Increased intima-media thickness in rayon workers after long-term exposure to carbon disulfide

Schramm, Axel; Uter, Wolfgang; Brandt, M; Göen, Thomas; Köhrmann, Martin; Baumeister, Thomas; Drexler, Hans

doi:10.1007/s00420-015-1091-5

Cited by 6 publications

(8 citation statements)

References 30 publications

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“…The level of urinary TTCA may reflect the exposure of the day. There was a linear correlation between TTCA values in urine and the CS 2 values in the atmosphere [22].…”

Section: Neuro-and Cardiotoxicity Of Csmentioning

confidence: 77%

“…Chronic exposure to CS 2 may induce polyneuropathy, Parkinson and neuro-psychological symptoms [18]. Long-term exposure to high concentrations of CS 2 could lead to the damage of nervous system, elevate blood pressure and promote the development and progression of hyperlipemia and atherosclerosis [22].…”

Section: Neuro-and Cardiotoxicity Of Csmentioning

confidence: 99%

“…Intima-media thickness of the carotid arteries (IMT) represents an established marker of atherosclerosis and a reasonable surrogate marker for cardiovascular risk. Intima-media thickness was examined in a large cohort of CS 2 -exposed workers and the association with cumulative CS 2 exposure was analyzed [22].…”

Section: Neuro-and Cardiotoxicity Of Csmentioning

confidence: 99%

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Health effect of chronic exposure to carbon disulfide (CS<sub>2</sub>) on women employed in viscose industry

Sieja¹,

Mach-Szczypiński²,

Mach-Szczypiński³

2018

Med Pr

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Many women are exposed to carbon disulfide (C2) hazards at work every day. Working with C2 may cause some women to experience abnormalities in their reproductive health. Until now obtained data is generally concentrated on the health effects of C2 observed in the viscose industry. To date, C2 has not been studied precisely for its potential to have damaging effects on female reproductive system, especially the frequency of menstrual disturbances and the course of menopause. The aim of the study was to sum up female reproductive health hazards amongst women chronically exposed to C2 in their workplace in the viscose industry. In order to study the effect of C2 in the contemporary viscose industry, exposure measurements should be collected in prospective or cross-sectional studies. In conclusion, reproductive health hazards for women chronically exposed to C2 in the workplace in the viscose industry are the following: 1) menstrual disorders essentially are more frequent than in the case of the healthy women, 2) for women chronically exposed to C2 the average menopausal age is statistically earlier, as compared to healthy women, 3) complex disturbances in neurohormonal system for women exposed to C2, resulting from toxic influences of C2, which cause the secretion of estrogens and progesterone in ovaries and dehydroepiandrosterone sulfate in the adrenal gland to diminish. Med Pr 2018;69(3):329-335.

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“…The level of urinary TTCA may reflect the exposure of the day. There was a linear correlation between TTCA values in urine and the CS 2 values in the atmosphere [22].…”

Section: Neuro-and Cardiotoxicity Of Csmentioning

confidence: 77%

Section: Neuro-and Cardiotoxicity Of Csmentioning

confidence: 99%

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Health effect of chronic exposure to carbon disulfide (CS<sub>2</sub>) on women employed in viscose industry

Sieja¹,

Mach-Szczypiński²,

Mach-Szczypiński³

2018

Med Pr

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“…30,194,195 Few studies account for chronic exposure 196 or the limits of quantification. CS 2 exposure has largely been assessed via detection of the urinary metabolite TTCA (Scheme 4).…”

Section: Bodily Inventory Of Csmentioning

confidence: 99%

“…38,39 From a brief overview of the literature, the described toxicity, pathology, and/or metabolism of CS 2 indicate a breadth of targeted biochemical effects.…”

Section: Toxicitymentioning

confidence: 99%

Carbon disulfide. Just toxic or also bioregulatory and/or therapeutic?

et al. 2017

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The overview presented here has the goal of examining whether carbon disulfide (CS 2 ) may play a role as an endogenously generated bioregulator and/or has therapeutic value. The neuro-and reproductive system toxicity of CS 2 has been documented from its long-term use in the viscose rayon industry. CS 2 is also used in the production of dithiocarbamates (DTCs), which are potent fungicides and pesticides, thus raising concern that CS 2 may be an environmental toxin. However, DTCs also have recognized medicinal use in the treatment of heavy metal poisonings as well as having potency for reducing inflammation. Three known small molecule bioregulators (SMBs) nitric oxide, carbon monoxide, and hydrogen sulfide were initially viewed as environmental toxins. Yet each is now recognized as having intricate, though not fully elucidated, biological functions at concentration regimes far lower than the toxic doses. The literature also implies that the mammalian chemical biology of CS 2 has broader implications from inflammatory states to the gut microbiome. On these bases, we suggest that the very nature of CS 2 poisoning may be related to interrupting or overwhelming relevant regulatory or signaling process(es), much like other SMBs. TOC Image 1 CONTENTS

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Carbon disulfide

Khalid

Moradkhan

Bayrami

2024

Encyclopedia of Toxicology

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Increased intima-media thickness in rayon workers after long-term exposure to carbon disulfide

Abstract: Long-term CS2 exposure is an independent risk factor concerning IMT changes. The amount of IMT increase, in a similar range as that associated with other cardiovascular risk factors, might be clinically relevant.

Cited by 6 publications

References 30 publications

Health effect of chronic exposure to carbon disulfide (CS<sub>2</sub>) on women employed in viscose industry

Health effect of chronic exposure to carbon disulfide (CS<sub>2</sub>) on women employed in viscose industry

Carbon disulfide. Just toxic or also bioregulatory and/or therapeutic?

Carbon disulfide

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