Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome: Relationship with oxidative stress

Helal, Olfa; Defoort, Catherine; Robert, Stéphane; Marı́n, Carmen; Lesavre, Nathalie; López‐Miranda, José; Risérus, Ulf; Basu, Samar; Lovegrove, Julie A.; McMonagle, Jolene; Roche, Helen M.; Dignat-George, Françoise; Lairon, Denis

doi:10.1016/j.numecd.2010.01.004

Cited by 101 publications

(72 citation statements)

References 31 publications

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“…Similar findings on microparticle phenotyping have been described by Helal et al [70]. They reported in a bicentric cohort of MetS patients and healthy controls that patients had significantly higher circulating levels of platelet-, erythrocyte-and endothelial-derived microparticles in addition to pro-coagulant microparticles than MetS-free controls.…”

Section: Metabolic Syndrome (Mets)supporting

confidence: 87%

“…In that study, multivariate analysis showed that waist circumference positively influenced the level of both platelet and endothelial microparticles. BMI positively correlated with pro-coagulant and endothelial microparticles and blood pressure positively influenced the level of endothelial microparticles [70]. Previous studies have also addressed microparticles in patients with MetS.…”

Section: Metabolic Syndrome (Mets)mentioning

confidence: 99%

See 1 more Smart Citation

Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components

Agouni¹,

Andriantsitohaina²,

Martinez

2014

CVP

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Section: Metabolic Syndrome (Mets)supporting

confidence: 87%

Section: Metabolic Syndrome (Mets)mentioning

confidence: 99%

Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components

Agouni¹,

Andriantsitohaina²,

Martinez

2014

CVP

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“…This is the first study that assessed plasma PMPs in PCOS. Previous reports showed that cardiovascular risk factors that are frequent in women with PCOS, including obesity, metabolic syndrome, and type 2 diabetes mellitus, are also associated with elevated plasma PMPs (17,(25)(26)(27). A correlation among plasma PMPs and BMI, W, and serum glucose levels has also been reported (25,26).…”

Section: Discussionmentioning

confidence: 93%

“…Previous reports showed that cardiovascular risk factors that are frequent in women with PCOS, including obesity, metabolic syndrome, and type 2 diabetes mellitus, are also associated with elevated plasma PMPs (17,(25)(26)(27). A correlation among plasma PMPs and BMI, W, and serum glucose levels has also been reported (25,26). However, in this study, women with PCOS did not differ with controls in markers of adiposity (BMI, WC, and WC/H) or in indices of insulin resistance and impaired glucose metabolism (serum glucose and insulin levels, glucose/insulin ratio, HOMA-IR, QUICKI, and area under the OGTT curve).…”

Section: Discussionmentioning

confidence: 99%

Circulating platelet-derived microparticles are elevated in women with polycystic ovary syndrome diagnosed with the 1990 criteria and correlate with serum testosterone levels

Koiou

Τζιόμαλος

Katsikis

et al. 2011

European Journal of Endocrinology

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Objective: Women with polycystic ovary syndrome (PCOS) appear to have higher cardiovascular risk than healthy population. Patients diagnosed with PCOS according to the 1990 criteria have a more adverse metabolic profile than those diagnosed with the 2003 criteria. Platelet-derived microparticles (PMPs) appear to contribute to atherosclerosis but have not been assessed in PCOS. The aim of this study was to determine plasma PMPs in PCOS patients. Design: A cross-sectional study. Methods:We assessed plasma PMPs in 76 normal weight women with PCOS (39 belonging to the phenotypes 1 and 2 (group I) and 37 belonging to the phenotypes 3 and 4 (group II)) and 21 healthy normal weight women. Results: Markers of obesity and insulin resistance did not differ between women with PCOS and controls. Serum testosterone levels and the free androgen index (FAI) were higher in group I than in group II and controls (P!0.001 for all comparisons) but did not differ between the latter two groups. Plasma PMPs were higher in group I than in controls (PZ0.018) but did not differ between group II and controls or between groups I and II. In the total study population (nZ97), plasma PMPs correlated with serum testosterone levels (rZ0.207, PZ0.042) and the FAI (rZ0.207, PZ0.042). Conclusions: Plasma PMPs are elevated in women with phenotypes 1 and 2 of PCOS compared with healthy controls, but not in women with phenotypes 3 and 4. Hyperandrogenemia, which is more pronounced in phenotypes 1 and 2, appears to be implicated in the increase in plasma PMPs.

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“…Previous studies have suggested that insulin resistance, a common feature in obesity or metabolic syndrome, could be directly implicated in platelet stimulation. 23 The possible mechanisms involved in platelet stimulation in obesity are related to: (i) the reduced sensitivity to insulin and other substances acting through intracellular cyclic nucleotides, such as nitrates and prostacyclin; (ii) the rise of cytosolic (Ca 2 þ ); and (iii) the increased oxidative stress, which elicits isoprostane production from arachidonic acid. 24 The administration of insulin inhibits platelet interaction with collagen under conditions mimicking thrombus formation and reduces healthy platelet aggregation in response to several platelets agonists whereas insulin was found to be inefficient in obese, insulin resistant patients.…”

Section: Consequences Of Weight Reduction On Platelet Activationmentioning

confidence: 99%

Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles

et al. 2011

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Background: In obesity, metabolic stress and inflammation in injured tissues could favour enhanced shedding of procoagulant microparticles (MPs). At sites of endothelium injury, the swift recruitment of procoagulant leukocyte-derived MPs enables the initiation of blood coagulation and thrombus growth. Objectives: In obese females, we sought to evaluate the impact of a very low-calorie diet (VLCD) on procoagulant MP levels, fibrinolytic status, inflammation and endothelium damage. Methods: Circulating biomarkers of vascular damage, fibrinolytic status, platelet activation and inflammation were measured before, 30 and 90 days after starting a short-term VLCD. MPs were measured by flow cytometry and capture assays. Their procoagulant potential was quantified using functional prothrombinase assays and their cellular origin were determined using flow cytometry (endothelium, platelet, leukocyte, lymphocyte and erythrocyte-derived MP) or capture assays. Results: A total of 24 obese females (39 ± 10 years) with a mean body mass index of 35 ± 4 kg m À2 were prospectively enroled. Procoagulant leukocyte-derived MPs were associated with the waist circumference at baseline (r ¼ 0.534; P ¼ 0.010) and at 90 days follow-up (r ¼ 0.487; P ¼ 0.021). At 90 days, weight reduction (À9.8%) was associated with a lowering of blood pressure, improvement of metabolic parameters and a significant reduction of plasminogen activator inhibitor-1 (PAI-1) (À38%), procoagulant platelet-derived MPs (À43%), leukocyte-derived MPs (À28%) and leptin (À32%) levels. Conclusion: In obese females, a short-term VLCD results in an overall improvement of the haemostatic balance characterized by the reduction of PAI-levels, diminished release of platelet and leukocyte-derived MPs and a reduction in leptin levels, an adipocyte-derived cytokine.

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Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome: Relationship with oxidative stress

Cited by 101 publications

References 31 publications

Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components

Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components

Circulating platelet-derived microparticles are elevated in women with polycystic ovary syndrome diagnosed with the 1990 criteria and correlate with serum testosterone levels

Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles

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