Increased levels of persistent organic pollutants in serum one year after a great weight loss in humans: Are the levels exceeding health based guideline values?

Jansen, A. A. J.; Polder, Anuschka; Müller, Mette Helen Bjørge; Skjerve, Eystein; Aaseth, Jan; Lyche, Jan Ludvig

doi:10.1016/j.scitotenv.2017.11.241

Cited by 23 publications

(16 citation statements)

References 57 publications

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“…Several POPs are endocrine-disrupting chemicals (EDCs) with potential adverse effects (Darnerud, 2003;Birnbaum, 2013;Gore et al, 2015). We have in previous studies shown significant increases in POPs and changes in the hormones adiponectin, leptin and ghrelin after bariatric surgery (Jansen et al, 2018;Farup et al, 2022). However, associations between POPs and the hormones, which was the aim of this study, have as far as we are aware of, not been studied.…”

Section: Introductionmentioning

confidence: 85%

“…The study used data from the prospective cohort study "Morbid Obesity -Bio-Psycho-Social impacts" (MO-BiPS) (Farup, 2020). The subject characteristics and the POPs and hormone analyses have been published in different contexts in two papers, one studied the levels of POPs after bariatric surgery, and the other APOE polymorphism and endocrine functions (Jansen et al, 2018;Farup et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

“…POPs are lipophilic, highly resistant to metabolic degradation, accumulate in adipose tissue and fat-rich organs and have long half-lives (Birnbaum, 1985;Wania and Mackay, 1996;AMAP, 1997). Following bariatric surgery, they are released from the adipose tissue and redistributed, resulting in increased blood concentrations (Kim et al, 2011;Dirtu et al, 2013;Rantakokko et al, 2015;Jansen et al, 2018). Several POPs are endocrine-disrupting chemicals (EDCs) with potential adverse effects (Darnerud, 2003;Birnbaum, 2013;Gore et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?

et al. 2023

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Section: Introductionmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?

et al. 2023

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“…An example would be patients who experienced significant weight loss in a short period after bariatric surgery and consequently increased these substances in the blood (Jansen et al, 2018). However, it is essential to mention that pesticide metabolites with a more hydrophilic could be more easily detected in the blood (E. Dirinck et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Exposure to pesticides and overweight - A systematic review

Skonieski

Silva

Fagundes

et al. 2022

RSD

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This study results from a systematic review to investigate the possible relationship between pesticide exposure and the induction of body overweight in adult individuals. We used the PICO strategy (Population, Interventions/exposure, Comparisons, Outcomes) and the PUBMED, SCIENCE DIRECT and SCOPUS databases to perform the research. In this review, were included 15 studies, classified as research articles. The data presented demonstrated that 86.66% (13/15) of the studies positively correlated overweight and pesticide exposure. Additionally, we observed exposure to pesticides regarding deregulation mechanism of glucose (increase levels of glucose, insulin and homeostasis model assessment insulin resistance index (HOMA-IR)) and deregulation lipid homeostasis (increase levels of triglycerides and decreased levels of high-density lipoprotein (HDL)). These findings proposed an increase in the risk of cardiac diseases and diabetes. As well, these results show that exposure to pesticides can also increase the risk of overweight development. However, further studies are needed to determine the possible mechanism.

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“…Jansen et al. (2018) analysed serum samples that were collected between 2012 and 2014 from 63 patients before and 1 year after bariatric surgery for organochlorine pesticides, PCBs and certain BFRs by GC/low resolution MS (LRMS). The LOD for Total HBCDDs was 0.033 ng/g lipid.…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of hexabromocyclododecanes (HBCDDs) in food

Schrenk

Bignami

Bodin³

et al. 2021

EFS2

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The European Commission asked EFSA to update its 2011 risk assessment on hexabromocyclododecanes ( HBCDD s) in food. HBCDD s, predominantly mixtures of the stereoisomers α‐, β‐ and γ‐ HBCDD , were widely used additive flame retardants. Concern has been raised because of the occurrence of HBCDD s in the environment, food and in humans. Main targets for toxicity are neurodevelopment, the liver, thyroid hormone homeostasis and the reproductive and immune systems. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour in mice can be considered the critical effects. Based on effects on spontaneous behaviour in mice, the Panel identified a lowest observed adverse effect level ( LOAEL ) of 0.9 mg/kg body weight (bw) as the Reference Point, corresponding to a body burden of 0.75 mg/kg bw. The chronic intake that would lead to the same body burden in humans was calculated to be 2.35 μg/kg bw per day. The derivation of a health‐based guidance value ( HBGV ) was not considered appropriate. Instead, the margin of exposure ( MOE ) approach was applied to assess possible health concerns. Over 6,000 analytical results for HBCDD s in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary LB exposure to HBCDD s were fish meat, eggs, livestock meat and poultry. The CONTAM Panel concluded that the resulting MOE values support the conclusion that current dietary exposure to HBCDD s across European countries does not raise a health concern. An exception is breastfed infants with high milk consumption, for which the lowest MOE values may raise a health concern.

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Increased levels of persistent organic pollutants in serum one year after a great weight loss in humans: Are the levels exceeding health based guideline values?

Cited by 23 publications

References 57 publications

Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?

Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?

Exposure to pesticides and overweight - A systematic review

Update of the risk assessment of hexabromocyclododecanes (HBCDDs) in food

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