Increased live births after day 5 versus day 6 transfers of vitrified-warmed blastocysts

Tubbing, Alice; Shaw-Jackson, Chloë; Ameye, Lieveke; Colin, Jérôme; Rozenberg, Serge; Autin, Candice

doi:10.1007/s10815-017-1097-x

Cited by 40 publications

(23 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The OR remained significant after controlling for age, number of transferred embryos, and treatment protocol (19). The superiority of day 5 over day 6 blastocysts in FET cycles was also reported in several other studies (18,(32)(33)(34).…”

Section: Figuresupporting

confidence: 71%

Blastocyst development rate influences implantation and live birth rates of similarly graded euploid blastocysts

Irani

O’Neill

Palermo

et al. 2018

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

Section: Figuresupporting

confidence: 71%

Blastocyst development rate influences implantation and live birth rates of similarly graded euploid blastocysts

Irani

O’Neill

Palermo

et al. 2018

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…The final inclusion was 13 studies that met the selection criteria for our meta‐analysis. Hence, 23 studies were included in the following meta‐analyses . The main characteristics and assessment for risk of bias of the included studies are presented in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Hence, 23 studies were included in the following meta-analyses. 4,6,7,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] The main characteristics and assessment for risk of bias of the included studies are presented in Table 1.…”

Section: Results Of the Searchesmentioning

confidence: 99%

Pregnancy outcomes after day 5 versus day 6 blastocyst‐stage embryo transfer: A systematic review and meta‐analysis

Wang²,

Sun

et al. 2020

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Aim To compare the pregnancy outcomes after day 5 blastocyst‐stage embryo transfers (BET) versus day 6 BET following vitrified‐warmed cycle and to evaluate whether the number of embryos transferred and the chromosomal status of embryo influence effect estimates. Methods A literature search (PubMed, Embase and MEDLINE) up to January 2019 was conducted to identify studies where women with day 6 BET were compared to women with day 5 BET. Only studies published in English language, on peer‐reviewed journal were considered eligible. The following subgroup analyses were performed: (i) number of embryos transferred and (ii) chromosomal status of embryo. Results From a total of 1956 articles identified, 23 observational studies were included in the meta‐analysis. We observed that day 6 BET were associated with lower implantation rate (risk ratio, RR: 1.17, 95% confidence interval, CI: 1.10–1.24), clinical pregnancy rate (RR: 1.17, 95% CI: 1.10–1.24), ongoing pregnancy rate (RR: 1.15, 95% CI: 1.07–1.24) and live birth rate (RR: 1.22, 95% CI: 1.11–1.33) than day 5 BET following vitrified‐warmed cycle. The subgroup analysis found that the superiority of day 5 BET compared with day 6 BET is influenced by the number of embryos transferred and chromosomal status of embryos. Conclusion Current evidence shows that day 5 BET is superior to day 6 BET following vitrified‐warmed cycle in clinical practice. Due to the overall low quality of available evidence, more larger and well‐conducted studies are needed to compare the pregnancy outcomes between day 5 and day 6 BET before drawing a clear conclusion.

show abstract

“…Some reports showed equivalent outcomes between blastocysts formed and cryopreserved on day 5 (D5 blastocysts) and blastocysts formed and cryopreserved on day 6 (D6 blastocysts) [11][12][13][14]. Meanwhile, there is a growing body of evidence indicating that the CPR, IR, and live birth rate (LBR) with D5 blastocysts are higher than with D6 blastocysts in FET cycles [15][16][17][18][19][20]. Therefore, whether the day of blastocyst formation affects clinical outcomes remains controversial.…”

Section: Introductionmentioning

confidence: 99%

D6 blastocyst transfer on day 6 in frozen-thawed cycles should be avoided: a retrospective cohort study

Qiu

Chen

et al. 2020

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background There is no definitive evidence about the suitable timing to transfer blastocysts formed and cryopreserved on day 6 (D6 blastocysts) in frozen-thawed embryo transfer (FET) cycles. This study aimed to investigate the suitable timing to transfer D6 blastocysts in FET cycles and to identify factors affecting clinical pregnancy rate (CPR) and early miscarriage rate (EMR) in FET cycles with blastocysts. Methods This retrospective cohort study included 1788 FET cycles with blastocysts. There were 518 cycles with D6 blastocysts, and 1270 cycles with blastocysts formed and cryopreserved on day 5 (D5 blastocysts) (D5 group). According to the blastocyst transfer timing, the cycles with D6 blastocysts were divided into cycles with D6 blastocysts transferred on day 5 (D6-on-D5 group, 103 cycles) and cycles with D6 blastocysts transferred on day 6 (D6-on-D6 group, 415 cycles). The chi-square test, independent t-test or Mann-Whitney test, and logistic regression analysis were used for data analysis. Results The CPR and implantation rate (IR) were significantly higher in the D6-on-D5 group than in the D6-on-D6 group (55.3% vs. 37.3%, 44.8% vs. 32.6%, P < 0.01). The CPR and IR were significantly higher in the D5 group than in the D6-on-D5 group (66.0% vs. 55.3%, 62.1% vs. 44.8%, P < 0.05), and the EMR was significantly lower in the D5 group than in the D6-on-D5 group (11.2% vs. 21.1%, P < 0.05). Logistic regression analysis demonstrated that transfer D6 blastocysts on day 5, instead of day 6, could significantly increase the CPR (odds ratio[OR]: 2.031, 95% confidence interval (CI): 1.296–3.182, P = 0.002). FET cycles with D6 blastocysts transferred on day 5 had a higher EMR than those with D5 blastocysts (OR: 2.165, 95% CI: 1.040–4.506, P = 0.039). Hormone replacement therapy (HRT) cycles exhibited a higher EMR than natural cycles (OR: 1.953, 95% CI: 1.254–3.043, P = 0.003), while no difference was observed in the CPR (P > 0.05). Conclusions These results indicate that the suitable timing to transfer D6 blastocysts in FET cycles may be day 5, and D6 blastocyst transfer on day 6 in FET cycles should be avoided. D6 blastocysts transfer and HRT cycles may be associated with a higher EMR.

show abstract

Increased live births after day 5 versus day 6 transfers of vitrified-warmed blastocysts

Cited by 40 publications

References 22 publications

Blastocyst development rate influences implantation and live birth rates of similarly graded euploid blastocysts

Blastocyst development rate influences implantation and live birth rates of similarly graded euploid blastocysts

Pregnancy outcomes after day 5 versus day 6 blastocyst‐stage embryo transfer: A systematic review and meta‐analysis

D6 blastocyst transfer on day 6 in frozen-thawed cycles should be avoided: a retrospective cohort study

Contact Info

Product

Resources

About