Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals

Dielen, Fmh van; Veer, Cornelis van ’t; Schols, A.M.W.J.; Soeters, Peter B.; Buurman, Wim A.; Greve, Jan-Willem M.

doi:10.1038/sj.ijo.0801825

Cited by 197 publications

(133 citation statements)

References 61 publications

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“…However, in our study, CRP was significantly correlated with leptin concentrations. This association, which was not observed after adjustment for BF in multivariate regression analysis, is in agreement with previous studies [13,41,43] and suggests that, in addition to leptin, another factor altered in obesity may be involved in the obesityinduced increase in CRP.…”

Section: Discussionsupporting

confidence: 92%

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Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Gómez-Ambrosi

Salvador

Páramo

et al. 2002

Clinical Biochemistry

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Objectives: Recent epidemiologic studies have shown that obesity is associated with elevated blood concentrations of prothromboticproinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), von Willebrand factor (vWF), and homocysteine. We have assessed whether these markers are associated with percentage of body fat (BF), insulin sensitivity as well as with leptin concentrations. Design and methods: Twenty-five men aged 49.6 Ϯ 12.7 yr (mean Ϯ SD) underwent whole-body air displacement plethysmography (Bod-Pod ® ) for estimating BF. Blood analyses for leptin and several other metabolic and cardiovascular markers were carried out. Results: Obese subjects had higher levels as compared to controls of BF (37.5 Ϯ 5.1 vs. 26.0 Ϯ 6.6, p Ͻ 0. Conclusions: Increased BF and impaired insulin sensitivity are associated with increased concentrations of cardiovascular risk factors. Leptin seems to be involved in this elevation and emerges as a predictor of circulating fibrinogen concentrations.

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Section: Discussionsupporting

confidence: 92%

“…Several studies have shown that CRP is elevated in human obesity [36,37] and that it is correlated with indicators of adiposity [37][38][39][40][41]. These discrepancies may be explained taking into account several methodological aspects of the present study.…”

Section: Discussionmentioning

confidence: 77%

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Gómez-Ambrosi

Salvador

Páramo

et al. 2002

Clinical Biochemistry

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“…Obesity is associated with increased circulating levels of inflammatory markers such as acute-phase proteins and cytokines [1][2][3][4][5]. Increasing evidence suggests that cytokines released from adipose tissue contribute to the development of complications related to obesity, including metabolic [6,7] and cardiovascular diseases [8,9].…”

Section: Introductionmentioning

confidence: 99%

Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition

et al. 2005

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Aims/hypothesis: The acute-phase proteins, serum amyloid As (SAA), are precursors of amyloid A, involved in the pathogenesis of AA amyloidosis. This work started with the characterisation of systemic AA amyloidosis concurrent with SAA overexpression in the subcutaneous white adipose tissue (sWAT) of an obese patient with a leptin receptor deficiency. In the present study a series of histopathological, cellular and gene expression studies was performed to assess the importance of SAA in common obesity and its possible production by mature adipocytes. Materials and methods: Gene expression profiling was performed in the sWAT of two extremely obese patients with a leptin receptor deficiency. Levels of the mRNAs of the different SAA isoforms were quantified in sWAT cellular fractions from lean subjects and from obese subjects before and after a very-low-calorie diet. These values were subsequently compared with serum levels of SAA in these individuals. In addition, histopathological analyses of sWAT were performed in lean and obese subjects. Results: In sWAT, the expression of SAA is more than 20-fold higher in mature adipocytes than in the cells of the stroma vascular fraction (p<0.01). Levels of SAA mRNA expression and circulating levels of the protein are sixfold (p<0.001) and 3.5-fold (p<0.01) higher in obese subjects than in lean subjects, respectively. In lean subjects, 5% of adipocytes are immunoreactive for SAA, whereas the corresponding value is greater than 20% in obese subjects. Caloric restriction results in decreases of 45-75% in levels of the transcripts for the SAA isoforms and in circulating levels of the protein. Conclusions/interpretation: The results of the present study indicate that SAA is expressed by sWAT, and its production at this site is regulated by nutritional status. If amyloidosis is seen in the context of obesity, it is possible that production of SAA by adipocytes could be a contributory factor.

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“…Our results are in line with others showing no association between leptin and the acute phase proteins including orosomucoid and CRP after correction for BMI and sex. 47 To our knowledge, this study is also the first to examine the association between components of energy expenditure and subclinical chronic inflammation in a disease-free population. Positive associations between increased REE and other inflammatory markers, such as CRP, IL-6 and TNFa, have been reported in chronically sick patients.…”

Section: Discussionmentioning

confidence: 99%

“…43,44 Energy expenditure may be associated with leptin, 45,46 which is associated with inflammatory markers. 47,48 Considering that we investigated the possible effect of leptin on the relationship between energy expenditure and inflammatory markers in our population of sedentary overweight/obese women, leptin was not a predictor of inflammatory markers. Thus, the observed relationship between PAEE and inflammatory markers was independent of leptin and fat mass.…”

Section: Discussionmentioning

confidence: 99%

Association between physical activity energy expenditure and inflammatory markers in sedentary overweight and obese women

et al. 2010

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Objective: Chronic subclinical inflammation and regular physical activity have opposing relationships to obesity-related metabolic diseases. Yet, the association between chronic inflammation and physical activity has rarely been examined in obese subjects. We examined the association between physical activity energy expenditure (PAEE), total (TEE) and resting energy expenditure (REE) and cardiorespiratory fitness (VO 2 peak) with inflammatory markers in overweight/obese women. Design: Cross-sectional study. Methods: The study included 152 overweight/obese postmenopausal women who were sedentary and free of chronic/ inflammatory diseases (mean age: 57.5 (95% confidence interval (CI) 56.7-58.3) years, body mass index (BMI): 32.5 (95% CI 31.8-33.2) kg m À2 ). The following parameters were measured: TEE (doubly labeled water), REE (indirect calorimetry), PAEE (as (TEE Â 0.90)ÀREE), VO 2 peak (ergocycle) and serum high-sensitive C-reactive protein (hsCRP), haptoglobin, soluble tumor necrosis factor-a receptor 1 (sTNFR1), interleukin-6, orosomucoid and white blood cells. Results: Sedentary women with the highest tertile of PAEE (1276 (1233-1319) kcal day À1 ) had lower concentrations of hsCRP and haptoglobin than those in the lowest tertile (587 (553-621) kcal day À1 ) after adjustment for fat mass (Po0.05). Soluble TNFR1 was positively correlated with VO 2 peak, TEE and REE (Po0.05), and hsCRP and orosomucoid were positively associated with REE (Po0.01), whereas haptoglobin was negatively associated with PAEE (Po0.05). In stepwise regression analyses that examined the concomitant associations of components of energy expenditure with inflammatory markers, PAEE remained the only predictor of hsCRP and haptoglobin (Po0.05), explaining 14 and 5%, respectively, of their variation,whereas REE was the only predictor of orosomucoid (r 2 ¼ 0.05, P ¼ 0.02) after adjustment for fat mass. Adding leptin to the regression models results in similar relationships between inflammatory markers and components of energy expenditure. Conclusion: PAEE is an independent predictor of hsCRP and haptoglobin in sedentary overweight/obese postmenopausal women free of chronic disease. Our data support the role of physical activity in reducing subclinical inflammation and risk of metabolic and cardiovascular diseases.

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Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals

Cited by 197 publications

References 61 publications

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors

Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition

Association between physical activity energy expenditure and inflammatory markers in sedentary overweight and obese women

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