2006
DOI: 10.1016/j.jneuroim.2006.04.002
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Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy

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Cited by 17 publications
(16 citation statements)
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“…A subsequent article by the same group demonstrated that B 12 deficiency in the rat, whether induced by dietary deprivation or total gastrectomy, causes a progressive decrease in CSF IL-6 levels, which is reversible with B 12 administration. These results demonstrated that B 12 also directly regulates the CSF levels of IL-6 [50].…”
Section: A New Model: the Role Of Cytokines And Growth Factorsmentioning
confidence: 61%
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“…A subsequent article by the same group demonstrated that B 12 deficiency in the rat, whether induced by dietary deprivation or total gastrectomy, causes a progressive decrease in CSF IL-6 levels, which is reversible with B 12 administration. These results demonstrated that B 12 also directly regulates the CSF levels of IL-6 [50].…”
Section: A New Model: the Role Of Cytokines And Growth Factorsmentioning
confidence: 61%
“…This theory is independent of the coenzyme functions of vitamin B 12 described above, and is instead based on the role of B 12 in the regulation of cytokines and growth factors. The theory is largely the work of Scalabrino and colleagues, who have developed a subacute combined degeneration model in the totally gastrectomized rat [50]. Using this model, they have demonstrated that B 12 deficiency leads to increased spinal cord synthesis and increased CSF levels of two myelinotoxic cytokines, tumor necrosis factor (TNF)-α and soluble (s) CD40:sCD40 ligand dyad, and a myelinotoxic growth factor, nerve growth factor (NGF).…”
Section: A New Model: the Role Of Cytokines And Growth Factorsmentioning
confidence: 99%
“…administration of S-adenosyl-L-methionine (a known inhibitor of TNF-␣ synthesis) to Cbl-D rats significantly decreases CSF sCD40 and sCD40L levels without modifying their Cbl-D status, and simultaneously substantially reduces their SC myelin lesions, and the i.c.v. administration of transforming growth factor ␤ 1 (which greatly reduces TNF-␣ production by astrocytes) has S-adenosyl-L-methionine-like effects on CSF sCD40 and sCD40L levels and the ultrastructure of SC white matter in Cbl-D rats (Veber et al, 2006).…”
Section: Regulation Of the Cns Cytokine And Growth Factor Networkmentioning
confidence: 99%
“…The importance of SAM as neuroprotective agent is emphasized by the findings that: (i) SAM treatment to Cbl-D rats substantially reduced the severity of the SC white matter lesions and significantly decreased the CSF levels of soluble CD40 ligand (a cellsurface protein belonging to the TNF family) [22]; and (ii) SAM treatment of neuroblastoma cells cultured in a vitamin B-deficient medium restores normal gene methylation levels of presenilin-1, previously decreased by vitamin B deficiency [23].…”
Section: Introductionmentioning
confidence: 99%