2019
DOI: 10.1177/1093526619853179
|View full text |Cite
|
Sign up to set email alerts
|

Increased Incidence of Villitis in Placentas Exposed to Chemotherapy During Pregnancy: Is There a Correlation?

Abstract: We have identified 9 pregnant patients who were diagnosed with malignancy and initiated chemotherapy during their second trimester (cervical cancer [n = 3], leukemia [n = 3], breast cancer [n = 2], and Hodgkin’s lymphoma [n = 1]). Five of the patients’ placentas were small for gestational age (SGA). Pathologic examination revealed inflammatory changes in 4 of the placentas: 2 from the SGA placentas and 2 from non-SGA placentas. Examination revealed 3 placentas with villitis of unknown etiology (VUE) and 1 with… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2019
2019
2021
2021

Publication Types

Select...
3
2

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(2 citation statements)
references
References 18 publications
(30 reference statements)
0
2
0
Order By: Relevance
“…5 Some medications, when used in pregnancy, are associated with placental changes, including accelerated villous maturation with glucocorticoids, 6 abnormal placental shape with HIV protease inhibitors, 7 and chronic villitis or intervillositis after antineoplastic chemotherapy. 8 In addition, as described in the introduction of this manuscript, the novel mRNA vaccines induce an immune response via direct mRNA activation of TLR3, a process which has been associated in some mouse models with placental and fetal pathology.…”
Section: Reviewer #2mentioning
confidence: 98%
See 1 more Smart Citation
“…5 Some medications, when used in pregnancy, are associated with placental changes, including accelerated villous maturation with glucocorticoids, 6 abnormal placental shape with HIV protease inhibitors, 7 and chronic villitis or intervillositis after antineoplastic chemotherapy. 8 In addition, as described in the introduction of this manuscript, the novel mRNA vaccines induce an immune response via direct mRNA activation of TLR3, a process which has been associated in some mouse models with placental and fetal pathology.…”
Section: Reviewer #2mentioning
confidence: 98%
“…2009 H1N1 influenza and antineoplastic chemotherapy are associated with estimated 3-fold increases in the risk of chronic villitis. 8,10 Therefore, we felt a 3 fold increased risk was an appropriate threshold for this preliminary analysis.…”
Section: Lines 97-105 Tablementioning
confidence: 99%