Increased frequency of G-protein β3-subunit 825 T allele in dialyzed patients with type 2 diabetes

Abstract

The data do not support a role of the hypertension-associated T allele in the genesis of dialysis-dependent end-stage renal failure in general, but are compatible with a specific role of the T allele in the development or progression of diabetic nephropathy.

Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese

“…18,19,26 The development of diabetic nephropathy has only been found in German and Polish patients with type 2 diabetes. 5,9 The total cholesterol levels were significantly higher in Japanese subjects with the T allele. 4 On the contrary, we found that the amount of hyperlipidemia of the CT allele was significantly lower than the CC allele in the Japanese subjects with diabetes.…”

“…4 The 825T allele was reported to be predisposed for end-stage renal disease in type 2 diabetes. 5 The 825T allele frequencies are shown to differ among ethnic groups. 3 The roles of the 825T allele in hypertension, obesity, hyperlipidemia, diabetes, and diabetic complications have been controversial in Caucasians 2,3,5-21 and Japanese.…”

Taq I polymorphism of the vitamin D receptor and risk of severe diabetic retinopathy

“…Interestingly, the G-protein beta 3 subunit gene (GNB3) is located very near to the VDR locus (12q12-q13 and 12q12-q14, respectively), and this family of proteins has been associated with many regulatory functions including cell growth and angiogenesis [53]. One report has showed an association between diabetic nephropathy and a genetic variant in the G-protein beta 3 subunit, C825T polymorphism [54]. However, no association between the latter and DR exists, and, the majority of reports on diabetic nephropathy have not found any association [55].…”

Candidate Genes in Hypertension

“…A polymorphism C3T at nucleotide 825 in exon 10 of the 3 subunit of GTP binding protein (GNB3/C825T) has been identified (Bohm et al, 1997). This polymorphism is associated with enhanced intracellular signal transduction and has been reported to be associated with a variety of cardiovascular risk factors, including hypertension , Schunkert et al, 1998, Benjafield et al, 1998, obesity , Casiglia et al, 2008, diabetes (Bluthner et al, 1999) or dyslipidemia (Ishikawa et al, 2000, Hayakawa et al, 2007. A significantly higher frequency of the T allele has been identified in EH (Beige et al, 1999, Siffert, 1996.…”