Increased incidence of pancreatic neoplasia in pernicious anemia

Borch, Kurt; Kullman, Eric; Hallhagen, Stefan; Ledin, Torbjörn; Ihse, Ingemar

doi:10.1007/bf01655502

Cited by 47 publications

(21 citation statements)

References 29 publications

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“…54 Another Swedish study followed 361 patients with pernicious anaemia for 7 years and reported a 0.6% annual incidence of gastric cancer. 55 Other studies also reported that the gastric cancer risk in patients with pernicious anaemia was three-to five-fold increased. [56][57][58][59][60][61][62] Several prospective studies focused on the development of gastric cancer in patients with intestinal metaplasia type III or more severe dysplasia.…”

Section: Atrophy Metaplasia and Gastric Cancer: Prospective Studiesmentioning

confidence: 99%

Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer

Kuipers

1998

Aliment Pharmacol Ther

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Section: Atrophy Metaplasia and Gastric Cancer: Prospective Studiesmentioning

confidence: 99%

Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer

Kuipers

1998

Aliment Pharmacol Ther

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“…About 30% of cases are attributable to smoking. 1,4 An increased frequency of pancreatic cancer has been suggested among individuals with a long-standing history of diabetes, 5,6 chronic pancreatitis, 7,8 pernicious anemia 9 and inheritable syndromes such as familial adenomatous polyposis. 10,11 An elevated risk of pancreatic cancer has also been seen in families with a history of breast cancer and BRCA2 mutations.…”

mentioning

confidence: 99%

Dietary patterns and risk of pancreatic cancer

Nkondjock

Krewski

Johnson

et al. 2005

Intl Journal of Cancer

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To investigate associations between broad dietary patterns and pancreatic cancer risk, we conducted a case-control study of 585 histologically confirmed pancreatic cancer cases and 4,779 population-based controls in 8 Canadian provinces between 1994 and 1997. Dietary intake was assessed using a FFQ. Major dietary patterns were identified by factor analysis. Unconditional logistic regression was used to describe associations between dietary pattern scores and risk of pancreatic cancer. Three dietary patterns were identified: Western, characterized by high intake of processed meats, sweets and desserts, refined grains and potatoes; fruits and vegetables, characterized by high intake of fresh fruits and cruciferous vegetables; drinker, characterized by high consumption of liquor, wine and beer. After adjustment for age, BMI, smoking, physical activity, province, educational attainment and total energy intake, the fruits and vegetables pattern was associated with a 49% reduction in pancreatic risk among men (OR ‫؍‬ 0.51, 95% CI 0. Because of its incidence and poor prognosis, pancreatic cancer is one of the most important human malignancies. Approximately 216,300 new cases occur worldwide each year. 1 In Canada in 2004, it is the fourth leading cause of cancer-related death in both men and women. 2 Survival is extremely low, with a 5-year rate of Ͻ5% 3 and a case-fatality ratio of 0.99. 2 Few risk factors for pancreatic cancer have been consistently identified. About 30% of cases are attributable to smoking. 1,4 An increased frequency of pancreatic cancer has been suggested among individuals with a long-standing history of diabetes, 5,6 chronic pancreatitis, 7,8 pernicious anemia 9 and inheritable syndromes such as familial adenomatous polyposis. 10,11 An elevated risk of pancreatic cancer has also been seen in families with a history of breast cancer and BRCA2 mutations. 12,13 It has been estimated that 30 -50% of pancreatic cancers may be due to dietary factors, 14 though for most dietary components the overall evidence is equivocal. A number of investigators have recorded a heightened risk in relation to excessive intake of fat, 15 grilled and salted/smoked red meats, 16,17 dairy products 18 and cholesterol, 19,20 though some of these associations were not confirmed in a large prospective cohort of women. 21 In contrast, pancreatic cancer risk has been found to decrease with increased consumption of fresh fruits and vegetables 20,22 as well as foods containing no preservatives or additives 19,20 and with increased carbohydrate and energy intake. 23 However, no studies to date have examined broader food consumption, which provides a more comprehensive representation of dietary intake involving a large number of dietary components working together. The present investigation was undertaken to explore the possible role of major dietary patterns in the etiology of pancreatic cancer within the Canadian NECSS. Material and methods Study populationThe NECSS is a multisite, population-based, case-control study involving ...

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“…Several previous studies have documented an increased incidence of stomach cancer in patients with pernicious anaemia (PA) (Blackburn et al, 1968;Elsborg and Mosbech, 1979;Borch et al, 1988;Brinton et al, 1989;Hsing et al, 1993). An increase in the risk for other upper gastrointestinal cancers such as buccal cavity and pharynx (Brinton et al, 1989;Hsing et al, 1993) and oesophagus (Hsing et al, 1993) has also been reported, as well as increases for other digestive organ cancers [liver, biliary tract and pancreas (Hsing et al, 1993)], though these cancers have been investigated less extensively among PA patients than stomach cancer.…”

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confidence: 99%

Pernicious anaemia and cancer risk in Denmark

Mellemkjær

Gridley²,

Møller³

et al. 1996

Br J Cancer

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Summary A cohort of 5072 patients with pernicious anaemia was identified in the Danish Hospital Discharge Register from 1977 to 1989 and, through linkage to the Danish Cancer Registry, the occurrence of cancer in the cohort was determined up to 1991. Observed numbers of cancer cases during 1-15 years of follow-up were compared with expected numbers based on national incidence rates. Besides the well-established increased risk for stomach cancer, the analysis also revealed a 2-fold increase in the relative risk for cancer of the buccal cavity and pharynx among pernicious anaemia patients in accordance with previous studies; previously reported elevated risks for other digestive tract cancers were not confirmed. There was a non-significantly increased risk for lymphatic and haematological malignancy but the risk tended to disappear after 5 years of follow-up, indicating a possible selection bias. Decreased risks for cervical cancer and non-melanoma skin cancer were also seen.

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Increased incidence of pancreatic neoplasia in pernicious anemia

Cited by 47 publications

References 29 publications

Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer

Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer

Dietary patterns and risk of pancreatic cancer

Pernicious anaemia and cancer risk in Denmark

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