Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?

Jansen, A. A. J.; Aaseth, Jan; Lyche, Jan L.; Berg, Jens Petter; Müller, Mette Helen Bjørge; Lydersen, Stian; Farup, Per G.

doi:10.1016/j.chemosphere.2022.137461

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…Significant weight loss leads to an increase in plasma levels of adiponectin, a signaling peptide that regulates the metabolism of lipids and glucose, and a decrease in levels of leptin, a hormone involved in regulation of energy balance and appetite [40,41]. The rapid mobilization of lipophilic POPs from the adipose tissue into the bloodstream that occurs after bariatric surgery can lead to the dysregulation of these hormones [41][42][43]. However, results have been inconsistent and at times contradictory; therefore, studies investigating the potential mechanisms leading to these associations are still needed.…”

Section: Discussionmentioning

confidence: 99%

Exposure to 4,4′‐DDE in visceral adipose tissue and weight loss in adolescents from the Teen‐LABS cohort

Rubbo,

Li,

Tachachartvanich

et al. 2024

Obesity

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ObjectiveDichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes.MethodsWe included 63 participants from the Teen‐Longitudinal Assessment of Bariatric Surgery (Teen‐LABS) cohort. We assessed 4,4′‐DDE in visceral adipose tissue at surgery and BMI and waist circumference at surgery and 0.5, 1, 3, and 5 years after. We conducted longitudinal analysis to estimate the interaction on weight loss between DDE and time since surgery. In vitro analysis quantified adipogenic differentiation in commercial human preadipocytes exposed to 4,4′‐DDE via fluorescent staining and imaging.ResultsA dose–response relationship was observed, with the low‐exposure group having a greater reduction in BMI during the first year compared to higher‐exposure groups and showing smaller regains compared to higher‐exposure groups after the first year. In vitro analysis of preadipocytes treated with 4,4′‐DDE during adipogenic differentiation for 12 days showed a concentration‐dependent increase in lipid accumulation.ConclusionsDDE could contribute to weight trajectory among adolescents undergoing bariatric surgery, potentially mediated via promoted adipogenesis in preadipocytes.

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Section: Discussionmentioning

confidence: 99%

Exposure to 4,4′‐DDE in visceral adipose tissue and weight loss in adolescents from the Teen‐LABS cohort

Rubbo,

Li,

Tachachartvanich

et al. 2024

Obesity

View full text Add to dashboard Cite

show abstract

“…This makes each person a unique case to be treated. Furthermore, the increase in POP concentrations following bariatric surgery has been shown to be potentially associated with hormonal changes in humans [159]. Finally, the ability of POPs to spread to other organs (e.g., like the brain) via the bloodstream should be considered [160].…”

Section: Bariatric Surgery Is Associated With An Important Increase I...mentioning

confidence: 99%

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Serrano,

Le Garf,

Martin

et al. 2024

IJMS

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Obesity affects nearly 660 million adults worldwide and is known for its many comorbidities. Although the phenomenon of obesity is not fully understood, science regularly reveals new determinants of this pathology. Among them, persistent organic pollutants (POPs) have been recently highlighted. Mainly lipophilic, POPs are normally stored in adipose tissue and can lead to adverse metabolic effects when released into the bloodstream. The main objective of this narrative review is to discuss the different pathways by which physical activity may counteract POPs’ adverse effects. The research that we carried out seems to indicate that physical activity could positively influence several pathways negatively influenced by POPs, such as insulin resistance, inflammation, lipid accumulation, adipogenesis, and gut microbiota dysbiosis, that are associated with the development of obesity. This review also indicates how, through the controlled mobilization of POPs, physical activity could be a valuable approach to reduce the concentration of POPs in the bloodstream. These findings suggest that physical activity should be used to counteract the adverse effects of POPs. However, future studies should accurately assess its impact in specific situations such as bariatric surgery, where weight loss promotes POPs’ blood release.

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“…This makes each person a unique case to be treated. Furthermore, the increase of POPs concentration following bariatric surgery has been shown to be potentially associated with hormonal changes in humans 12 [156]. Finally, the ability of POPs to spread to other organs (e.g., like the brain) via the bloodstream should be considered [157].…”

Section: Bariatric Surgery Is Associated With An Important Increase O...mentioning

confidence: 99%

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Serrano,

Le Garf,

Martin

et al. 2023

Preprint

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Obesity affects nearly 660 million adults worldwide and is known for its many comorbidities. Although the phenomenon of obesity is not fully understood, science regularly reveals new determinants of this pathology. Among them, the persistent organic pollutants (POPs) have been recently highlighted. Mainly lipophilic, POPs are normally stored in adipose tissue and can lead to adverse metabolic effects when released into the bloodstream. The main objective of this narrative review is to discuss the different pathways by which physical activity may counteract POPs adverse effects. The research that we carried out seems to indicate that physical activity could positively influence several pathways negatively influenced by POPs, such as insulin resistance, inflammation, lipid accumulation, adipogenesis and gut microbiota dysbiosis that are associated with the development of obesity. This review also indicates how, through the controlled mobilization of POPs, physical activity could be a valuable approach to reduce the concentration of POPs in the bloodstream. These findings suggest that physical activity should be used to counteract the adverse effects of POPs. However, future studies should accurately assess its impact in specific situations such as bariatric surgery where weight loss promotes POPs blood release.

show abstract

Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?

Cited by 3 publications

References 49 publications

Exposure to 4,4′‐DDE in visceral adipose tissue and weight loss in adolescents from the Teen‐LABS cohort

Exposure to 4,4′‐DDE in visceral adipose tissue and weight loss in adolescents from the Teen‐LABS cohort

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

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