Increased Insulin Receptors after Exercise in Patients with Insulin-Dependent Diabetes Mellitus

Pedersen, Oluf; Beck‐Nielsen, Henning; Hedïng, Lise G.

doi:10.1056/nejm198004173021603

Cited by 171 publications

(56 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Physical training has mostly been shown to improve insulin sensitivity in healthy humans regardless of age [82,[98][99][100][101], in obese non-diabetic subjects [102,103], in both patients with insulin-dependent diabetes and NIDDM [104][105][106][107]. Regular exercise is also beneficial in older subjects and improves insulin sensitivity even to levels typical of younger individuals, independent of changes in weight and body composition [99][100][101].…”

Section: Insulin Resistancementioning

confidence: 99%

Exercise and the metabolic syndrome

1997

View full text Add to dashboard Cite

One of the first people to introduce the metabolic syndrome -or trisyndrome mé tabolique -in the scientific literature was Camus in 1966 [1]. However, this entity did not receive much interest until Reaven in 1988 introduced syndrome X, characterised by hypertension, impairment in glucose and lipid metabolism and insulin resistance [2]. The metabolic syndrome -also called the insulin resistance syndrome -is a multifaceted syndrome characterised by five major abnormalities: obesity, hypertension, insulin resistance, glucose intolerance (impaired glucose tolerance/non-insulin-dependent diabetes mellitus (NIDDM)), and dyslipidaemia (hypertriglyceridaemia and low HDL-cholesterol). In addition, a number of other abnormalities such as microalbuminuria, hyperuricaemia, hyperfibrinogenaemia and increased levels of plasminogen activator inhibitor I and low concentrations of tissue plasminogen activator are often associated with the syndrome. The clinical importance of the metabolic syndrome is mainly due to the clustering of simultaneously occurring atherosclerotic risk factors in the same individual [2][3][4][5][6][7][8][9].The aetiology of the metabolic syndrome is poorly understood; both genetic and environmental factors are involved [2][3][4][5][6][7][8][9]. Possible common denominators for the various components of the syndrome are not known, although hyperinsulinaemia/insulin resistance are important characteristics in most of the abnormalities.The prevalence rate of the metabolic syndrome varies depending on the population studied and the definition applied. As in any syndrome, not all features are present in the same individual. The estimated prevalence rate of the metabolic syndrome in western countries is 25-35 % [2-9]. On the other hand, both Ferrannini and Rupp [8, 9] have reported that only about one-third of an adult study population was free of all major characteristics of the metabolic syndrome. Since the prevalence of hypertension, insulin resistance and glucose intolerance usually increase with increasing age, the prevalence of the metabolic syndrome will probably also rise in the aging western society.A number of pharmacological therapies can be used for the treatment of the metabolic syndrome; but the results of most of the available therapies are often unsatisfactory, although some trials with metformin and thiazolidinediones have been encouraging [6, 10, 11].Low levels of physical activity are related to most components of the metabolic syndrome [12][13][14][15][16]. Consequently this offers a unique opportunity to employ increased physical activity in the prevention and treatment of the metabolic syndrome and its components. This review will focus on the role of physical activity and exercise in the prevention and treatment of the metabolic syndrome. ObesityThe prevalence of obesity (body mass index (BMI) > 27 kg/m 2 ) is currently 25-35 % in most western societies, and is increasing [17]. If the prevalence continues to increase, as during the past decades, by the year 2230, 100 % of the adult Uni...

show abstract

Section: Insulin Resistancementioning

confidence: 99%

Exercise and the metabolic syndrome

1997

View full text Add to dashboard Cite

show abstract

“…The Insulin receptor may be altered in many common situations, s well s in rare disorders, or situations accompanied by Insulin resistance such s diabetes (2,20,32,55), obesity (4), acromegaly (56), acanthosis nigricans (7), anorexia nervosa (27,42), uraemia (57), ataxia telangiectasia (6), pregnancy (9,34,35,58) and during the menstrual cycle (33,59,60).…”

Section: Introductionmentioning

confidence: 99%

Insulin Binding to Erythrocytes from Pregnant, Postpartum, Follicular and Luteal States

Dwenger¹,

Mitzkat²,

Holle³

et al. 1982

CCLM

View full text Add to dashboard Cite

By using a modified Scatchard analysis, statistically significant differences were observed between the receptor affinities of the groups A aiid D, B and D, A and C.The receptor affinities and concentrations were not significantly different between the follicular and the luteal phases. From the data, no inverse correlation between the plasma insulin concentration and receptor binding was seen, i.e. the phenömenon of downiegulation pf insulin receptor concentration with hyperinsulinaemia seemed not to apply to erythrocytes.The present results suggest that insulin binding to erythrocytes is mpdulated preferably or even exclusively by an alteration of receptor affinity and that short-term chariges in insulin binding to erythroeytes are not caused by an alterätion of receptor concentration. Vergleich der Bindung von Insulin an Erythrocyten während und nach Schwangerschaft und in der Proliferationsund der Sekretionsphase des Menstruations-Cyclus

show abstract

“…Exercise has been shown to increase insulin sensitivity and attenuate insulin resistance in adult and ageing rats after exercise 130 . Likewise, insulin levels, insulin resistance and glucose tolerance may be favourably impacted by exercise in ageing and diabetic populations [131][132][133] .…”

Section: D-kefs Trail Makingmentioning

confidence: 99%

First use of creatine hydrochloride in premanifest Huntington disease

Tuckfield

2015

Medical Journal of Australia

View full text Add to dashboard Cite

Increased Insulin Receptors after Exercise in Patients with Insulin-Dependent Diabetes Mellitus

Cited by 171 publications

References 26 publications

Exercise and the metabolic syndrome

Exercise and the metabolic syndrome

Insulin Binding to Erythrocytes from Pregnant, Postpartum, Follicular and Luteal States

First use of creatine hydrochloride in premanifest Huntington disease

Contact Info

Product

Resources

About