Increased Incidence of Transient Left Ventricular Apical Ballooning (So-Called Takotsubo' Cardiomyopathy) After the Mid-Niigata Prefecture Earthquake

Sato, Masahito; Fujita, Shinya; Saito, Atushi; Ikeda, Yoshio; Kitazawa, Hitoshi; Takahashi, Minoru; Ishiguro, Junji; Okabe, Masaru; Nakamura, Yūichi; Nagai, Tsuneo; Watanabe, Hiroshi; Kodama, Makoto; Aizawa, Yoshifusa

doi:10.1253/circj.70.947

Cited by 110 publications

(97 citation statements)

References 23 publications

(28 reference statements)

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“…Sato, et al reported an increased incidence of Takotsubo cardiomyopathy after the 2004 mid-Niigata Prefecture Earthquake, especially in elderly women living near the epicenter. 42) For the diagnosis of Takotsubo cardiomyopathy, echocardiography, left ventriculography, or nuclear scintigraphy are performed in both the acute and stable phases. Furthermore, coronary angiography or coronary computed-tomography angiography is necessary to confirm the absence of significant coronary stenosis.…”

Section: Discussionmentioning

confidence: 99%

Occurrence of Cardiovascular Events After the 2011 Great East Japan Earthquake and Tsunami Disaster

et al. 2013

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SummaryThere are conflicting reports regarding the occurrence of cardiovascular events after a major earthquake. To understand the impact of the Great East Japan Earthquake on cardiovascular events, we retrospectively examined the clinical records prepared by emergency room physicians between 2009 and 2011 (n = 66,244), and compared the occurrence of these events between 2011 and 2009, and 2011 and 2010. There was a significant increase in the number of patients with cardiovascular events during the 3 week period after the earthquake in 2011 (n = 106) compared with that during the same period in 2009 (n = 72) or 2010 (n = 65) (P = 0.002). The number of patients with acute coronary syndrome or congestive heart failure in March 2011 was significantly increased compared with 2009 or 2010, however, there were no significant increases in 2011 in other cardiovascular events including stroke, aortic dissection, pulmonary thromboembolism, or out-of-hospital cardiac arrest compared with 2009 or 2010. These findings suggest that the incidence of cardiovascular events may have been heterogeneous after the disaster. (Int Heart J 2013; 54: 247-253)

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Section: Discussionmentioning

confidence: 99%

Occurrence of Cardiovascular Events After the 2011 Great East Japan Earthquake and Tsunami Disaster

et al. 2013

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“…7 A unique form of acute cardiac attack called "takotsubo cardiomyopathy", or "transient left ventricular apical ballooning" similarly occurs predominantly in postmenopausal women in association with emotional or physical stress. [8][9][10][11][12][13][14] Although the etiology of this syndrome is yet to be clarified, an increase of serum norepinephrine, epinephrine and neuropeptide Y levels at the onset of takotsubo cardiomyopathy compared with acute myocardial infarction suggests that the exaggerated sympathoadrenal activation triggered by stress is the primary cause of this cardiomyopathy. 9,10 Immobilization stress (IMO) in the rat provides an excellent animal model of emotional stress, which activates the hypothalamic-pituitary-adrenocortical system and the sympathoadrenal system.…”

mentioning

confidence: 99%

Chronic Estrogen Supplementation Following Ovariectomy Improves the Emotional Stress-Induced Cardiovascular Responses by Indirect Action on the Nervous System and by Direct Action on the Heart

Umemura

Ishikura

Matsuda

et al. 2007

Circ J

154

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he incidence of cardiovascular diseases is low in pre-menopausal women, whereas it is increased in post-menopausal women. Estrogen supplementation therapy prevented the increase of cardiovascular diseases in post-menopausal women, 1 while recent metaanalysis of randomized trials showed no significant merits. 2 Effects of estrogen on cardiovascular diseases were attributed principally to the modification of serum lipid concentration and coagulation pathways, while direct actions of estrogen on the cardiovascular system contributed substantially to the cardiovascular protective effects of estrogen because estrogen receptors (ER and ER ) are expressed in the blood vessels and in the heart. 3,4 Both ER and ER are also widely expressed in the central nervous system. 5 Estrogen plays crucial roles in sexual behavior, learning and memory processes, protection against ischemic insults and modulation of autonomic nervous function. 6 In fact, a reduction of estrogen levels following menopause might increase the vulnerability of women to stress while estrogen supplementation attenuates the exaggerated response to stress or to increased sympathoadrenal activity. 7 A unique form of acute cardiac attack called "takotsubo cardiomyopathy", or "transient left ventricular apical ballooning" similarly occurs predominantly in postmenopausal women in association with emotional or physical stress. [8][9][10][11][12][13][14] Although the etiology of this syndrome is yet to be clarified, an increase of serum norepinephrine, epinephrine and neuropeptide Y levels at the onset of takotsubo cardiomyopathy compared with acute myocardial infarction suggests that the exaggerated sympathoadrenal activation triggered by stress is the primary cause of this cardiomyopathy. 9,10 Immobilization stress (IMO) in the rat provides an excellent animal model of emotional stress, which activates the hypothalamic-pituitary-adrenocortical system and the sympathoadrenal system. 15 We have succeeded in developing a model of this clinical condition in rats. [16][17][18][19][20] The characteristic changes such as elevation of Circ J 2007; 71: 565 -573 (Received September 19, 2006; revised manuscript received January 9, 2007; accepted January 23, 2007 Background Takotsubo cardiomyopathy is triggered by emotional or physical stress especially in postmenopausal women. A reduction in estrogen levels following menopause might underlie the high incidence of takotsubo cardiomyopathy. Methods and ResultsThe left ventricular contraction between ovariectomized rats (OVX) and OVX with estrogen supplementation (OVX + E) while subjected to immobilization stress (IMO) was compared. The IMO in combination with general anesthesia impaired the left ventricular contraction in both OVX and OVX + E. Estrogen supplementation tended to improve the IMO-induced cardiac dysfunction and significantly attenuated the increase of blood pressure and heart rate. To understand the protective mechanism of estrogen, the expression of c-fos mRNA, a marker of cellular activation was compared. ...

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“…Inferior or lateral leads could also be involved. ST-segment is reported in approximately 30 to 50% of the TCC patients (Sharkey et al 2010;Abe et al, 2003;Akashi et al, 2005;Kurisu et al, 2002;Elesber et al, 2007;Sato et al, 2006;Tsuchihashi et al, 2001;Dib et al, 2009). Moreover, transient ST-segment isolated elevation in lead aVR has also been described in the TTC patients (Rostoff et al, 2009).…”

Section: Electrocardiogram Findingsmentioning

confidence: 98%

Tako-Tsubo Cardiomyopathy: A Recent Clinical Syndrome Mimicking an Acute Coronary Syndrome

Montassier¹,

Segard²,

Martinage³

et al. 2011

Coronary Angiography - The Need for Improvement in Medical and Interventional Therapy

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Increased Incidence of Transient Left Ventricular Apical Ballooning (So-Called Takotsubo' Cardiomyopathy) After the Mid-Niigata Prefecture Earthquake

Cited by 110 publications

References 23 publications

Occurrence of Cardiovascular Events After the 2011 Great East Japan Earthquake and Tsunami Disaster

Occurrence of Cardiovascular Events After the 2011 Great East Japan Earthquake and Tsunami Disaster

Chronic Estrogen Supplementation Following Ovariectomy Improves the Emotional Stress-Induced Cardiovascular Responses by Indirect Action on the Nervous System and by Direct Action on the Heart

Tako-Tsubo Cardiomyopathy: A Recent Clinical Syndrome Mimicking an Acute Coronary Syndrome

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