Increased Interleukin-8 in Epithelial Lining Fluid of Collapsed Lungs During One-Lung Ventilation for Thoracotomy

Komatsu, Yoshimichi; Yamamoto, Hiroshi; Tsushima, Kenji; Furuya, Seiji; Yoshikawa, Sumiko; Yasuo, Masanori; Kubo, Keishi; Yamazaki, Yoshitaka; Hasegawa, Joh; Eguchi, Takashi; Kondo, Rie; Yoshida, Kazuo; Koizumi, Tomonobu

doi:10.1007/s10753-012-9505-y

Cited by 12 publications

(10 citation statements)

References 20 publications

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“…IL-1, 8, 10, 12, etc. [ 25 – 27 ] . However, we believe that the parameters we chose were sufficient to reveal lung injuries.…”

Section: Discussionmentioning

confidence: 99%

Oxygenation, inflammatory response and lung injury during one lung ventilation in rabbits using inspired oxygen fraction of 0.6 vs. 1.0

Bian

et al. 2017

J Biomed Res

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Maintaining adequate oxygenation during one-lung ventilation (OLV) requires high inspired oxygen fraction (FiO2). However, high FiO2 also causes inflammatory response and lung injury. Therefore, it remains a great interest to clinicians and scientists to optimize the care of patients undergoing OLV. The aim of this study was to determine and compare oxygenation, inflammatory response and lung injury during OLV in rabbits using FiO2 of 0.6 vs. 1.0. After 30 minutes of two-lung ventilation (TLV) as baseline, 30 rabbits were randomly assigned to three groups receiving mechanical ventilation for 3 hours: the sham group, receiving TLV with 0.6 FiO2; the 1.0 FiO2 group, receiving OLV with 1.0 FiO2; the 0.6 FiO2 group, receiving OLV with 0.6 FiO2. Pulse oximetry was continuously monitored and arterial blood gas analysis was intermittently conducted. Histopathologic study of lung tissues was performed and inflammatory cytokines and the mRNA and protein of nuclear factor kappa B (NF-κB) p65 were determined. Three of the 10 rabbits in the 0.6 FiO2 group suffered hypoxemia, defined by pulse oximetric saturation (SpO2) less than 90%. Partial pressure of oxygen (PaO2), acute lung injury (ALI) score, myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), mRNA and protein of NF-κB p65 were lower in the 0.6 FiO2 group than in the 1.0 FiO2 group. In conclusion, during OLV, if FiO2 of 0.6 can be tolerated, lung injury associated with high FiO2 can be minimized. Further study is needed to validate this finding in human subjects.

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“…IL-1, 8, 10, 12, etc. [ 25 – 27 ] . However, we believe that the parameters we chose were sufficient to reveal lung injuries.…”

Section: Discussionmentioning

confidence: 99%

Oxygenation, inflammatory response and lung injury during one lung ventilation in rabbits using inspired oxygen fraction of 0.6 vs. 1.0

Bian

et al. 2017

J Biomed Res

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“…Meanwhile, the thoracoscopic time with one lung ventilation (OLV) was significantly longer in the Thoracic group than in the Cervical group. OLV during the lung surgery was reported to be associated with an increased inflammatory response in the epithelium of the collapsed lung [15]. Therefore, the longer OLV might affect the incidence of pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Comparison between neck-first approach and thoracic approach during thoracoscopic esophagectomy

Kitagawa

Namikawa

Iwabu

et al. 2017

Langenbecks Arch Surg

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“…Lung collapse results in increased IL-8 levels in BAL fluid and the re-expansion of the lungs further increases IL-8 levels in rabbits [ 19 ]. One-lung ventilation resulted in an IL-8 increase in the ELF of the non-ventilated lungs [ 20 ]. These observations suggest that the increase in IL-8 levels in the ELF in the low V T group in the present study was due to a repeated lung collapse and re-opening of the lungs (atelectrauma) during surgery due to low V T ventilation concomitant with low PEEP.…”

Section: Discussionmentioning

confidence: 99%

Low tidal volume ventilation with low PEEP during surgery may induce lung inflammation

et al. 2015

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BackgroundCompared to conventional tidal volume ventilation, low tidal-volume ventilation reduces mortality in cased of acute respiratory distress syndrome. The aim of the present study is to determine whether low tidal-volume ventilation reduces the production of inflammatory mediators in the lungs and improves physiological status during hepatic surgery.MethodsWe randomly assigned patients undergoing hepatectomy into 2 groups: conventional tidal-volume vs. low tidal-volume (12 vs. 6 mL•kg−1 ideal body weight) ventilation with a positive end-expiratory pressure of 3 cm H2O. Arterial blood and airway epithelial lining fluid were sampled immediately after intubation and every 3 h thereafter.ResultsTwenty-five patients were analyzed. No significant changes were found in hemodynamics or acid–base status during the study. Interleukin-8 was significantly elevated in epithelial lining fluid from the low tidal-volume group. Oxygenation evaluated immediately after admission to the post-surgical care unit was significantly worse in the low tidal-volume group.ConclusionsLow tidal-volume ventilation with low positive end-expiratory pressure may lead to pulmonary inflammation during major surgery such as hepatectomy.Trial registrationThe effect of ventilatory tidal volume on lung injury during hepatectomy that requires transient liver blood flow interruption. UMIN000021371 (03/07/2016); retrospectively registered

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Increased Interleukin-8 in Epithelial Lining Fluid of Collapsed Lungs During One-Lung Ventilation for Thoracotomy

Cited by 12 publications

References 20 publications

Oxygenation, inflammatory response and lung injury during one lung ventilation in rabbits using inspired oxygen fraction of 0.6 vs. 1.0

Oxygenation, inflammatory response and lung injury during one lung ventilation in rabbits using inspired oxygen fraction of 0.6 vs. 1.0

Comparison between neck-first approach and thoracic approach during thoracoscopic esophagectomy

Low tidal volume ventilation with low PEEP during surgery may induce lung inflammation

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