Increased H2O2 level in exhaled breath condensate in primary breast cancer patients

Abstract

This is the first study to demonstrate increased H(2)O(2) in exhaled breath condensate in patients with localized breast malignancy and its relation with clinical severity.

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

“…98 Similarly, human breast and lung cancer patients can be positively identified by examining their exhaled breath for the presence of hydrogen peroxide. [99][100][101] In accordance with their idea that hydrogen peroxide may be produced by the tumor stroma, the exhaled breath of patients with idiopathic pulmonary fibrosis also shows increased levels of hydrogen peroxide. 102 Finally, tumor cell production of hydrogen peroxide drives NFκB-activation in adjacent normal cells in culture 6 and during metastasis, 103 directly implicating the use of antioxidants, NFκB-inhibitors and anti-inflammatory agents, in the treatment of aggressive human cancers.…”

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

“…126,127 can be distinguished from normal controls, based on the detection of hydrogen peroxide in their exhaled breath. [110][111][112] Consistent with the idea that hydrogen peroxide may also originate from the tumor stroma, patients with interstitial pulmonary fibrosis show increased levels of hydrogen peroxide in their exhaled breath. 113 Also, patients with pulmonary fibrosis show a loss of stromal Cav-1 expression, providing another mechanistic link.…”

Induced Sputum, Exhaled NO, and Breath Condensate in Occupational Medicine

“…Elevated H 2 O 2 levels have been documented in different populations of patients with asthma, 37,38 pulmonary fibrosis, 39 primary lung cancer, 40 and asbestosis 41 compared with control subjects. In asthma, a negative correlation between H 2 O 2 , forced expiratory volume in 1 second, and peak expiratory flow rate have been reported, 42 as well as a positive correlation between expired H 2 O 2 , sputum eosinophils, and airway hyperresponsiveness.…”