Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

McMichael, Andrew J.; Sasazuki, Takehiko; McDevitt, Hugh O.; Payne, Rose

doi:10.1002/art.1780200501

Cited by 144 publications

(50 citation statements)

References 19 publications

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“…-DR4 with this disease has been established in whites (4)(5)(6)(7)(8)(9)(10)(11)(12). However, only a limited number of reports on HLA and RA association in other ethnic groups have been published.…”

mentioning

confidence: 99%

HLA and rheumatoid arthritis in the japanese

Nakai¹,

Wakisaka²,

Aizawa³

et al. 1981

Arthritis & Rheumatism

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mentioning

confidence: 99%

HLA and rheumatoid arthritis in the japanese

Nakai¹,

Wakisaka²,

Aizawa³

et al. 1981

Arthritis & Rheumatism

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“…Studies concerning the relationship between DR antigens and disease severity in RA are limited (10)(11)(12)(33)(34)(35)(36). Interpretation of such studies is complica:ed by the fact that different parameters of disease severity (e.g., rate of progression, medication, functional capacity, etc.)…”

Section: Discussionmentioning

confidence: 99%

Seronegative rheumatoid arthritis.

Alarcón

Koopman

Acton

et al. 1982

Arthritis & Rheumatism

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Measurement of serum rheumatoid factor (RF)by conventional methods in patients with rheumatoid arthritis (RA) has repeatedly identified a subpopulation of patients without detectable RF. Previous investigators have consistently confirmed the association of HLA-DR4 with seropositive RA, but studies of seronegative RA have been Limited and contradictory. We studied 140 randomly selected patients from Alabama, all of whom had either classic or definite RA, and we were able to obtain complete HLA typing for 110 of these individuals. Eighty were consistently seropositive (on at least 2 separate occasions) and 30 were consistently seronegative (on at least 3 separate determinations). There was no statistically significant difference between the seronegative RA patients and 123 control subjects in the distribution of DR antigens. In seropositive RA, there was a significant increase in DR4 (PP>O.OOl; relative risk = 0.33).

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“…Recent immunogenetic studies indicate that a common link between the 2 diseases may be the HLADRw4 locus, since the frequency of this allele has been reported to be increased in psoriatic atthritis (34) as well as in rheumatoid arthritis (35,36). Human immune response (Ir) genes appear to be localized near the D locus (37,38).…”

Section: Discussionmentioning

confidence: 99%

Autoimmunity to Collagen

Trentham

Kammer

McCune

et al. 1981

Arthritis & Rheumatism

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Thirty-one patients with seronegative psoriatic arthritis, 27 patients with rheumatoid arthritis, 10 with psoriasis alone, and 20 normal volunteers were studied for autoimmunity to human collagens. Cellular and humoral responses were frequently observed in the 2 groups with arthritis, but the subjects without arthritis did not display reactivity to native collagens. These data demonstrate that collagens function as autoantigens in both psoriatic and rheumatoid arthritis.Psoriatic arthritis is an inflammatory arthritis of unknown etiology that occurs in approximately 5 to 7% of persons with psoriasis (1). The disorder is characterized by an asymmetric distribution of arthritis at onset of disease, the frequent coexistence of dystrophy of the nails and spondylitis, an increased an tissues. Types I and I11 collagens are widely distributed in dermal and organ parenchyma; type I1 collagen appears to be restricted to cartilaginous and ocular tissues; and types IV and V collagens are recently isolated species accounting for a small proportion of the collagen content of some connective tissues (29). In this article, we report that some of these collagens function as cellular and humoral autoantigens in psoriatic arthritis as well as in RA. MATERIALS AND METHODS PatientsPsoriatic arthritis. We studied 3 1 patients with psoriatic arthritis (mean age, 54 years; range, 28-72) who were part of a larger population that we recently analyzed (I).

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Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

Cited by 144 publications

References 19 publications

HLA and rheumatoid arthritis in the japanese

HLA and rheumatoid arthritis in the japanese

Seronegative rheumatoid arthritis.

Autoimmunity to Collagen

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