Effect of statin drugs and aspirin on progression in open‐angle glaucoma suspects using confocal scanning laser ophthalmoscopy

Castro, Dawn K. De; Punjabi, Omar S.; Bostrom, Alan; Stamper, Robert L.; Lietman, Thomas M.; Ray, Kathryn J.; Lin, Shan

doi:10.1111/j.1442-9071.2007.01529.x

Cited by 54 publications

(54 citation statements)

References 39 publications

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“…First, the authors stated that the studies by De Castro et al 4 and Leung et al 6 consisted of representative or somewhat representative samples of statin users in the selection domain. However, the representativeness of both studies is uncertain because they were conducted in university-based eye centers where the population coverage was not described.…”

Section: The Process Of Appraising the Quality Of Evidence Of The Incmentioning

confidence: 99%

“…The authors categorized the patients in the study by Stein et al 5 who had conversion from suspected glaucoma to definite glaucoma, as well as the patients in the study by De Castro et al 4 who had within-normal-limits result on the glaucoma hemifield test at the start of study (i.e., open-angle glaucoma [OAG] suspect as defined in the study) but outside normal limits at the last visit (i.e., OAG case as defined in the study) as having glaucoma progression. They also categorized the patients with normal-tension glaucoma in the study by Leung et al 6 who had visual field defect at the start of the study and visual field progression at the end of the study as having glaucoma progression.…”

Section: Placement Of Studies In the Meta-analysismentioning

confidence: 99%

“…However, De Castro et al 4 stated that the data on statin and aspirin exposure were collected from medication history of medical records and confirmed by phone call. Our point of view is to consider only prescription records from a pharmacy or computerized network as ''secure records'' of exposure, as well demonstrated in the remaining included cohort studies.…”

Section: The Process Of Appraising the Quality Of Evidence Of The Incmentioning

confidence: 99%

“…It determines whether studies regarding the conversion from suspected glaucoma to definite glaucoma 4,5 should be assigned to the outcome of glaucoma incidence or glaucoma progression in the meta-analysis. This in turn alters the conclusion of the metaanalysis.…”

Section: Placement Of Studies In the Meta-analysismentioning

confidence: 99%

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Statin Use and Open-Angle Glaucoma: Evidence From Observational Studies

Fung

Chan

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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We read with interest the systematic review and meta-analysis on the effect of statins on intraocular pressure (IOP) and glaucoma incidence and progression by McCann et al. 1 We would like to discuss the appropriateness of inclusion of studies in the systematic review, placement of studies in the metaanalysis, and the process of appraising the quality of evidence of the included studies. APPROPRIATENESS OF INCLUSION OF STUDIES IN THE SYSTEMATIC REVIEWThe authors claim that the systematic review was to evaluate the effect of statins on glaucoma; the inclusion of studies with nonglaucoma cases could lead to erroneous conclusions. The authors included the case-control study by Owen et al., 2 which defined cases based on a combination of diagnostic codes for glaucoma or ocular hypertension and codes for prescription specific to glaucoma treatment. In the definition of glaucoma, ocular hypertension is not a subtype of glaucoma. There was also a lack of information on the proportion of cases with a diagnostic code of ocular hypertension in the study. With the large uncertainty on the proportion of cases with glaucoma, this case-control study must be excluded from both the systematic review and meta-analysis.In addition, one of the purposes of the systematic review was to

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Section: The Process Of Appraising the Quality Of Evidence Of The Incmentioning

confidence: 99%

Section: Placement Of Studies In the Meta-analysismentioning

confidence: 99%

Section: The Process Of Appraising the Quality Of Evidence Of The Incmentioning

confidence: 99%

Section: Placement Of Studies In the Meta-analysismentioning

confidence: 99%

See 2 more Smart Citations

Statin Use and Open-Angle Glaucoma: Evidence From Observational Studies

Fung

Chan

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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show abstract

“…4 Also, in a study by De Castro et al, it was reported that the use of statins for at least 23 months showed optic nerve head changes suggestive of a protective effect against glaucoma progression and RNFL thickness. 5 Therefore, it would be better to consider the medication status while performing RVC, OPA, RNFL and macular thickness measurements.…”

Section: Sirmentioning

confidence: 99%

Appropriate evaluation of ocular parameters in coronary artery bypass grafting surgery patients

Özgönül¹,

Sertoğlu²,

Özge

et al. 2015

Perfusion

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Diabetes, Metabolic Abnormalities, and Glaucoma

Tan

Wong²,

Fong³

et al. 2009

Arch Ophthalmol

109

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Objective: To examine the relationship of diabetes mellitus and metabolic abnormalities with intraocular pressure and glaucoma. Methods: A population-based study was conducted in 3280 (78.7% response) Malay adults aged 40 to 80 years. Diabetes was defined as a random serum glucose level of 200 mg/dL or greater or physician diagnosis of diabetes mellitus. Metabolic abnormalities including body mass index, lipid levels, and blood pressure were measured. Glaucoma was defined from a standardized examination by means of the International Society for Geographical and Epidemiological Ophthalmology criteria. Results: There were 764 persons (23.3%) who had diabetes. After controlling for age, sex, education, smoking, central corneal thickness, and diabetes treatment, intraocular pressure was higher in persons with than without diabetes (16.7 vs 15.0 mm Hg, PϽ.001) and in those with higher serum glucose levels (P Ͻ .001), glycosylated hemoglobin concentrations (PϽ.001), total cholesterol levels (P=.001), triglyceride levels (P=.002), and body mass index (P =.001). However, the prevalence of glaucoma was similar between persons with and without diabetes (4.7% vs 4.5%). In multivariate logistic regression models adjusting for age, sex, education, smoking, central corneal thickness, and diabetes treatment, diabetes was not associated with glaucoma (odds ratio, 1.00; 95% confidence interval, 0.63-1.61). Conclusion: These data suggest that, although diabetes and metabolic abnormalities may be associated with a small increase in intraocular pressure, they are not significant risk factors for glaucomatous optic neuropathy.

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Effect of statin drugs and aspirin on progression in open‐angle glaucoma suspects using confocal scanning laser ophthalmoscopy

Abstract: Statin drugs may be associated with slowed progression of optic nerve parameters in glaucoma suspects as measured by CSLO.

Cited by 54 publications

References 39 publications

Statin Use and Open-Angle Glaucoma: Evidence From Observational Studies

Statin Use and Open-Angle Glaucoma: Evidence From Observational Studies

Appropriate evaluation of ocular parameters in coronary artery bypass grafting surgery patients

Diabetes, Metabolic Abnormalities, and Glaucoma

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