Increased incident hip fractures in postmenopausal women with moderate to severe pelvic organ prolapse

Pal, Lubna; Hailpern, Susan M.; Santoro, Nanette; Freeman, Ruth; Barad, David H.; Kipersztok, Simon; Barnabei, Vanessa M.; Wassertheil‐Smoller, Sylvia

doi:10.1097/gme.0b013e31821b8484

Cited by 11 publications

(9 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This inhibition may be caused by genetic factors that are associated with the original collagen metabolism, cell cycle or apoptosis, which result in POP. Furthermore, Pal et al concluded that moderate to severe POP is an independent predictor of incident spine [hazard ratio (HR), 2.61; 95% confidence interval (CI), 1.04–6.56; P=0.042] and lower arm fractures (HR, 1.87; 95% CI, 1.06–3.29; P=0.030) ( 23 ). Feola et al demonstrated that worsening pelvic supportive ability was negatively correlated with decreased collagen alignment (r 2 =−0.66) and mechanical properties (r 2 =−0.67) ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Association between pelvic organ prolapse and stress urinary incontinence with collagen

Han

Wang

et al. 2014

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

The aim of the present study was to investigate the ultrastructure and content of collagen in uterosacral ligaments and paraurethral tissues in patients with pelvic organ prolapse (POP) and stress urinary incontinence (SUI), analyzing the association between POP and collagen dysfunction. The study comprised three groups: Control, POP and POP with SUI (n=30 per group). Histological characteristics of collagen fiber were observed and the diameters were measured using light and electron microscopy to determine the Type I and Type III collagen content of the main ligament in the urethral specimens. In the POP and POP with SUI groups, observations included diffuse atrophy of smooth muscles, active fibroblast metabolism, swollen mitochondria and visible Golgi apparatus. The collagen fibril diameters in the cardinal ligaments, uterosacral ligaments and paraurethral tissues were significantly greater in the POP and POP with SUI groups compared with those in the control group (P<0.01). In addition, the expression levels of Type I and Type III collagen were significantly lower in the POP and POP with SUI groups when compared with the control group (P<0.01). In the POP with SUI group, pelvic tissues were frail, resulting in smooth muscle bundles comminuting and arranging in a disorganized pattern. Fibroblast and myoblast metabolisms were active and new microvascular cells were weak. However, the collagen fibril diameter increased. Thus, collagen and ultrastructural changes in the pelvic floor may be associated with the development of POP and SUI.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between pelvic organ prolapse and stress urinary incontinence with collagen

Han

Wang

et al. 2014

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Although a correlation between muscle strength and bone mineral density has been observed in women with early menopause [ 13 ], there is conflicting evidence on the relationship between decreased muscle strength indicated by isometric and isokinetic tests and decreasing levels of bone mineral density [ 14 , 15 , 16 ]. In this line, some studies have reported little or no association between these factors [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship of Body Composition with the Strength and Functional Capacity of People over 70 Years

Villada

González-Bernal

González‐Santos

et al. 2020

IJERPH

View full text Add to dashboard Cite

Background: Aging is a multifactorial physiological phenomenon, in which a series of changes in the body composition occur, such as a decrease in muscle mass and bone mineral density and an increase in fat mass. This study aimed to determine the relationship of muscle mass, osteoporosis, and obesity with the strength and functional capacity of non-dependent people over 70 years of age. Methods: A cross-sectional study was designed, whose study population was all people aged over 70 years, living independently and attending academic and recreational programs. Muscle strength and functional capacity of the participants were assessed by isometric exercises of lower and upper limbs and by four tests taken from the Senior Fitness Test, respectively. Bone mineral density, total mass, fat mass, total lean mass, arms lean mass, legs lean mass, and appendicular lean mass (ALM) was calculated by dual energy X-ray absorptiometry. Differences in muscle strength and functional capacity, according to the sex, muscle mass, mineral bone density and fat mass, were measured by χ2 test, independent samples Student’s t-test, analysis of covariance and a 2-factor analysis of covariance; Results: 143 subjects were included in the study group. Men and women with an adequate amount of ALM adjusted for body mass index (BMI) had a maximal dynamic biceps strength in a single repetition, a maximal isometric leg extension strength, a maximal dynamic leg extension strength in a single repetition, a maximum right hand grip strength and maximum hand grip strength (the highest). Significantly higher values were observed in the maximal isometric biceps’ strength in men with osteoporosis. Obese men had less isometric strength in the biceps and took longer to perform the chair stand test; Conclusions: Men and women with an adequate amount of ALM adjusted for BMI obtained better results in tests of muscle strength and functional capacity. However, osteoporosis and obesity are not related to these parameters.

show abstract

“…[1,10–14] A correlation has been shown between skeletal fragility and POP in postmenopausal women. [15,16]…”

Section: Introductionmentioning

confidence: 99%

Pelvic Floor Symptoms and Spinal Curvature in Women

Meyer

McArthur

Tang³

et al. 2016

Female Pelvic Med Reconstr Surg

View full text Add to dashboard Cite

Objectives To characterize the association between thoracic (T) and lumbar (L) spinal curvature and pelvic floor (PF) symptoms (pelvic organ prolapse [POP], urinary incontinence [UI], fecal incontinence [FI]). Methods Of women undergoing a bone mineral density scan from 1/2007 to 10/2010, patients who completed PF symptom questionnaires and had T and/or L spine radiographs or computerized tomography (CT) exams within 3 years of questionnaire completion were included in this study. The spine angles were measured using the Cobb angle method. The T and L curvature were categorized as hypo-kyphosis (<20°), normal thoracic kyphosis (20–40°), hyper-kyphosis (>40°), hypo-lordosis (<40°), normal lumbar lordosis (40–70°), and hyper-lordosis (>70°). The presence and type of UI were identified with the 3 Incontinence Questionnaire and FI with the Modified Manchester Questionnaire. POP was defined as a positive response to the presence of a bulge question from the PF Distress Inventory-20. Results Of 1665 eligible women, 824 and 302 (mean age 64±10 for both) had T and L spine images, respectively. No differences in PF symptoms were observed in the T or L spine groups categorized by hypo-, normal, and hyper-kyphosis/lordosis except for urgency UI being more prevalent in the hypo-lordosis group (p=0.01). However, upon further characterization using logistic regression, no association was noted between PF symptoms and T or L spine angles; no differences in the mean angles were found between women with versus without PF symptoms (p≥0.05). Conclusions The current study shows that the thoracic and lumbar spinal curvature is not associated with the presence of pelvic floor symptoms.

show abstract

Increased incident hip fractures in postmenopausal women with moderate to severe pelvic organ prolapse

Cited by 11 publications

References 31 publications

Association between pelvic organ prolapse and stress urinary incontinence with collagen

Association between pelvic organ prolapse and stress urinary incontinence with collagen

Relationship of Body Composition with the Strength and Functional Capacity of People over 70 Years

Pelvic Floor Symptoms and Spinal Curvature in Women

Contact Info

Product

Resources

About