.…”
Section: Sterol Metabolic Perturbationmentioning
confidence: 99%
“…Cholesterol metabolism is closely interrelated with cardiovascular disease. As an important regulator of cholesterol homeostasis, arachidonic acid metabolism increased macrophage cholesterol 31 biosynthesis (Rosenblat et al, 2010). The increase of steroid substances and cholesterol content change of the fatty acid and arachidonic acid metabolism, thus aggravating inflammation.…”
Section: Sterol Metabolic Perturbationmentioning
confidence: 99%
“…In macrophages, PON2 expression is increased by oxidative stress [67], and in vascular cells by endoplasmic reticulum stress modulated via an endoplasmic reticulum stress element-like sequence found to be present in the promoter region of PON2 [71]. Arachidonic acid [116], unesterified cholesterol [117], the licorice phytoestrogen glabidrin [118], and the hypocholesterolemic drug atorvastatin [119] also upregulate PON2 expression in various cell types. Urokinase plasminogen activator upregulates PON2 in macrophages via NADPH oxidase and the transcription factor SREBP-2 [120, 121], while in mouse fibroblasts dexamethasone increases PON2 mRNA levels [122].…”
Section: Pon2mentioning
confidence: 99%
“…Tissues of the D6KO mouse are deficient in EPA, DHA, and AA if these fatty acids are not provided in the diet. Previous studies have utilized the D6KO mouse to evaluate the effects of AA/EPA/DHA restriction on reproduction, macrophage activity, and intestinal and epidermal lesions (Stroud et al 2009;Rosenblat et al 2010;Roqueta-Rivera et al 2011). Additionally, the hepatic fatty acid profile of D6KO animals can be rescued to wild-type (WT) levels when D6KO animals are fed a diet containing adequate amounts of AA, EPA, and DHA (Monteiro et al 2012).…”
Section: Introductionmentioning
confidence: 98%