HLA and rheumatoid arthritis in the japanese

Nakai, Yoshinobu; Wakisaka, Akemi; Aizawa, Mamoru; Itakura, Katsuaki; Nakai, Hidenori; Ohashi, Akiyoshi

doi:10.1002/art.1780240516

Cited by 33 publications

(11 citation statements)

References 11 publications

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“…Serological HLA-DR4 has been reported to be associated with rheumatoid arthritis (RA) in many ethnic groups [1, 2, 3, 4, 5, 6, 7, 8]. Serological HLA-DR1 [7, 9, 10, 11], DR10 [7, 12]and DR14 [13]also have been reported to be associated with RA.…”

Section: Introductionmentioning

confidence: 99%

Association between HLA-DRB1*15 and Japanese Patients with Rheumatoid Arthritis Complicated by Renal Involvement

Tokunaga¹,

Noda²,

Kaneoka³

et al. 1999

Nephron

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We performed serological phenotyping of HLA antigens in 175 patients with rheumatoid arthritis (RA) with (n = 41) and without (n = 134) renal involvement (RI), and DNA typing of HLA class II alleles in 75 patients. Among the patients with RA, the frequency of serologically determined HLA-DR4 was found to be significantly increased (odds ratio: 1.8, confidence interval: 1.3–2.5, p = 2.4×10^–4). In the patients without RI, the frequency of serological DR4 significantly increased (odds ratio: 2.2, confidence interval: 1.6–3.3, p = 2.6×10^–5). On the other hand, among the patients with RI, a serological determinant, DR15, did significantly increase (odds ratio: 2.7, confidence interval: 0.9–8.4, p = 1.2×10^–3) in comparison to the controls. At the DNA level, we found that the association of Japanese RA patients with serological HLA-DR4 was based on that with a genotype of HLA-DRB1*0405 (odds ratio: 2.4, confidence interval: 1.5–4.0, p = 4.4×10^–4) and also found an association of HLA-DRB1*1501 (odds ratio: 2.8, confidence interval: 1.2–6.6, p = 0.017) with RA patients having RI. Our results confirmed the association of HLA-DRB1*04 with RA over the ethnic barrier at the DNA level. Our results also suggested a distinct genetic effect of HLA-DRB1*1501 in the aspect of the susceptibility of RI in RA.

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Section: Introductionmentioning

confidence: 99%

Association between HLA-DRB1*15 and Japanese Patients with Rheumatoid Arthritis Complicated by Renal Involvement

Tokunaga¹,

Noda²,

Kaneoka³

et al. 1999

Nephron

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“…These studies indicate that RA is significantly associated with the molecule HLA-DR4. However, this association is not perfect, in that approximately one-half of RA patients are HLA-DR4 negative (2)(3)(4)22,23).…”

Section: Discussionmentioning

confidence: 99%

“…Although HLA-DR4 is increased in patients with RA, approximately 40% of RA patients are HLA-DR4 negative (3,4,22,23). Some studies suggest that products of genes linked to, but distinct from, those in the HLA-D region may be seen with greater frequency in RA (4,24,25 …”

Section: Collier Et Almentioning

confidence: 99%

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Arthritis & Rheumatism

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Circulating antibodies to native and denatured types I and I1 human and bovine collagens were assayed in patients with rheumatoid arthritis (RA), patients with other rheumatic diseases, and normal individuals. A subgroup of this population was also assayed for reactivity with typing reagents which detect determinants (MT and HLA-DR) present in human immune response gene products. The mean titers of antibodies to each collagen tested were not significantly higher in RA patients when compared with patients who had other rheumatic diseases. Although both MT3 and MT4 were significantly associated with RA, there was no significant association between the anticollagen antibodies and any MT type or HLA-DR4. These studies raise a question concerning

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“…The susceptibility of whites to rheumatoid arthritis (RA) has been associated with HLA-DR4 in patients with seropositive RA (1)(2)(3)(4)(5). Because of racial differences in the frequencies of HLA specificities, however, typing results for whites have not been considered applicable to Japanese patients with RA.…”

Section: To the Editormentioning

confidence: 99%