Increased leukotriene B4 production, complement C3 conversion and acid hydrolase enzyme concentrations in different leucocyte sub-populations of dogs with atopic dermatitis

Breathnach, Rory; Donahy, C.; Jones, B. R.; Bloomfield, F. J.

doi:10.1016/j.tvjl.2004.09.012

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…114 A study of dogs with AD showed that there was a significant increase in the median level of LTB 4 production by PMNs compared with that in control animals. 115 A similar study revealed a significant increase in 5-LO and FLAP expression in both non-lesional and lesional skin compared with that in healthy skin. 116 LTB 4 is a potent mediator of itching.…”

Section: Ltb 4 and Atopic Dermatitismentioning

confidence: 68%

The role of leukotrienes in allergic diseases

Liu

Yokomizo

2015

Allergology International

133

106

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Leukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4, are implicated in a wide variety of inflammatory disorders. These lipid mediators are generated from arachidonic acid via multistep enzymatic reactions through which arachidonic acid is liberated from membrane phospholipids through the action of phospholipase A2. LTB4 and CysLTs exert their biological effects by binding to cognate receptors, which belong to the G protein-coupled receptor superfamily. LTB4 is widely considered to be a potent chemoattractant for most subsets of leukocytes, whereas CysLTs are potent bronchoconstrictors that have effects on airway remodeling. LTs play a central role in the pathogenesis of asthma and many other inflammatory diseases. This review will provide an update on the synthesis, biological function, and relevance of LTs to the pathobiology of allergic diseases, and examine the current and future therapeutic prospects of LT modifiers.

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Section: Ltb 4 and Atopic Dermatitismentioning

confidence: 68%

The role of leukotrienes in allergic diseases

Liu

Yokomizo

2015

Allergology International

133

106

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“…However, less is known about the role of complement in the exacerbation of AD. In one study, median conversion of C3 to active C3b was increased in dogs with AD relative to healthy dogs . Complement 3b can act as an opsonin and induce formation of the complement membrane attack complex.…”

Section: Noncellular Innate Immune Factors In Atopic Dermatitismentioning

confidence: 98%

Review: Innate immunity, lipid metabolism and nutrition in canine atopic dermatitis

Pucheu‐Haston

Santoro

Bizikova

et al. 2015

Veterinary Dermatology

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“…Accordingly, there is a great number of reports in the literature on C activation and its consequences in various animals, Brought to you by | University of Michigan Authenticated Download Date | 6/16/15 10:59 PM including rats (9,(29)(30)(31)(32)(33), mice (33), dogs (34)(35)(36)(37), rabbits (38,39) nonhuman primates (40)(41)(42)(43)(44)(45)(46)(47)(48)(49) and pigs (50)(51)(52)(53)(54)(55). Among these experimental systems, it is the pigs' response to C activator liposomes that best mimics the human infusion reactions to liposomes in terms of kinetics and spectrum of symptoms and the conditions of reaction induction (Table 1).…”

Section: Non-standard Immunotoxicity Tests Of Carpa In Different Animalsmentioning

confidence: 99%

Lessons learned from the porcine CARPA model: constant and variable responses to different nanomedicines and administration protocols

Urbanics

Bedőcs

Szebeni

2015

European Journal of Nanomedicine

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Pigs provide a sensitive and quantitative animal model of complement (C) activation-related pseudoallergy (CARPA) caused by liposomes and a wide range of nanoparticulate drugs or drug nanocarriers (nanomedicines). The tetrad of symptoms (hemodynamic, hematological, laboratory and skin changes) that arise within minutes after i.v. injection of reactogenic nanomedicines (RNMs) are highly reproducible among different pigs but the presence, direction and relative severity of symptoms are very different with different RNMs and their administration schedule. Bolus administration of RNMs usually trigger pulmonary hypertension with or without various degrees of systemic hyper-or hypotension, tachy-or bradycardia, arrhythmia, blood cell and inflammatory mediator changes and skin rash. These reactions can be rapid or protracted, and fully tachyphylactic, semi-tachyphylactic or non-tachyphylactic. Slow infusion usually diminishes the reactions and/or entail delayed, protracted and less severe hemodynamic and other changes. The goal of this review is to present some technical details of the porcine CARPA model, point out its constant and variable parameters, show examples of different reactions, highlight the unique features and capabilities of the model and evaluate its utility in preclinical safety assessment. The information obtained in this model enables the understanding of the complex pathomechanism of CARPA involving simultaneous anaphylatoxin and inflammatory mediator actions at multiple sites in different organs.

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Increased leukotriene B4 production, complement C3 conversion and acid hydrolase enzyme concentrations in different leucocyte sub-populations of dogs with atopic dermatitis

Cited by 5 publications

References 28 publications

The role of leukotrienes in allergic diseases

The role of leukotrienes in allergic diseases

Review: Innate immunity, lipid metabolism and nutrition in canine atopic dermatitis

Lessons learned from the porcine CARPA model: constant and variable responses to different nanomedicines and administration protocols

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