Increased ischemia-modified albumin levels in patients with gastric cancer

Fidan, Evren; Menteşe, Ahmet; Kavgacı, Halil; Örem, Asım; Fidan, Serdal; Uzun, Abdullah; Özdemir, Feyyaz; Aydın, Faruk

doi:10.4149/neo_2012_051

Cited by 30 publications

(31 citation statements)

References 14 publications

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“…There are only a few studies evaluating the relationship between cancer and serum IMA levels. Fidan et al (2012) showed that serum IMA levels were increased in patients with gastric cancer, but they did not evaluate the serum albumin levels. Mastella et al (2009) found increased serum IMA levels in patients with prostate cancer, but this increase was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…There are various data on IMA in patients with different states with ischemia of non-cardiac origin such as systemic sclerosis, peripheral vascular disease, skeletal muscle ischemia, glaucoma and diabetes mellitus Montagnana et al, 2006;Piwowar et al, 2008). Also, serum IMA levels are increased in patients with gastric, prostate, neuroblastoma and soft tissue cancer (Mastella et al, 2009;StachowiczStencel et al, 2011;Fidan et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Also, serum IMA levels increased in patients with gastric, prostate, soft tissue cancer and neuroblastoma (Mastella et al, 2009;Stachowicz-Stencel et al, 2011;Fidan et al, 2012). There is no published report about serum concentrations of IMA in patients with BC.…”

Section: Introductionmentioning

confidence: 99%

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Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…İMA gastrik, prostat, yumuşak doku kanserleri ve nöroblastomlarda artmıştır. Fidan ve arkadaş-larının mide kanserli hastalarda, Stachowicz-Stencel ve arkadaşlarının nöroblastoma ve sarkomalı çocuklarda, Ellidag ve arkadaşlarının mesane kanserli ve kolorektal kanserli hastalarda yaptıkları çalışmalarında İMA'nın artmış olduğu gösteril-di (10,(45)(46)(47) .…”

Section: Kalp Dişi İskemi̇k Hastaliklarunclassified

A New Marker for Ischemia: Ischemia-modified Albumin

Can¹,

Yosunkaya²

2017

Kosuyolu Heart Journal

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ÖZETİskemi modifiye albumin iskemi sonucu oluşan reaktif oksijen türevlerinin yol açtığı albuminde modifikasyon ile oluşur. Albumin kobalt bağlama testi kullanılarak ölçülür. Bu test geçici olmayan kardiyak hasarın başlan-gıcından önce iskeminin erken saptanmasında kullanılır. Bu yazıda iskemi modifiye albuminin patofizyolojisi, analizi ve klinik uygulamalarını inceledik.Anahtar Kelimeler: İskemi modifiye albumin; iskemi; akut koroner sendrom A New Marker for Ischemia: Ischemia-modified Albumin ABSTRACT Ischemia-modified albumin constitutes via a modifcation in albumin where reactive oxygen species are formed due to ischemia. Albumin is measured using the cobalt binding test, and this test is used for the determination of albumin prior to the development of permanent cardiac injuries. In this review, we investigated the pathophysiology, analysis and clinical utility of ischemia-modified albumin.

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“…Some of these studies also define the decision values regarding the presence or absence of acute coronary syndrome in patients who come to the emergency service with acute chest pain [4,5]. On the other hand, there are also studies stating that IMA levels increase in pathologies other than acute coronary syndromes and they may be a diagnostic marker in these pathologies as well [6][7][8][9]. In fact, some of these studies also suggested IMA as a marker for oxidative stress [10,11].…”

Section: Introductionmentioning

confidence: 99%

The Reference Values Of Ischemia Modified Albumin Levels In Healthy People Admitted To A University Hospital

Duman¹,

Bakar²,

Eşsizoğlu³

et al. 2014

Turk J Bioch

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The reference values of ischemia modified albumin levels in healthy people admitted to a university hospital [ Methods: This study was performed on 582 people over 15 years old and healthy in appearance who had presented at the Çanakkale Onsekiz Mart University Faculty of Medicine Research and Application Hospital. The year 2011 population of Turkey was taken as the reference in the distribution of the study group according to age group and gender. A survey which queried the demographic features and health problems was administered to the participants of the study and 9 cc venous blood was drawn. IMA levels were measured by using the spectrophotometric method defined by Bar-Or. The mean, standard deviation, median, minimum, maximum, and 2.5 % -97.5 % interval were used in order to detect the IMA reference values. Results: A total of 274 males (47.1 %) and 308 women (52.9 %) were studied. The mean IMA value of the examined group was 0.339 ± 0.093, and the median was 0.343 (Min-Max: 0.053-0.631), while the 2.5 % -97.5 % percentil values were 0.145 -0.530. Conclusion: Studies that indicate the reference levels of the IMA for the diagnosis of ischemic conditions are insufficient. Our study is expected to contribute to closing this gap. Key Words: Ischemia, Ischemia-modified albumin, Reference range Conflict of Interest: The authors do not have a conflict of interest regarding the subjects related to this manuscript. ÖZETAmaç: İskemi modifiye albumin (IMA) akut koroner sendromun tanısında potansiyel kullanımı olabilecek bir miyokardiyal iskemi belirtecidir. Bu çalışmada amacımız Çanakkale Onsekiz Mart Üniversitesi'ne başvuran 15 yaşın üzerindeki sağlıklı insanlarda IMA testinin referans değerlerini belirlemektir. Gereç ve Yöntemler: Bu çalışma Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi Araş-tırma ve Uygulama Hastanesine başvuran 15 yaş ve üzeri ve görünürde sağlıklı 582 kişi üze-rinde gerçekleştirilmiştir. Çalışma grubunun yaş ve cinsiyet dağılımı belirlenirken 2011 yılı Türkiye nüfusu referans olarak alınmıştır. Katılımcılara demografik özelliklerinin ve sağlık problemlerinin sorgulandığı bir anket formu uygulandı ve 9 ml venöz kan alınmıştır. IMA düzeyleri Bar-Or tarafından tanımlanan spektrofotometrik metot kullanılarak ölçülmüştür. IMA referans değerlerini saptamak için ortalama, standart sapma, ortanca, minimum, maksimum ve % 2,5 -% 97,5 persentil değeri kullanılmıştır. Bulgular: Toplamda 274 erkek (% 47,1) ve 308 kadın (% 52,9) değerlendirildi. Çalışılan grupta ortalama IMA değeri 0,339 ± 0,093, ortanca değeri 0,343 (Min-Maks: 0,053 -0,631), % 2,5 -% 97,5 persentil değeri 0,145-0,530'dir. Sonuçlar: İskemik durumların tanısında IMA'nın referans değerlerini vurgulayan çalışmalar yetersizdir. Bizim çalışmamızın bu açığı kapatmaya katkıda bulunacağını beklemekteyiz. Anahtar Kelimeler: İskemi, İskemi Modifiye Albumin, Referans aralık Çıkar Çatışması: Yazarların makale konusu dâhilinde herhangi bir çıkar çatışmaları bulunmamaktadır.

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Increased ischemia-modified albumin levels in patients with gastric cancer

Cited by 30 publications

References 14 publications

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

A New Marker for Ischemia: Ischemia-modified Albumin

The Reference Values Of Ischemia Modified Albumin Levels In Healthy People Admitted To A University Hospital

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