Increased incidence of psychiatric disorders in immune-mediated inflammatory disease

Marrie, Ruth Ann; Walld, Randy; Bolton, James M.; Sareen, Jitender; Walker, John R.; Patten, Scott B.; Singer, Alexander; Lix, Lisa M.; Hitchon, Carol; El‐Gabalawy, Renée; Katz, Alan; Fisk, John D.; Bernstein, Çharles N.

doi:10.1016/j.jpsychores.2017.07.015

Cited by 140 publications

(95 citation statements)

References 51 publications

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“…These findings are consistent with available epidemiological evidence indicating that the presence of one set of disorders portends increased risk for a diagnosis from the other class of disorders, though the causality and temporality of these relationships is not clearly established. [76][77][78][79][80][81][82] Positive genetic inter-correlations among these phenotypes are also consistent with recent work demonstrating that the positive correlation between BD and SZ are significantly mediated by both CNS and immunologic tissues. 83 Our local genetic correlation analyses were inadequately powered to detect loci relevant to most of the psychiatric-immune disorder pairs, including BD.…”

Section: Discussionsupporting

confidence: 89%

Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data

Tylee

Sun

Hess

et al. 2016

Preprint

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Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these altered immunological states have a shared genetic basis with those psychiatric disorders. The present study sought to use existing summary-level data from previous genome-wide association studies (GWASs) to determine if commonly varying single nucleotide polymorphisms (SNPs) are shared between psychiatric and immune-related phenotypes. We estimated heritability and examined pair-wise genetic correlations using the linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics (HESS) methods. Using LDSC, we observed significant genetic correlations between immune-related disorders and several psychiatric disorders, including anorexia nervosa, attention deficit-hyperactivity disorder, bipolar disorder, major depression, obsessive compulsive disorder, schizophrenia, smoking behavior, and Tourette syndrome. Loci significantly mediating genetic correlations were identified for schizophrenia when analytically paired with Crohn's disease, primary biliary cirrhosis, systemic lupus erythematosus, and ulcerative colitis. We report significantly correlated loci and highlight those containing genome-wide associations and candidate genes for respective disorders. We also used the LDSC method to characterize genetic correlations amongst the immune-related phenotypes. We discuss our findings in the context of relevant genetic and epidemiological literature, as well as the limitations and caveats of the study.

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Section: Discussionsupporting

confidence: 89%

Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data

Tylee

Sun

Hess

et al. 2016

Preprint

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“…We identified 10,206 individuals with incident RA, and 50,960 matched controls. Nearly three‐quarters were women, with a mean ± SD age at the index date of 53.7 ± 16.0 years (Table ) .…”

Section: Resultsmentioning

confidence: 99%

“…As described elsewhere , we applied validated case definitions for identifying depression, anxiety disorder, bipolar disorder, and schizophrenia (see , available on the Arthritis Care & Research web site at http://onlinelibrary.wiley.com/doi/10.1002/acr.23539/abstract) to identify affected individuals . To estimate the incidence of these psychiatric disorders after RA diagnosis (or the index date in matched controls), the first claim for the psychiatric disorder had to occur after the index date, and had to be preceded by a 5‐year period with no claims for that psychiatric disorder.…”

Section: Methodsmentioning

confidence: 99%

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis

Marrie

Hitchon

Walld

et al. 2018

Arthritis Care & Research

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ObjectiveWe estimated the incidence and prevalence of depression, anxiety disorder, bipolar disorder, and schizophrenia in a population‐based cohort with rheumatoid arthritis (RA) as compared to an age‐, sex‐, and geographically matched cohort without RA.MethodsUsing population‐based administrative health data from Manitoba, Canada, we identified persons with incident RA between 1989 and 2012, and a cohort from the general population matched 5:1 on year of birth, sex, and region of residence. We applied validated algorithms for depression, anxiety disorder, bipolar disorder, and schizophrenia to determine the annual incidence of these conditions after the diagnosis of RA, and their lifetime and annual period prevalence. We compared findings between cohorts using negative binomial regression models.ResultsWe identified 10,206 incident cases of RA and 50,960 matched individuals. After adjustment for age, sex, socioeconomic status, region of residence, number of physician visits, and year, the incidence of depression was higher in the RA cohort over the study period (incidence rate ratio [IRR] 1.46 [95% confidence interval (95% CI) 1.35–1.58]), as was the incidence of anxiety disorder (IRR 1.24 [95% CI 1.15–1.34]) and bipolar disorder (IRR 1.21 [95% CI 1.00–1.47]). The incidence of schizophrenia did not differ between groups (IRR 0.96 [95% CI 0.61–1.50]). Incidence rates of psychiatric disorders declined minimally over time. The lifetime and annual period prevalence of depression and anxiety disorder were also higher in the RA than in the matched cohort over the study period.ConclusionThe incidence and prevalence of depression, anxiety disorder, and bipolar disorder are elevated in the RA population as compared to a matched population.

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“…Chronic disorders, such as CD not only affect physical health, but also mental health, thereby increasing the chances of acquiring comorbid mood disorders including depression or anxiety (5)(6)(7). In fact, it has also been shown that persons with CD are more likely to have depression or anxiety antedating CD diagnosis by years, suggesting possible shared risk factors for both chronic mental health disorders and CD (8,9). Physiologically, as a threat to homeostasis, there are a number of mechanisms by which stress may impact the gastrointestinal tract (10).…”

Section: Introductionmentioning

confidence: 99%

Brain Resting-State Network Alterations Associated With Crohn's Disease

Kornelsen

Wilson

Labus³

et al. 2020

Front. Neurol.

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Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) and 21 healthy controls (HC). Voxel-based morphometry (VBM) analysis was performed to contrast CD and HC structural images. Region of interest (ROI) analyses were run to assess FC for resting-state network nodes. Independent component analysis (ICA) identified whole brain differences in FC associated with resting-state networks. Though no structural differences were found, ROI analyses showed increased FC between the frontoparietal (FP) network and salience network (SN), and decreased FC between nodes of the default mode network (DMN). ICA results revealed changes involving cerebellar (CER), visual (VIS), and SN components. Differences in FC associated with sex were observed for both ROI analysis and ICA. Taken together, these changes are consistent with an influence of CD on the brain and serve to direct future research hypotheses.

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Increased incidence of psychiatric disorders in immune-mediated inflammatory disease

Cited by 140 publications

References 51 publications

Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data

Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis

Brain Resting-State Network Alterations Associated With Crohn's Disease

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