Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation

László, Valéria; Rothe, Gregor; Hegyesi, Hargita; Szeberényi, Júlia; Orsoó, E.; Schmitz, Gerd; Falus, András

doi:10.1007/pl00000266

Cited by 40 publications

(11 citation statements)

References 33 publications

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“…On the other hand, histidine, the major component amino acid of filaggrin, is a substrate of mast cell histidine decarboxylase (HDC) producing histamine. HDC has been reported to be induced by various stimuli, not only in mast cells and basophils, but also in neutrophils, T lymphocytes, macrophages and keratinocytes (22, 23). As HDC has been observed to be increased in CIU skin (24), greater histidine release may result in the more histamine production in wheals from CIU patients.…”

Section: Discussionmentioning

confidence: 99%

Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria

Shin

Park

et al. 2014

Annals of Allergy, Asthma & Immunology

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Section: Discussionmentioning

confidence: 99%

Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria

Shin

Park

et al. 2014

Annals of Allergy, Asthma & Immunology

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“…Among these, mast cell histamine is an axial player in stimulating the development of allergic-related inflammatory diseases by regulating the maturation and activation of leukocytes and directing their migration to target sites where they cause chronic inflammation ( 5 – 8 ). Histamine also exerts a various other immune regulatory functions by modulating the functions of monocytes ( 9 ), T cells ( 10 , 11 ), macrophages ( 12 ), neutrophils ( 13 ), eosinophils ( 14 ), B cells, and dendritic cells ( 15 ). The biological impact of histamine follow their interaction with four types histamine receptors, H1R, H2R, H3R, and H4R, all of which belong to the G protein coupled receptor family ( 8 , 16 – 20 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets

et al. 2018

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Histamine and its receptors (H1R–H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in the body. H1R are expressed in many cells, including mast cells, and are involved in Type 1 hypersensitivity reactions. H2R are involved in Th1 lymphocyte cytokine production. H3R are mainly involved in blood–brain barrier function. H4R are highly expressed on mast cells where their stimulation exacerbates histamine and cytokine generation. Both H1R and H4R have important roles in the progression and modulation of histamine-mediated allergic diseases. Antihistamines that target H1R alone are not entirely effective in the treatment of acute pruritus, atopic dermatitis, allergic asthma, and other allergic diseases. However, antagonists that target H4R have shown promising effects in preclinical and clinical studies in the treatment of several allergic diseases. In the present review, we examine the accumulating evidence suggesting novel therapeutic approaches that explore both H1R and H4R as therapeutic targets for histamine-mediated allergic diseases.

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“…7,8 Our group previously reported that the expression of HDC mRNA is accelerated during the progression of atherosclerosis in the human aorta and that HDC localization is identified in the Mɸ-derived foam cells and lymphocytes. 9 Additionally, in vitro experiments have shown that, when human peripheral monocytes are differentiated into Mɸs, the expression of HDC is elevated, 10 suggesting that histamine is released by the Mɸs abundantly observed in atheromatous aortic plaque or arteriosclerotic stenosis of the carotid artery. 3,5,11 Therefore, we hypothesized that histamine played a crucial role in the pathogenesis of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Critical in vivo roles of histamine and histamine receptor signaling in animal models of metabolic syndrome

Yamada

Tanimoto

Sasaguri

2016

Pathology International

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Histamine, a classic low-molecular-weight amine, is synthesized from L-histidine by histidine decarboxylase (HDC), and histamine-specific receptors (HRs) are essential for its actions. Our serial in vivo studies have uniquely reported that expression of histamine/HRs is variably identified in atherosclerotic lesions, and that HDC-gene knockout mice without histamine/HRs signaling show a marked reduction of atherosclerotic progression. These data have convinced us that histamine plays a pivotal role in the pathogenesis of atherosclerosis. Among four subclasses of HRs, the expression profile of the main receptors (H1/2R) has been shown to be switched from H2R to H1R during monocyte to macrophage differentiation, and H1R is also predominant in smooth muscle and endothelial cells of atheromatous plaque. Using various animal models of H1/2R-gene knockout mice, H1R and H2R were found to reciprocally but critically regulate not only hypercholesterolemia-induced atherosclerosis and injury-induced arteriosclerosis, but also hyperlipidemia-induced nonalcoholic fatty liver disease (NAFLD). Metabolic syndrome manifests obesity, dyslipidemia, insulin resistance, atherosclerosis, and/or NAFLD, i.e. the dysregulation of lipid/bile acid/glucose metabolism. Therefore, although its etiology is complicated and multifactorial, histamine/HRs signaling has a close relationship with the development of metabolic syndrome. We herein review diverse, key in vivo roles of histamine/HR signaling in the pathogenesis of metabolic syndrome.

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Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation

Abstract: These data support the elevation of HDC expression during human monocytic differentiation and the possibility that monocyte-derived histamine is partially involved in regulation of M-CSF induced in vitro human monocyte/macrophage phagocytic differentiation.

Cited by 40 publications

References 33 publications

Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria

Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets

Critical in vivo roles of histamine and histamine receptor signaling in animal models of metabolic syndrome

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