Increased Intraocular Pressure After Third Ventricle Injections of Prostaglandin E1 and Arachidonic Acid

Effect of statin drugs and aspirin on progression in open‐angle glaucoma suspects using confocal scanning laser ophthalmoscopy

“…Another explanation is that the mechanisms of action of statins and aspirin in glaucoma progression, which are not yet fully elucidated, may exert a differential effect on the optic nerve. It is likely that aspirin may not prevent glaucoma development as we had hypothesized; its action as a cyclo‐oxygenase inhibitor decreases prostaglandin production, which may theoretically increase IOP 35,36 . Though all of our subjects remained normotensive by design, there may nevertheless be a subtle competing effect between aspirin and statins on glaucoma progression.…”

Intraocular pressure

“…296,297 In a similar fashion, adrenergic agonists and cyclic adenosine monophosphate are capable of reducing IOP. [305][306][307] Changes in IOP seem to mirror changes in intracranial and cerebrospinal fluid pressure and some have suggested that IOP could be used as a marker for increased or decreased intracranial pressure in patients with known intracranial pathology. Stimulation of the third cranial nerve reduces IOP.…”

The Intraocular Pressure

“…Thus injection of calcium (Krupin et αϊ, 1978) raised the intraocular pressure, an effect that could be reduced by acetazoleamide; hypertonic solutions de creased whilst hypotonic solutions increased the pressure (Krupin et al, 1973); finally prostaglandins of the Ε series elevated intraocular pressure (Krupin et al, 1976), an effect that was not blocked by aspirin. Becker and his colleagues have made several studies of the effects of such injections on the intraocular pressure of rabbits.…”