Increased levels of myeloid-derived suppressor cells in esophageal cancer patients is associated with the complication of sepsis

Xu, Jingjing; Peng, Yahui; Yang, Meimei; Guo, Ning; Liu, Haitao; Gao, Hong; Niu, Fangfang; Wang, Changsong; Yu, Kaijiang

doi:10.1016/j.biopha.2020.109864

Cited by 12 publications

(5 citation statements)

References 31 publications

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“…Two subsets of MDSCs, the monocytic MDSCs (Mo-MDSCs, CD11b + Ly6C + Ly6G -) and the polymorphonuclear MDSCs (PMN-MDSCs, CD11b + Ly6C int/lo Ly6G + ) have been identified in patients and murine models of disease. These include cancer, systemic inflammation and sepsis, autoimmune diseases as well as bacterial, viral and parasitic infections (18)(19)(20)(21)(22)(23)(24)(25)(26). Mo-MDSCs and PMN-MDSCs are reported to suppress T and B cell responses through receptors, cytokines, or soluble factors as reviewed (20,27).…”

Section: Introductionmentioning

confidence: 99%

Infection-Derived Monocytic MDSCs Require TGF-β to Suppress Filarial-Specific IFN-γ But Not IL-13 Release by Filarial-Specific CD4+ T Cells In Vitro

Tamadaho¹,

Ritter²,

Wiszniewsky³

et al. 2022

Front. Trop. Dis

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Lymphatic filariasis (LF) remains a major health problem with severe economic repercussions in endemic communities of Sub-saharan Africa, South-East Asia and South America. The rodent-specific nematode Litomosoides sigmodontis (Ls) is used to study the immunomodulatory potential of filariae and research has elucidated pathways involving regulatory T cells (Tregs), IL-10 producing cells and alternatively activated macrophages (AAMs) and that CD4+ T cells play a paramount role during infection. Myeloid-derived suppressor cells (MDSCs) have been identified and characterised in man in cancer and other pathologies. The hallmark of MDSC populations is the suppression of T and B cell responses using various mechanisms, which are mostly specific to the pathology or setting. However, until now, it remains unclear whether they play a role in filarial-specific responses. We report here that monocytic MDSCs (Mo-MDSCs, CD11b+Ly6C+Ly6G-) and polymorphonuclear MDSCs (PMN-MDSCs, CD11b+Ly6Cint/loLy6G+) expanded in the thoracic cavity (TC, the site of infection) and correlated positively with filarial life-stages in Ls-infected BALB/c mice. In vitro, only infection-derived Mo-MDSCs showed a suppressive nature by preventing IL-13 and IFN-γ secretion from filarial-specific CD4+ T cells upon co-culture with soluble worm extract. This suppression was not mediated by IL-10, IL-6 or TNF-α, and did not require cell-contact, nitric oxide (NO), IL-4/IL-5 signalling pathways or CCR2. Interestingly, neutralizing TGF-β significantly rescued IFN-γ but not IL-13 production by filarial-specific CD4+ T cells. In comparison to naive cells, PCR array data showed an overall down-regulation of inflammatory pathways in both infection-derived Mo-MDSCs and PMN-MDSCs. In conclusion, these primary data sets show activity and expansion of MDSCs during Ls infection adding this regulatory cell type to the complex milieu of host responses during chronic helminth infections.

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Section: Introductionmentioning

confidence: 99%

Infection-Derived Monocytic MDSCs Require TGF-β to Suppress Filarial-Specific IFN-γ But Not IL-13 Release by Filarial-Specific CD4+ T Cells In Vitro

Tamadaho¹,

Ritter²,

Wiszniewsky³

et al. 2022

Front. Trop. Dis

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“…EC has become a common malignancy of the digestive tract that affects about 300 000 people worldwide each year (Triantafyllou et al, 2020). Though surgical treatment is the most common treatment for early EC (Yamamoto et al, 2020), in patients with advanced EC high heterogeneity and metastasis are observed, targeted therapies have thus emerged as a new therapeutic direction (Xu et al, 2020). In order to improve the survival rate of patients with EC, it is still urgent to develop new EC therapeutic targets.…”

Section: Discussionmentioning

confidence: 99%

RAB11A mediates the proliferation and motility of esophageal cancer cells via WNT signaling pathway

2020

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Esophageal cancer (EC) recently has become a common malignancy of digestive system worldwide. RAB11A is a critical member of the small GTPases superfamily and was reported to affect a variety of cellular functions. However, its potential effects on EC progression and the specific regulatory mechanisms are still unclear. In this study, RAB11A was upregulated in human EC tissues and cells and predicted poor diagnosis. RAB11A expression was correlated with clinical-pathological features including pTNM stage (P=0.001*) and recurrence (P=0.000**) in patients with EC. Furthermore, RAB11A knockdown decreased the proliferation, migration, and invasion of EC cells via WNT pathway in vitro. Subsequently, the in vivo experiments confirmed that RAB11A contributed to EC tumor growth via WNT pathway. Therefore, these results provided evidence showing that RAB11A could promote the progression of EC via WNT pathway and might serve as a promising therapeutic target for EC treatment.

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“…In addition to the factors identified in this study, international investigations highlight other clinical and microbiological aspects that may increase the chance of sepsis and septic shock in cancer patients, such as chemotherapy-induced neutropenia (44)(45)(46)(47) ; the presence of biological markers -myeloid-derived granulocytic suppressor cells (G-MDSCs) after esophageal surgery (46) ; solid tumors often associated with infections of the gastrointestinal tract (47) ; and bacteria such as Staphylococcus spp., E. coli, K. pneumoniae, E. faecalis and S. aureus (48) .…”

Section: Prevalence and Factors Associated With Sepsis And Septic Shock In Oncological Patients In Intensive Therapymentioning

confidence: 95%

Prevalence and factors associated with sepsis and septic shock in oncological patients in intensive therapy

2022

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Objectives: to analyze factors associated with sepsis and septic shock in cancer patients in the Intensive Care Unit. Methods: cross-sectional, retrospective study with a quantitative approach, with a sample of 239 patients in an oncology hospital. Secondary data from medical records were used. The outcome variable was “presence of sepsis and/or septic shock”; and exposures: sex, length of stay, origin, use of invasive procedures and primary tumor site. Descriptive, bivariate analyzes and multiple logistic regression models were performed. Results: the prevalence of sepsis was 95% CI: 14.7-24.7 and septic shock of 95% CI: 37.7-50.3. In the multiple analysis, sepsis and/or septic shock were associated with hospital stay longer than seven days, being from the Emergency Department, presence of invasive procedures and hematological site. Conclusions: sepsis and/or septic shock in cancer patients were associated with clinical characteristics and health care factors.

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Increased levels of myeloid-derived suppressor cells in esophageal cancer patients is associated with the complication of sepsis

Cited by 12 publications

References 31 publications

Infection-Derived Monocytic MDSCs Require TGF-β to Suppress Filarial-Specific IFN-γ But Not IL-13 Release by Filarial-Specific CD4+ T Cells In Vitro

Infection-Derived Monocytic MDSCs Require TGF-β to Suppress Filarial-Specific IFN-γ But Not IL-13 Release by Filarial-Specific CD4+ T Cells In Vitro

RAB11A mediates the proliferation and motility of esophageal cancer cells via WNT signaling pathway

Prevalence and factors associated with sepsis and septic shock in oncological patients in intensive therapy

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