Increased levels of MMP-3, MMP-9 and MPO represent predictors of in-stent restenosis, while increased levels of ADMA, LCAT, ApoE and ApoD predict bare metal stent patency

Abstract

Aims. We sought to identify biochemical predictors that indicate susceptibility to in-stent restenosis (ISR) after coronary artery bare-metal stenting. Methods. A total of 111 consecutive patients with post-percutaneous coronary intervention (PCI) in-stent restenosis of a target lesion within 12 months were matched for age, sex, vessel diameter, and diabetes with 111 controls without post-PCI ISR. Plasma or serum levels of biochemical markers were measured: matrix metalloproteinases (MMP) 2, 3, 9; myeloperoxidase (MPO); asymmetric dimethylarginine (ADMA); lipoprotein (a) (Lp[a]); apolipoproteins E and D (ApoE and D); and lecitin-cholesterol acyltransferase (LCAT). Multivariable logistic regression association tests were performed. Results. Increased plasma MMP-3 (OR: 1.013; 95% CI: 1.004-1.023; P = 0.005), MMP-9 (OR: 1.014; 95% CI: 1.008-1.020; P < 0.0001) or MPO (OR: 1,003; 95% CI: 1.001-1.005; P = 0.002) was significantly associated with increased risk of ISR. Increased levels of ADMA (OR: 0.212; 95% CI: 0.054-0.827; P = 0.026), ApoE (OR: 0.924; 95% CI: 0.899-0.951; P < 0.0001), ApoD (OR: 0.919; 95% CI: 0.880-0.959; P = 0.0001), or LCAT (OR: 0.927; 95% CI: 0.902-0.952; P < 0.0001) was associated with risk reduction. No correlation was found between plasma MMP-2 or Lp (a) and ISR risk. Conclusions. Increased levels of MMP-3, MMP-9, and MPO represent predictors of ISR after bare-metal stent implantation. In contrast, increased ADMA, LCAT, and Apo E and D indicate a decreased in-stent restenosis occurrence.

Adventitial SCA-1 + Progenitor Cell Gene Sequencing Reveals the Mechanisms of Cell Migration in Response to Hyperlipidemia

“…Thus, miRNA expression levels may have a strong influence in controlling the disease. Our experiments show that miR-29b elicits a response to the migratory potential of lipid-loaded AdvSCA-1 + , possibly via Sirt1 and MMP-9, with the latter documented to play a role in atherosclerosis ( Chen et al., 2008 , Gough et al., 2006 , Pleva et al., 2015 ), while the former is a molecule now shown to be involved in AdvSCA-1 + progenitors. Of note, it has been reported that human MiR-29b has been implicated in ECM remodeling including collagen regulation ( Kriegel et al., 2012 ), while its dysregulation in murine cardiac fibroblasts upon post-myocardial infraction led to decreased collagen formation and fibrosis ( van Rooij et al., 2008 ).…”

Associations of myeloperoxidase, interleukin-17A and heparin-binding EGF-like growth factor levels with in-stent restenosis after percutaneous coronary intervention: a single-centre case–control study in China

“…[23][24][25] Therefore, as a biomarker of oxidative stress, MPO could be measured to help assess the effectiveness of revascularisation after PCI, and thus predicting the development of ISR. This is supported by Pleva et al 26 Claessen et al 27 showed that high MPO levels at 30 days were associated with ISR. Open access IL-17A plays an important role in various inflammatory diseases by participating in the regulation of chronic inflammation, the formation of atherosclerosis, thrombi and plaque instability.…”

Matrix Metalloproteinases MMP-3 and MMP-9 as Predictors of In-Stent Restenosis

“…Nevertheless, the ISR group showed particularly lower total cholesterol (p = 0.016) and Low-density lipoprotein (LDL) (p = 0.001), and notably higher NT-pro-BNP (p = 0.010), in comparison to the treatment group. Table 1 shows the summary of plasma levels of matrix metalloproteinases in all groups [13].…”

“…Table 4. Logistic regression analysis (separately for each parameter with adjustment for diabetes mellitus (DM)) [13]. Based on receiver operating characteristic (ROC) analysis, the plasma abundance of MMP-9 may be considered the most suitable parameter for use in ISR risk prediction ( Table 5 and Figure 1).…”