Increased interleukin-10 levels correlate with bacteremia and sepsis in febrile neutropenia pediatric oncology patients

Urbonas, Vincas; Eidukaitė, Audronė; Tamulienė, Indrė

doi:10.1016/j.cyto.2011.11.012

Cited by 33 publications

(25 citation statements)

References 11 publications

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“…The increase in proinflammatory cytokines mainly TNF-α and IL-1β is well evident, as reported in other studies where increase in the level of these cytokine precedes C-reactive protein level [42]. The increase in IL-10 level in pediatric sepsis patient as compared to controls also depicts the severity of infection leading to sepsis, as reported in previous studies [43]. The increase in the nitrite level in PMNs isolated from pediatric sepsis patient as compared to controls depicts that increase in nitric oxide level leads to vasodilatation of endothelium, which increases hypotension and produces the condition of septic shock.…”

Section: Discussionsupporting

confidence: 54%

Candidemia-induced pediatric sepsis and its association with free radicals, nitric oxide, and cytokine level in host

Kumar

Singh

et al. 2015

Journal of Critical Care

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Section: Discussionsupporting

confidence: 54%

Candidemia-induced pediatric sepsis and its association with free radicals, nitric oxide, and cytokine level in host

Kumar

Singh

et al. 2015

Journal of Critical Care

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“…Organisms isolated from blood culture included Escherichia coli (2), Enterobacter spp. (2), Klebsiella pneumonia (1) and Staphylococcus aureus (1). Aspergillus was isolated from maxillary sinus in one episode.…”

Section: Resultsmentioning

confidence: 99%

“…Timely and dependable identification of low-risk patients will facilitate decision for avoiding antibiotics; thus, reducing cost as well as antibiotic resistance. [1] Cytokines are polypeptides released by activated monocytes and macrophages that mediate a Investigations at admission included a blood count and bacterial culture. Radiological investigations and cultures from other body fluids were obtained as clinically relevant.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-5, interleukin-6, interleukin-8 and tumour necrosis factor-alpha levels obtained within 24-h of admission do not predict high-risk infection in children with febrile neutropenia

Aggarwal

Bansal

et al. 2013

Indian Journal of Medical Microbiology

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“…), and/or signs of multiple organ dysfunction or failure (e.g., alteration of mental status, hypotension, oliguria, increase in transaminases, bilirubin, disseminated intravascular coagulation etc.) [13]. Fever of unknown origin (FUO) was defined as a febrile episode with confirmed negative blood culture, absence of sepsis, and clinically or microbiologically documented local infection.…”

Section: Methodsmentioning

confidence: 99%

“…IL-6, IL-8, and IL-10 have been shown to have good negative predictive value for bacteraemia in adult and paediatric oncology patients [4,6,13]. Some of them are perspective for further optimize the risk assessment model, because there is no generally accepted method that can rapidly differentiate between paediatric oncology patients with febrile neutropenia (FN) who are at high risk for developing adverse events (AEs) and those at low risk for AEs [14].…”

mentioning

confidence: 99%

The role of CRP, PCT, IL-6 and presepsin in early diagnosis of bacterial infectious complications in paediatric haemato-oncological patients

Plesko¹,

Suvada²,

Makohusová³

et al. 2016

neo

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Bacterial infection is the most common complication in paediatric oncological patients during cancer treatment. A suitable tool for early prediction of unfavourable course of infection is still needed. We performed a prospective longitudinal observational study to evaluate of the role of serum biomarkers (C-reactive protein, procalcitonin, interleukin-6, presepsin) in the early diagnosis of bacteraemia (gram-negative versus gram-positive) in patients with haematological malignancies. We observed 69 febrile episodes in 33 patients (17 male, 16 female; 1.5-18.9 years, mean 7.31 years, median 5 years). Within this sample, there were 22 cases of positive blood cultures, 16 cases of sepsis, 38 cases of fever with no signs or symptoms of sepsis, and two deaths from infectious complications. All markers tested had good negative predictive value (73% -93%). CRP was characterized by good specificity for registration bacteraemia (96%, 95% CI: 85% -99%), but other results were inconclusive. We identified comparably balanced sensitivity (64% -81%) and specificity (61% -88%) for interleukin-6 and procalcitonin, and we proved their quality to predict positive blood culture and clinical signs of sepsis as well. Patients with gram-negative bacteraemia had significantly elevated levels of PCT and IL-6 in comparison with a group of patients with gram-positive bacteraemia (p = 0.04 for PCT and p = 0.005 for IL-6). Presepsin was characterized by poor specificity (27%, 95% CI: 15% -43%) and positive predictive value (24%, 95% CI: 12 -39%) for predicting bacteraemia, and by better sensitivity (84%, 95% CI: 55% -98%) and specificity (58%, 95% CI: 42% -73%) for predicting clinical signs of sepsis. Key words: C-reactive protein, procalcitonin, interleukin-6, presepsin, fever, sepsisBacterial infection is the most common treatment-related complication in patients with haematological malignancies [1]. Documented mortality associated with paediatric febrile neutropenia is 2% [2]. The potential for early diagnosis of bacteraemia through serum biomarkers has been the subject to extensive research [3]. In 2012 Phillips et al published large meta-analysis of 25 studies exploring 14 different biomarkers in 3,585 episodes of febrile neutropenia. CRP, PCT and IL-6 were subject to quantitative meta-analysis. The bivariate estimates of diagnostic precision of these biomarkers and outcomes were done. Data were available for meta-analysis for CRP for microbiologically or clinically documented infection (results: cut off > 50mg/dl, sensitivity 65%, specificity 73%), for PCT assessing microbiologically or clinically documented infection (results: cut off > 0.2 mg/ml, sensitivity 96%, specificity 85%), for IL-6 reporting microbiologically or clinically documented infection (results: cut off > 235 pg/ml, sensitivity 68%, specificity 94%), and gram-negative bacteraemia (results: cut off > 1000 pg/ml, sensitivity 78%, specificity 96%). Huge inconsistencies and heterogeneity in the studies included in this review were the most important limiting factors [...

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Increased interleukin-10 levels correlate with bacteremia and sepsis in febrile neutropenia pediatric oncology patients

Cited by 33 publications

References 11 publications

Candidemia-induced pediatric sepsis and its association with free radicals, nitric oxide, and cytokine level in host

Candidemia-induced pediatric sepsis and its association with free radicals, nitric oxide, and cytokine level in host

Interleukin-5, interleukin-6, interleukin-8 and tumour necrosis factor-alpha levels obtained within 24-h of admission do not predict high-risk infection in children with febrile neutropenia

The role of CRP, PCT, IL-6 and presepsin in early diagnosis of bacterial infectious complications in paediatric haemato-oncological patients

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