Increased growth of RSV-induced tumors in chickens partially tolerant to MHC alloantigens

Abstract

Chickens with B2B2 MHC genotypes were made partically tolerant to B5 MHC cell-surface antigens and the fate of their Rous-sarcoma-virus (RSV)-induced tumors was determined. B2B2 chickens partially tolerant to viable or lysed white blood cells (WBC) or viable red blood cells (RBC) from B5B5 chickens had a significantly higher incidence of tumor progression than untreated, PBS-treated, or B2B2 chickens inoculated with WBC from other B2B2 chickens. The criteria for tolerance were absence of antibody titer to the cell type inoculated and acceptance of allografts from B5B5 donors by B2B2 chickens. Graft-vs-host reactions occurred only in B2B2 chickens inoculated with viable WBC from B5B5 chickens. It appears that B2B2 chickens partially tolerant to B5 antigens failed to mount a successful immune response to RSV-induced tumors partly because of a B5 MHC antigen(s) cross-reacted with a tumor associated antigen(s) thereby severely limiting B2B2 host recognition of the tumor as foreign. Since WBC and RBC cell-surface antigens appear to contribute similarly to the effect, the B-F- region of the MHC may be involved.

Genetics of the response to Rous sarcoma virus‐induced tumours in chickens*

“…Genetic recombination provides a method for studying the detailed genetic structure of a chromosome. This has been confirmed by Plachy.& Benda (1981) using the Prague lines, and by Heinzelmann et al (1981aHeinzelmann et al ( , 1981b. These were R1 (BE4-G23), R2 and R3 (Bn-Ga) and R5 (BP-l-G19).…”

“…Clearly more research is necessary to clarify the mechanism of host-tumour interaction. Cross-reaction of B, MHC antigens with tumour-associated antigen(s) may have limited BVB2 recognition of the tumour as foreign and led to greater tumour growth and death (Heinzelmann et al, 1981a(Heinzelmann et al, , 1981b. Although the anti-lymphocyte serum used was not specific for T-lymphocytes, according to the authors it did have anti-T, and likely anti-B, activity.…”

Chicken Major Histocompatibility Complex and Disease

“…The mechanism of action of these genes is not yet known, but it has been shown that MHC controlled tumour rejection operates at the level of recognition of viral or cellular determinants different from those which define classical viral groups or subgroup specificities [25]. The inability of the host to recognize RSV-induced tumours as foreign, due to cross-reactivity between tumour-and allo-antigens has been shown [44]; by tolerizing B2 chickens to B5 alloantigens, the reactivity to RSV-induPed tumours was diminished [45].…”

Complementation of Major Histocompatibility Haplotypes in Regression of Rous Sarcoma Virus-Induced Tumors in Noninbred Chickens ,

“…Several studies using various tumor systems in rats and mice have demonstrated such cross-reactivity (Bear et al, 1977;Parmiani et al, 1979;Russell et al, 1979;Paciucci et al, 1980). Heinzelmann et al, (1981) investigated the role of tolerance to blood alloantigens on Rous sarcoma development in chickens. The anti-tumor response of B 2 B 2 (high responder) White Leghorns made partially tolerant to blood alloantigens from B s B 5 (low responder) animals was significantly smaller than that of B 2 B 2 controls.…”