Interleukin-5, interleukin-6, interleukin-8 and tumour necrosis factor-alpha levels obtained within 24-h of admission do not predict high-risk infection in children with febrile neutropenia

Aggarwal, Ritu; Bansal, Deepak; Bansal, Frainey; Nanda, Neha; Ray, Pallab; Trehan, Amita; Marwaha, R. K.

doi:10.4103/0255-0857.115624

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…In patients with periodontitis, LI-6 and IL-8 are abnormally elevated, and IL-6 in the cerebrospinal fluid after subarachnoid hemorrhage can predict infection (27,30,52). This seems to indicate that the increase in IL- (1,10,56,57). Their research, as well as ours, have revealed the benefits of cytokines IL-6, IL-8, and IL-10 in accurately predicting infections with a short detection time and high sensitivity.…”

Section: Discussionsupporting

confidence: 56%

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Cytokine Expression of Lung Bacterial Infection in Newly Diagnosed Adult Hematological Malignancies

Guan

Zhang

et al. 2021

Front. Immunol.

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Adult patients with hematological malignancies are frequently accompanied by bacterial infections in the lungs when they are first diagnosed. Sputum culture, procalcitonin (PCT), C-reactive protein (CRP), body temperature, and other routinely used assays are not always reliable. Cytokines are frequently abnormally produced in adult hematological malignancies associated with a lung infection, it is uncertain if cytokines can predict lung bacterial infections in individuals with hematological malignancies. Therefore, we reviewed 541 adult patients newly diagnosed with hematological malignancies, of which 254 patients had lung bacterial infections and 287 patients had no other clearly diagnosed infections. To explore the predictive value of cytokines for pulmonary bacterial infection in adult patients with hematological malignancies. Our results show that IL-4, IL-6, IL-8, IL-10, IL-12P70, IL-1β, IL-2, IFN-γ, TNF-α, TNF-β and IL-17A are in the lungs The expression level of bacterially infected individuals was higher than that of patients without any infections (P<0.05). Furthermore, we found that 88.89% (200/225) of patients with IL-6 ≥34.12 pg/ml had a bacterial infection in their lungs. With the level of IL-8 ≥16.35 pg/ml, 71.67% (210/293) of patients were infected. While 66.10% (193/292) of patients had lung bacterial infections with the level of IL-10 ≥5.62 pg/ml. When IL-6, IL-8, and IL-10 were both greater than or equal to their Cutoff-value, 98.52% (133/135) of patients had lung bacterial infection. Significantly better than PCT ≥0.11 ng/ml [63.83% (150/235)], body temperature ≥38.5°C [71.24% (62/87)], CRP ≥9.3 mg/L [53.59% (112/209)] the proportion of lung infection. In general. IL-6, IL-8 and IL-10 are abnormally elevated in patients with lung bacterial infections in adult hematological malignancies. Then, the abnormal increase of IL-6, IL-8 and IL-10 should pay close attention to the possible lung bacterial infection in patients.

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Section: Discussionsupporting

confidence: 56%

“…The Cut-off values for IL-6, IL-8, and IL-10 reported by different researchers differ slightly ( 1 , 10 , 56 , 57 ). Their research, as well as ours, have revealed the benefits of cytokines IL-6, IL-8, and IL-10 in accurately predicting infections with a short detection time and high sensitivity.…”

Section: Discussionmentioning

confidence: 88%

Cytokine Expression of Lung Bacterial Infection in Newly Diagnosed Adult Hematological Malignancies

Guan

Zhang

et al. 2021

Front. Immunol.

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“…Factors affecting lung injury and lung infection mainly include hyperactivity of oxygen free radicals and inflammatory response, and the single-lung ventilation process during surgery can lead to the release of various cytokines, thus triggering systemic inflammatory response [9]. IL-6 and IL-10, as markers of tissue damage, are significantly correlated with the degree of surgical trauma and inflammatory response, as well as postoperative recovery of patients [10]. In this study, target-directed fluid therapy was found to be associated with a decrease in IL-6 and IL-10 levels, suggesting that target-directed fluid therapy may help suppress excessive inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Targeted Fluid Therapy on Patients with One-Lung Ventilation

Zhao

Xia

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To evaluate the protective effect of target-directed fluid therapy on the lungs and postoperative rehabilitation in elderly patients with single-lung ventilation undergoing total endoscopic radical resection of esophageal cancer. Methods. Seventy elderly patients who underwent total endoscopic radical resection of esophageal cancer from January 2017 to December 2019 in our hospital were selected and divided into two groups by the random number table method: the goal-directed fluid treatment group (group G, n = 35) and the control group (group C, n = 35). Venous blood was extracted before surgery (T1), at the end of free esophagus (T2) by thoracoscopy, at the end of abdominal surgery (T3), and at the end of surgery (T4). IL-6 and IL-10 levels were detected by ELISA. The clinical pulmonary infection score (CIPS) was used to evaluate the pulmonary inflammation on the second day after surgery and the occurrence of complications. Duration of antibiotic use and length of hospital stay were recorded. Results. At T1, there were no significant differences in IL-6 and IL-10 levels between the two groups ( P > 0.05 ). At T2, the IL-6 level in group G increased to 26.65 ± 1.80 pg/ml but was significantly lower than that in group C (32.28 ± 3.22 pg/ml) ( P < 0.01 ). At T3 and T4, IL-6 and IL-10 levels in group G were significantly lower than those in group C ( P < 0.01 ). The CIPS score of group G was lower than that of group C (1.5 ± 1.0 vs 2.7 ± 1.4), and the duration of antibiotic use in group G was shorter than that in group C (211.2 ± 15.4 vs 232.6 ± 18.7 h), with statistical significance ( P < 0.01 ). The incidence of complications in group G was lower than that in group C (28.6% vs 40.0%), and the length of hospital stay in group G was shorter than that in group C (10.5 ± 1.7 vs 11.2 ± 1.9 days), but there was no significant difference between the two groups ( P > 0.05 ). Conclusion. Target-directed fluid therapy inhibited inflammatory cytokine levels and had better lung protection, but no significant benefit in the complications or the length of hospital stay was observed.

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“…Many cytokines have been studied to identify a marker which could stratify infectious risk in children with FN, but their role is still evolving. The most studied markers are procalcitonin (PCT), CRP, interleukin (IL)-6, IL-8, and IL-10, which are usually involved in the inflammatory mechanisms [ 48 , 49 , 50 , 51 ]. Interestingly, lactate was not explored as a diagnostic biomarker, although it represents a risk factor for septic shock and mortality [ 52 ].…”

Section: Markers Of Infections In Febrile Neutropeniamentioning

confidence: 99%

Update on Febrile Neutropenia in Pediatric Oncological Patients Undergoing Chemotherapy

et al. 2021

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Febrile neutropenia (FN) is a common complication of chemotherapy in oncological children and one of the most important causes of morbidity and mortality in these patients. The early detection of a bacteremia and the rapid therapeutic intervention are crucial to improve the outcome. We analyzed the literature in order to clarify the epidemiology of FN in children undergoing chemotherapy, the specific factors associated with a negative outcome, the most common etiology, and the value of biological markers as a tool to make an early diagnosis or to monitor the evolution of the infection. Several studies have tried to identify specific factors that could help the clinician in the detection of an infection and in its microbiological identification. However, due to the heterogenicity of the available studies, sufficient evidence is lacking to establish the role of these risk factors in clinical practice and future research on this topic appear mandatory. Determinations of risk factors, etiology, and markers of febrile episodes in these patients are complicated by the characteristics of the underlying illness and the effects of treatments received. Although some studies have tried to develop an evidence-based guideline for the empiric management of FN in pediatrics, validated predictive scores and algorithms are still lacking and urgently needed.

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Interleukin-5, interleukin-6, interleukin-8 and tumour necrosis factor-alpha levels obtained within 24-h of admission do not predict high-risk infection in children with febrile neutropenia

Abstract: IL-5, IL-6, IL-8 and TNF-α failed as predictors of clinically localised or microbiologically documented infection in children with chemotherapy induced FN. However, IL-6, IL-8 and TNF-α could be useful in excluding the possibility of high-risk infection.

Cited by 8 publications

References 19 publications

Cytokine Expression of Lung Bacterial Infection in Newly Diagnosed Adult Hematological Malignancies

Cytokine Expression of Lung Bacterial Infection in Newly Diagnosed Adult Hematological Malignancies

Protective Effect of Targeted Fluid Therapy on Patients with One-Lung Ventilation

Update on Febrile Neutropenia in Pediatric Oncological Patients Undergoing Chemotherapy

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