Genetics of the response to Rous sarcoma virus‐induced tumours in chickens*

Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for resistance to fowl cholera by challenge with Pasteurella multocida strain X73. Control of the response at high doses was associated in a preliminary study with Ir-GAT and response to RSV tumors. Genetic control of resistance to low doses of P. multocida was demonstrated via sublines and F2 segregants to be linked with genes of the B-Gregion. Thus, genetic control of resistance to fowl cholera in chickens after exposure to Pasteurella multocida was shown to be linked to the major histocompatibility B complex, in this first demonstration of MHC-linked resistance to bacterial disease challenge.

show abstract

Genetics of the response to Rous sarcoma virus‐induced tumours in chickens*

Cited by 12 publications

References 71 publications

Biology of Avian Retroviruses

Biology of Avian Retroviruses

Regression of Neoplasms in Vertebrates

Genetic resistance to fowl cholera is linked to the major histocompatibility complex

Contact Info

Product

Resources

About