Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm

He, Yuchen; Xing, Jia; Wang, Shiyue; Xin, Shijie; Han, Yanshuo; Zhang, Jian

doi:10.21037/atm.2019.12.65

Cited by 60 publications

(67 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TRAMP mice developed varying degrees of prostate hyperplasia at 6-12 weeks, progressed to severe hyperplasia and adenocarcinoma at 18 weeks, and presented primary tumors at 24-30 weeks 37 . M 6 A methylation level contributes to the progression of human cancer 38 , 39 . We hypothesized that changes in m 6 A level promoted the development of PCa, thus, we detected the m 6 A levels in TRAMP mice and PCa cell lines.…”

Section: Discussionmentioning

confidence: 99%

N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer

Wu¹,

Xie²,

Huang³

et al. 2021

J. Cancer

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer

Wu¹,

Xie²,

Huang³

et al. 2021

J. Cancer

View full text Add to dashboard Cite

“…m 6 A-modified nucleotides were previously shown to be widely distributed in human tissues including the liver, kidney, brain, lung, and heart ( Dominissini et al, 2012 ; He et al, 2019 ; Lan et al, 2019 ; Mathiyalagan et al, 2019 ). Here, we detected 1.021, 1.254, and 1.176 m 6 A peaks per gene in skin samples of PP, PN, and NN, respectively.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome-Wide m6A Methylation in Skin Lesions From Patients With Psoriasis Vulgaris

Wang

Jin

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

N 6-methyladenosine (m 6 A) methylation, as the most prevalent internal RNA modification, has been revealed to play critical roles in various biological functions. In this study, we performed m 6 A transcriptome-wide profiling in three kinds of skin tissue: involved psoriatic skin (PP), uninvolved psoriatic skin (PN), and healthy control skin samples (NN). The findings revealed that transcripts of PP contained the fewest m 6 A peaks and lowest m 6 A peak density. The greatest differences of m 6 A methylation were observed in the PP vs. NN and PP vs. PN comparisons. Intriguingly, in these comparisons, hypermethylated m 6 A was mainly enriched within the CDSs and 3 UTRs, while hypomethylated m 6 A was not only enriched within CDSs and 3 UTRs, but also within 5 UTRs. GO and KEGG pathway analyses indicated that hypermethylated transcripts in PP were particularly associated with response-associated terms, cytokine production, and olfactory transduction. Meanwhile, hypomethylated transcripts in PP were mainly associated with development-related processes and the Wnt signaling pathway. In addition, we discovered that 19.3-48.4% of the differentially expressed transcripts in psoriasis vulgaris were modified by m 6 A, and that transcripts with lower expression were more preferentially modified by m 6 A. Moreover, upregulation of gene expression was often accompanied by upregulation of m 6 A methylation, suggesting a regulatory role of m 6 A in psoriasis vulgaris gene expression.

show abstract

“…The exact mechanisms contributing to AAA have not yet been elucidated. He et al first investigated the role of m 6 A modification in AAA and provided a potential epigenetic mechanism in AAA ( 96 ). They discovered that m 6 A modification significantly increased in AAA, as compared to healthy aortic tissues.…”

Section: M 6 a And Cardiovascular Diseasementioning

confidence: 99%

“…They subsequently discovered significant correlations between the m 6 A modification level and the mRNA expression level of the writers, erasers and readers, indicating a tight crosstalk among these modulators. In clinical data, a higher m 6 A level was found to be positively associated with the AAA diameter and hematological parameters ( 96 ). Hence, abnormal m 6 A modification is crucial to the occurrence and progression of AAA.…”

Section: M 6 a And Cardiovascular Diseasementioning

confidence: 99%

Role of m6A RNA methylation in cardiovascular disease (Review)

et al. 2020

View full text Add to dashboard Cite

N 6 -methyladenosine (m 6 A) is the most prevalent and abundant type of internal post-transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including mRNAs, rRNAs, tRNAs, long non-coding RNAs and microRNAs, are involved in m 6 A methylation. The biological function of m 6 A modification is dynamically and reversibly mediated by methyltransferases (writers), demethylases (erasers) and m 6 A binding proteins (readers). The methyltransferase complex is responsible for the catalyzation of m 6 A modification and is typically made up of methyltransferase-like (METTL)3, METTL14 and Wilms tumor 1-associated protein. Erasers remove methylation by fat mass and obesity-associated protein and ALKB homolog 5. Readers play a role through the recognition of m 6 A-modified targeted RNA. The YT521-B homology domain family, heterogeneous nuclear ribonucleoprotein and insulin-like growth factor 2 mRNA-binding protein serve as m 6 A readers. The m 6 A methylation on transcripts plays a pivotal role in the regulation of downstream molecular events and biological functions, such as RNA splicing, transport, stability and translatability at the post-transcriptional level. The dysregulation of m 6 A modification is associated with cancer, drug resistance, virus replication and the pluripotency of embryonic stem cells. Recently, a number of studies have identified aberrant m 6 A methylation in cardiovascular diseases (CVDs), including cardiac hypertrophy, heart failure, arterial aneurysm, vascular calcification and pulmonary hypertension. The aim of the present review article was to summarize the recent research progress on the role of m 6 A modification in CVD and give a brief perspective on its prospective applications in CVD.

show abstract

Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm

Cited by 60 publications

References 39 publications

N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer

N6-methyladenosine RNA methylation regulators contribute to the progression of prostate cancer

Transcriptome-Wide m6A Methylation in Skin Lesions From Patients With Psoriasis Vulgaris

Role of m6A RNA methylation in cardiovascular disease (Review)

Contact Info

Product

Resources

About