Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria

Ye, Young-Min; Shin, Yoo Seob; Park, Hae‐Sim; Leung, Donald Y.M.

doi:10.1016/j.anai.2014.03.016

Cited by 16 publications

(20 citation statements)

References 32 publications

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“…In the present study and others, a significantly lower pH in CSU skin than in AD and NC skin was observed 8 . Meanwhile, the photoisomerisation of trans- to cis- UCA has been shown to be more efficient at a lower skin pH (3 to 5.5) than at a higher skin pH 21 , explaining the increased cis- to- trans- UCA ratio in CSU skin.…”

Section: Discussionsupporting

confidence: 68%

Increased cis-to-trans urocanic acid ratio in the skin of chronic spontaneous urticaria patients

Pham

Lim

Joo

et al. 2017

Sci Rep

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Increased filaggrin expression was found to be correlated with severity scores in chronic spontaneous urticaria (CSU); however, the role of filaggrin breakdown products (FBPs) in CSU has not been studied. We collected stratum corneum (SC) specimens from the volar forearms of 10 CSU patients, 10 AD patients, and 10 healthy normal controls (NCs) and measured contents of FBPs (pyrrolidone carboxylic acid [PCA] and urocanic acid [UCA]) using UPLC-MS/MS, transepidermal water loss (TEWL) and epidermal pH. Compared to NCs, cis-UCA level was increased in CSU lesions (P < 0.05) and decreased in AD lesions (P < 0.01). The cis-to-trans-UCA ratio in SC specimens from CSU patients was significantly greater than those from AD and NC subjects. AD lesions had lower FBP and PCA contents compared to NC skin (both P < 0.001), and higher TEWL and pH compared to CSU lesions. Moreover, cis-UCA, but not trans-UCA, enhanced the IgE-mediated basophil activation, as well as IgE- and calcium-mediated degranulation of LAD-2 cells, in a dose-dependent manner. These findings suggest that increased cis-to-trans UCA ratio in the epidermis is a distinct feature of CSU, which could enhance mast cell degranulation. Modulation of cis-UCA may be a potential target for skin diseases associated with IgE-mediated mast cell degranulation.

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Section: Discussionsupporting

confidence: 68%

Increased cis-to-trans urocanic acid ratio in the skin of chronic spontaneous urticaria patients

Pham

Lim

Joo

et al. 2017

Sci Rep

Self Cite

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“…In a recent study conducted in 16 Korean patients with CSU/CIU, an increased expression of the gene that codifies the filaggrin was observed (by qPCR and immunohistochemistry). Additionally, a potential relationship between filaggrin gene expression and urticaria activity was detected . The authors found an increased amount of cis‐urocanic acid (filaggrin metabolite) in the CSU epidermis and speculate about its pathogenic potential role.…”

Section: Discussionmentioning

confidence: 94%

Transcriptome analysis of severely active chronic spontaneous urticaria shows an overall immunological skin involvement

Giménez‐Arnau

Curto‐Barredo

Nonell

et al. 2017

Allergy

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“…Another interesting function of IL‐31 is its involvement in filaggrin expression . Atopic dermatitis is mostly characterized by filaggrin deficiency, whereas in chronic urticaria, filaggrin expression has been reported to be enhanced . As IL‐31 serum levels are higher in atopic dermatitis compared to CsU , it may be possible that regulation of filaggrin expression is dependent on IL‐31 serum levels.…”

Section: Discussionmentioning

confidence: 99%

Human basophils are a source of ‐ and are differentially activated by ‐ IL‐31

Raap

Gehring

Kleiner

et al. 2017

Clin Experimental Allergy

104

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SummaryBackground Basophils are important effector cells involved in the pathogenesis of inflammatory skin diseases including chronic urticaria which is associated by increased IL-31 serum levels. So far the effects of IL-31 on human basophils are unknown. Objective To analyse the functional role of IL-31 in basophil biology. Methods IL-31 expression was evaluated in skin samples derived from chronic spontaneous urticaria patients. Oncostatin M receptor (OSMR), IL-31 receptor A (RA) and IL-31 protein expressions were analysed on human basophils from healthy donors. Basophil responses to IL-31 were assessed for chemotaxis, externalization of CD63 and CD203c as well as the release of histamine, IL-4 and IL-13. Results IL-31RA and OSMR were expressed on human basophils. IL-31 was strongly expressed in the skin of patients with chronic spontaneous urticaria and was released from isolated basophils following either anti-IgE, IL-3 or fMLP stimulation. IL-31 induced chemotaxis and the release of IL-4 and IL-13 which was specifically inhibited by anti-IL-31RA and anti-OSMR. Conversely, IL-31 had no effect on CD63 and CD203c externalization or histamine release. Conclusions and Clinical Relevance Human basophils are a source of -and are activated by -IL-31 with the release of pro-inflammatory cytokines and the induction of chemotaxis indicating an important novel function of IL-31 in basophil biology.

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Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria

Cited by 16 publications

References 32 publications

Increased cis-to-trans urocanic acid ratio in the skin of chronic spontaneous urticaria patients

Increased cis-to-trans urocanic acid ratio in the skin of chronic spontaneous urticaria patients

Transcriptome analysis of severely active chronic spontaneous urticaria shows an overall immunological skin involvement

Human basophils are a source of ‐ and are differentially activated by ‐ IL‐31

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