Increased in vitro Tuberculin and Endotoxin Leukocytolysis Following Skin Tests with Homologous and Heterologous Substances

Studies of the Mechanism whereby Adjuvant Disease is Suppressed in Rats Pretreated with Mycobacteria

“…The specific unresponsiveness produced in adult animals by single or repeated systemic doses of protein antigen has been shown by suitable transfer experiments to depend on a specific inability of lymphoid cells to respond to antigenic challenge (22). The apparent non-specificity of the inhibitory effect under consideration here, i. e. the effectiveness of Nocardia and of lipopolysaccharide antigens from Gram-negative organisms as well as of tubercle bacilli, may be illusory since these materials contain cross-reacting antigens (23,24). On the other hand, sensitization with a competing antigen such as ovalbumin or bovine serum albumin has been shown to inhibit ad juvant disease largely or completely (25,26).…”