Increased heterogeneity in expression of genes associated with cancer progression and drug resistance

Bose, Anwesha; Datta, Subhasis; Mandal, Rakesh; Ray, Upasana; Dhar, Riddhiman

doi:10.1016/j.tranon.2024.101879

Cited by 3 publications

(1 citation statement)

References 156 publications

(185 reference statements)

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“…The EMP‐induced phenotypic heterogeneity of tumor is tightly associated with therapeutic resistance. 209 Recent research using RNA sequence analysis indicates that therapy sensitive cells exhibit MET, while therapy resistant cells exhibit EMT. 13 Increasing evidence suggests that both EMT‐TFs such as Snail and Twist as well as EMT‐related signaling pathways including TGF‐β, Wnt, and Notch are correlated with the therapeutic resistance.…”

Section: Emp and Therapeutic Resistancementioning

confidence: 99%

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

Wang,

Xue,

Pang

et al. 2024

MedComm

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Currently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all of which are tightly related to the phenotypic plasticity especially epithelial–mesenchymal plasticity (EMP). Tumor cells with EMP are manifest in three states as epithelial–mesenchymal transition (EMT), partial EMT, and mesenchymal–epithelial transition, which orchestrate the phenotypic switch and heterogeneity of tumor cells via transcriptional regulation and a series of signaling pathways, including transforming growth factor‐β, Wnt/β‐catenin, and Notch. However, due to the complicated nature of EMP, the diverse process of EMP is still not fully understood. In this review, we systematically conclude the biological background, regulating mechanisms of EMP as well as the role of EMP in therapy response. We also summarize a range of small molecule inhibitors, immune‐related therapeutic approaches, and combination therapies that have been developed to target EMP for the outstanding role of EMP‐driven tumor deterioration. Additionally, we explore the potential technique for EMP‐based tumor mechanistic investigation and therapeutic research, which may burst vigorous prospects. Overall, we elucidate the multifaceted aspects of EMP in tumor progression and suggest a promising direction of cancer treatment based on targeting EMP.

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Section: Emp and Therapeutic Resistancementioning

confidence: 99%

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

Wang,

Xue,

Pang

et al. 2024

MedComm

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Living in a noisy world—origins of gene expression noise and its impact on cellular decision‐making

Pal,

Dhar

2024

FEBS Letters

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The expression level of a gene can vary between genetically identical cells under the same environmental condition—a phenomenon referred to as gene expression noise. Several studies have now elucidated a central role of transcription factors in the generation of expression noise. Transcription factors, as the key components of gene regulatory networks, drive many important cellular decisions in response to cellular and environmental signals. Therefore, a very relevant question is how expression noise impacts gene regulation and influences cellular decision‐making. In this Review, we summarize the current understanding of the molecular origins of expression noise, highlighting the role of transcription factors in this process, and discuss the ways in which noise can influence cellular decision‐making. As advances in single‐cell technologies open new avenues for studying expression noise as well as gene regulatory circuits, a better understanding of the influence of noise on cellular decisions will have important implications for many biological processes.

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Mitochondrial signaling pathways and their role in cancer drug resistance

Sharma,

Virmani,

Kumar

et al. 2024

Cellular Signalling

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Increased heterogeneity in expression of genes associated with cancer progression and drug resistance

Cited by 3 publications

References 156 publications

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

Living in a noisy world—origins of gene expression noise and its impact on cellular decision‐making

Mitochondrial signaling pathways and their role in cancer drug resistance

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