Increased indices of free radical activity in the cerebrospinal fluid of patients with tardive dyskinesia

Manganese Superoxide Dismutase Gene Polymorphism and Schizophrenia Relation to Tardive Dyskinesia

“…This assumption is consistent with the finding that the Val/Val genotype tended to have higher total AIMS scores, although the trend did not reach the level of statistical significance. Furthermore, the finding, by several authors, of increased free radicals and decreased SOD activities in patients with TD (Lohr et al 1990;Yamada et al 1997;Tsai et al 1998) are also consistent with our assumption through following reports that the Ϫ9Ala allele may result in higher MnSOD activity. It has been reported that the Ϫ9Ala allele of MTS of the MnSOD gene has an ␣-helix structure, whereas the Ϫ9Val allele does not (ShimodaMatsubayashi et al 1996).…”

“…In a study by Pall et al (1987), CSF lipid peroxidation was increased in patients taking phenothiazine. Lohr et al (1990) reported that free radical activity was higher in patients with TD than in those without. These findings have led to therapeutic trials with ␣ -tocopherol (vitamin E), a free radical scavenging agent, in patients with TD; the anecdotal reports have been confirmed by double-blind, placebo-controlled studies with vitamin E (Egan et al 1992;Adler et al 1993;Lohr and Caligiuri 1996).…”

Nicotine Dependence, Symptoms and Oxidative Stress in Male Patients with Schizophrenia

“…For example, high levels of superoxide dismutase (SOD), a key enzyme involved in the detoxification of superoxide radicals, have consistently been found in chronic schizophrenic patients (Yao et al, 1998;Zhang et al, 2003). Moreover, high levels of lipid peroxidation products have been reported in plasma (Mahadik et al, 1998), red blood cells (Herken et al, 2001) and cerebrospinal fluid of chronic schizophrenic patients (Lohr et al, 1990). In the current study, we therefore examined SOD and two related antioxidant enzymes: glutathione peroxidase (GSH-Px) and catalase (CAT).…”

Pharmacogenetic-based risk assessment of antipsychotic-induced extrapyramidal symptoms

“…Дегенерация нейронов по причине оксидативного стресса рассматривается в качестве одного из звеньев патогенеза экстрапирамидных побочных эффектов. Этой гипотезе соответствуют данные о повышенном содержании про-дуктов перекисного окисления липидов в цереброспи-нальной жидкости пациентов с экстрапирамидными ней-ролептическими расстройствами [113,114], а также поло-жительном влиянии витамина Е на симптомы поздней дискинезии [115].…”