HighlightsPFC-amygdala FC is altered in GAD, indicating top-down processing deficits.GAD had reduced activity for emotion regulation and working memory in the culmen.Salience, default, and central executive nodes have altered structure and function.

Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) and 21 healthy controls (HC). Voxel-based morphometry (VBM) analysis was performed to contrast CD and HC structural images. Region of interest (ROI) analyses were run to assess FC for resting-state network nodes. Independent component analysis (ICA) identified whole brain differences in FC associated with resting-state networks. Though no structural differences were found, ROI analyses showed increased FC between the frontoparietal (FP) network and salience network (SN), and decreased FC between nodes of the default mode network (DMN). ICA results revealed changes involving cerebellar (CER), visual (VIS), and SN components. Differences in FC associated with sex were observed for both ROI analysis and ICA. Taken together, these changes are consistent with an influence of CD on the brain and serve to direct future research hypotheses.

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University athletes are at high risk for both substance use and mental health problems. This study examined associations between substance use, mental health symptoms, and the resting state functional connectivity (rsFC) of key neural regions involved in self-monitoring and emotional regulation in a sample of female varsity athletes. 31 female university athletes completed measures of substance use, mental health symptoms, and underwent functional MRI scans during the pre-season. Athletes who were substance users had higher symptoms of depression than non-users (p = 0.04; Hedge’s g = 0.81). RsFC differences were observed between users and non-users in orbital frontal cortex (OFC) and bilateral hippocampal seeds, and negative associations between depression symptoms and rsFC in the left hippocampus and posterior cingulate cortex were observed in cannabis users. In female athletes, substance use is associated with greater self-reported depression symptoms and altered rsFC in self-monitoring and emotional regulation regions of the brain.

Emotional stimuli modulate activity in brain areas related to attention, perception, and movement. Similar increases in neural activity have been detected in the spinal cord, suggesting that this understudied component of the central nervous system is an important part of our emotional responses. To date, previous studies of emotion-dependent spinal cord activity have utilized long presentations of complex emotional scenes. The current study differs from this research by (1) examining whether emotional faces will lead to enhanced spinal cord activity and (2) testing whether these stimuli require conscious perception to influence neural responses. Fifteen healthy undergraduate participants completed six spinal functional magnetic resonance imaging (fMRI) runs in which three one-minute blocks of fearful, angry, or neutral faces were interleaved with 40-s rest periods. In half of the runs, the faces were clearly visible while in the other half, the faces were displayed for only 17 ms. Spinal fMRI consisted of half-Fourier acquisition single-shot turbo spin-echo (HASTE) sequences targeting the cervical spinal cord. The results indicated that consciously perceived faces expressing anger elicited significantly more activity than fearful or neutral faces in ventral (motoric) regions of the cervical spinal cord. When stimuli were presented below the threshold of conscious awareness, neutral faces elicited significantly more activity than angry or fearful faces. Together, these data suggest that the emotional modulation of spinal cord activity is most impactful when the stimuli are consciously perceived and imply a potential threat toward the observer.

University athletes are exposed to numerous impacts to the body and head, though the potential cumulative effects of such hits remain elusive. This study examined resting-state functional connectivity (rsFC) of brain networks in female varsity athletes over the course of a season. Nineteen female university athletes involved in collision ( N = 12) and contact ( N = 7) sports underwent functional magnetic resonance imaging scans at both pre- and post-season. A group-level independent component analysis (ICA) was used to investigate differences in rsFC over the course of a season and differences between contact and collision sport athletes. Decreased rsFC was observed over the course of the season between the default mode network (DMN) and regions in the frontal, parietal, and occipital lobe ( p false discovery rate, ≤0.05) driven by differences in the contact group. There was also a main effect of group in the dorsal attention network (DAN) driven by differences between contact and collision groups at pre-season. Differences identified over the course of a season of play indicate largely decreased rsFC within the DMN, and level of contact was associated with differences in rsFC of the DAN. The association between exposure to repetitive head impacts (RHIs) and observed changes in network rsFC supplements the growing literature suggesting that even non-concussed athletes may be at risk for changes in brain functioning. However, the complexity of examining the direct effects of RHIs highlights the need to consider multiple factors, including mental health and sport-specific training and expertise, that may potentially be associated with neural changes.

Objective The effects of participation in contact sports on brain functioning is a growing area of concern in the athlete population. This pilot study examined differences in resting-state functional connectivity (rsFC) associated with level of contact in female varsity student athletes. Method Resting-state functional magnetic resonance imaging (fMRI) scans were collected from 29 female university athletes. Level of contact was characterized by active participation in collision sports (n = 13) and contact sports (n = 16). Athletes completed baseline testing including self-reported psychological measures. RsFC was compared between groups using Independent Component Analysis (ICA) within the default mode (DMN), frontoparietal (FPN), dorsal attention (DAN), salience (SN), and sensorimotor (SMN) networks. Results Collision sport athletes reported younger age at first sport (M = 4.7, SD = 1.2) and fewer past concussions (Md = 0, Range = 0–3) compared to contact sport athletes (M = 7.5, SD = 3.4; Md = 7.5, Range = 0–6; ps < .05). Collision sport athletes also reported fewer symptoms of depression on the Patient Health Questionnaire-9 (p = 0.03). Collision sport athletes had decreased rsFC between the SMN and the left inferior frontal gyrus (T = −5.6, pFDR = 0.008) compared to the contact sport athletes. This difference in rsFC was not associated with age at first sport or prior concussion history. Conclusions Consistent with prior studies of varsity athletes, altered patterns of rsFC were observed in areas supporting somatomotor function in female athletes with suspected greater contact exposure. Further research is necessary to examine whether these neural changes are attributable to greater exposure to sub-concussive hits or other factors, such as differences in visuomotor abilities.

[Outstanding Trainee Award Winner] Purpose Assessment of postural balance in varsity athletes is essential to managing sport-related concussion. The current study characterizes the relationship between subjective and objective measures of balance in varsity athletes. Methods A total of 208 varsity athletes across 12 sports participated in pre-season testing from June 2019 to January 2020 (no history of concussion= 117; 1+ past concussion= 91). Measures included the Sport Concussion Assessment Tool (SCAT-5) and the AccuGait force plate. Relationships between objective and subjective balance measures were assessed using correlations, parametric, and non-parametric tests. Results Of the total sample, 9.6% (n=20) endorsed subjective balance issues and 5.3% (n=11) reported subjective dizziness. Those with a history of concussion, endorsed greater total number of symptoms at baseline (M=2.95, SD=4.03) than those without (M=1.90, SD=3.07; p=.04; Cohen’s d=.30). However, there were no differences on subjective or objective balance measures (i.e., total balance error on the MBESS or force plate measures; ps>0.05) between athletes with and without a history of concussion. For those with no history of concussion, total balance errors from the Modified Balance Error Scoring system were significantly associated with force plate metrics in the eyes closed condition (ps<0.05) but not the eyes open condition. These associations were not observed in athletes with history of concussion (ps>0.05). Similarly, no associations were found between subjective balance issues and objective balance metrics. Conclusions Overall, findings suggest poor alignment between subjective and objective balance measures in varsity athletes, regardless of concussion history. Associations were observed across the objective balance measures in those with no history of injury, but not in athletes with a history of concussion.