Increased M2 Isoform of Pyruvate Kinase in Fibroblasts Contributes to the Growth, Aggressiveness, and Osteoclastogenesis of Odontogenic Keratocysts

HIF‐1α signaling pathway is related with glycolysis in odontogenic keratocysts at single‐cell level

“…However, the metabolic profile of OKC remains lacking. A previous study illustrated that aerobic glycolysis is activated in OKC fibroblasts and promotes the growth and aggressiveness of OKCs (Zou et al, 2021). Moreover, 96.4% of OKC tissues have variable HIF-1α expression levels indicating its potential relation with glycolysis (You et al, 2022).…”