Increased glutathione levels contribute to the beneficial effects of hydrogen sulfide and inducible nitric oxide inhibition in allergic lung inflammation

Campos, Daiana; Ravagnani, Felipe Gustavo; Gurgueira, Sonia A.; Vercesi, Anı́bal E.; Teixeira, Simone Aparecida; Costa, Soraia K.P.; Muscará, Marcelo Nícolas; Ferreira, Heloisa H.A.

doi:10.1016/j.intimp.2016.07.009

Cited by 27 publications

(16 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cysteine polysulfides are generated from the reaction of H 2 S with cysteine and have an action similar to GSSH . All previous mechanisms concerning the effects of both H 2 S and its products; polysulfides on ROS production and antioxidant gene expression are compatible with the decreased lung lipid peroxides associated with increased lung TAC levels in our results which is also in agreement with Campos et al (2016), Zhang et al (2016), Li et al (2016) and Song and Wang (2016). Kang et al (2017) reported that H 2 S decreased proinflammatory cytokines by suppressing the activation of NF-κB and MAPK dependent signaling and this is compatible with decreased serum IL-6 level with NaHS administration in the current study.…”

Section: Immunohistochemical Assessment Of Inossupporting

confidence: 92%

See 1 more Smart Citation

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

Ali¹,

Abdel-Hamid²,

Toni³

2018

gpb

View full text Add to dashboard Cite

. Hydrogen sulfide (H2S) is gasotransmitter which plays an important role in human physiology. In this study, we aimed to check the effect of H2S treatment on acute lung inflammation (ALI). Thirty-six adult male albino rats were used and divided into: control group, ALI group which was intraperitoneally (i.p.) injected with lipopolysaccharide (LPS) at a dose of 5 mg/kg body weight, ALI group treated by the H2S donor; sodium hydrosulfide (NaHS) at a dose of 10 mg/kg body weight i.p. and ALI group treated by i.p. injection of 80 mg/kg body weight DL- propargylglycine (PAG) which is an inhibitor of endogenous H2S synthesis. Serum was obtained to determine interleukin-6 (IL-6) levels. Lipid peroxides and total antioxidant capacity (TAC) levels were measured in lung. Lung histopathology and expression of inducible nitric oxide synthase (iNOS) were also done. Results showed that NaHS improved lung inflammation through its inhibitory effect on iNOS expression, decreasing the levels of IL-6 and lipid peroxides and increasing TAC levels. But, ALI was exacerbated with PAG administration. In conclusion, the results proved that H2S has a protective effect against LPS induced ALI due to its anti-nitrative, anti-oxidant and anti-inflammatory properties.

show abstract

Section: Immunohistochemical Assessment Of Inossupporting

confidence: 92%

“…The role of H 2 S in acute lung inflammation (ALI) is debatable. Several studies reported that H 2 S gives protection against ALI (Campos et al 2016;Zhang et al 2016). But, Qu et al (2014); Gaddam et al (2016) have found the reverse.…”

Section: Introductionmentioning

confidence: 98%

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

Ali¹,

Abdel-Hamid²,

Toni³

2018

gpb

View full text Add to dashboard Cite

show abstract

“…It appears likely that H 2 S may also in the current study provide its protective effects by directly interfering with at least some of these proteins. With respect to GSH, H 2 S may modulate the balance of reduced (GSH) and oxidized (GSSG) glutathione by promoting the normalization of the GSSG to GSH ratio [ 56 ]. Therefore, antioxidative events may also contribute to H 2 S-mediated protection from VILI.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K/Akt Signaling and Limits Ventilator‐Induced Lung Injury

Spassov

Donus

Ihle

et al. 2017

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The development of ventilator-induced lung injury (VILI) is still a major problem in mechanically ventilated patients. Low dose inhalation of hydrogen sulfide (H2S) during mechanical ventilation has been proven to prevent lung damage by limiting inflammatory responses in rodent models. However, the capacity of H2S to affect oxidative processes in VILI and its underlying molecular signaling pathways remains elusive. In the present study we show that ventilation with moderate tidal volumes of 12 ml/kg for 6 h led to an excessive formation of reactive oxygen species (ROS) in mice lungs which was prevented by supplemental inhalation of 80 parts per million of H2S. In addition, phosphorylation of the signaling protein Akt was induced by H2S. In contrast, inhibition of Akt by LY294002 during ventilation reestablished lung damage, neutrophil influx, and proinflammatory cytokine release despite the presence of H2S. Moreover, the ability of H2S to induce the antioxidant glutathione and to prevent ROS production was reversed in the presence of the Akt inhibitor. Here, we provide the first evidence that H2S-mediated Akt activation is a key step in protection against VILI, suggesting that Akt signaling limits not only inflammatory but also detrimental oxidative processes that promote the development of lung injury.

show abstract

“…Increased expression of iNOS is implicated in a variety of pathological conditions (15,40,48,68) and elevated oxidative-nitrosative stress triggers high iNOS levels (35). CS exposure-induced oxidative-nitrosative stress elevates iNOS expression that results in generation of toxic NO metabolites, which cause severe lung damage (29).…”

Section: Gsno Augmentation Controls Ch-cs-induced Oxidative-nitrosatimentioning

confidence: 99%

Augmentation of S-Nitrosoglutathione Controls Cigarette Smoke-Induced Inflammatory–Oxidative Stress and Chronic Obstructive Pulmonary Disease-Emphysema Pathogenesis by Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function

Bodas

Silverberg

Walworth

et al. 2017

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

show abstract

Increased glutathione levels contribute to the beneficial effects of hydrogen sulfide and inducible nitric oxide inhibition in allergic lung inflammation

Cited by 27 publications

References 17 publications

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K/Akt Signaling and Limits Ventilator‐Induced Lung Injury

Augmentation of S-Nitrosoglutathione Controls Cigarette Smoke-Induced Inflammatory–Oxidative Stress and Chronic Obstructive Pulmonary Disease-Emphysema Pathogenesis by Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function

Contact Info

Product

Resources

About