Increased frequency of detection of human papillomavirus deoxyribonucleic acid in exfoliated cervical cells during pregnancy

Rando, Robert F.; Lindheim, Steven R.; Hasty, Lisa A.; Sedlacek, Thomas V.; Woodland, Mark; Eder, Catherine

doi:10.1016/0002-9378(89)90231-7

Cited by 109 publications

(44 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several other studies 16,17 show the clearance of HPV infection may accelerate in the third trimester and postpartum. In our study, the HPV infection pattern differed significantly according to the pregnancy trimester.…”

Section: Discussionmentioning

confidence: 96%

“…This study has some limitations because we obtained data from pregnant women; however, our data from pre-vaccination women on the distribution of genital HPV infections in the region where HPV 52 is more prevalent are important for the understanding of the cross-reactivity of a bivalent HPV vaccine. 17,21 Epidemiology of HPV in pregnant Japanese women K Yamasaki et al…”

Section: Discussionmentioning

confidence: 99%

“…One report by Takakuwa et al 15 showed the prevalence of HPV in pregnant Japanese women to be 12.5%. The difference between this report and our results may be because of the detection method used, PCR-reverse hybridization (our study) and PCR-restriction fragment length polymorphism (Takakuwa et al), and the number of detectable HPV genotypes.Several other studies 16,17 show the clearance of HPV infection may accelerate in the third trimester and postpartum. In our study, the HPV infection pattern differed significantly according to the pregnancy trimester.…”

mentioning

confidence: 96%

See 2 more Smart Citations

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

et al. 2011

View full text Add to dashboard Cite

To investigate the pre-vaccination epidemiology of genital human papillomavirus (HPV) infections and genotypes in pregnant Japanese women, we performed Pap smear tests and HPV genotype testing in patients attending Nagasaki University Hospital and collaborating hospitals from August 2007 to July 2010. Serial uterine cervical specimens were obtained from 151 pregnant women. The HPV test was positive on the first visit in 54 women (35.8%; 54/151, average age 30). A total of 49 women (32.5%; 49/151) were infected by at least one high-risk HPV and 5 women were infected by only low-risk HPV. The three most prevalent high-risk HPV genotypes were HPV 52 (31.5%; 17/54), HPV 16 (29.6%; 16/51) and HPV 31 (13.0%; 7/51). The HPV infection pattern (negative, single infection and multiple infection) differed significantly according to the pregnancy trimester (v 2 -test; Po0.01(Pearson)). Among HPV-infected pregnant Japanese women, HPV52 was the most common genotype. The second most common genotype was HPV16, and these two genotypes accounted for B60% of HPV-positive pregnant women. Infection with multiple HPV genotypes was observed more frequently in the first trimester of pregnancy and the pattern of infection changed significantly depending on pregnancy stage. (2011) 56, 313-315; doi:10.1038/jhg.2011 published online 10 February 2011 Keywords: epidemiology; genotype; HPV; infection; pregnancy; uterine cervical neoplasia INTRODUCTION Persistent infections with human papillomavirus (HPV) are recognized as a major cause of cervical cancer. Genital infections with HPV are very common, and these infections are transmitted by sexual contact. 1 In most cases, HPV infections disappear naturally in a relatively short time period and carry only a small risk of disease development; 2-4 however, some investigators believe that pregnancy affects the host immune system; for example, pregnancy is believed to reduce seroreactivity against HPV infection. 5 Estrogen and progesterone have been shown to activate the upstream regulatory region of HPV18 (see ref. 6). Thereby altering HPV clearance rates compared with non-pregnant women. During persistent infection, important factors of disease susceptibility include HPV genotypes and viral characteristics, such as the distribution of each type in the population and the evasive ability against the host's immune system. It is not clear how persistent infection relates to the host, such as how the host immune system reacts against a specific HPV genotype and how sexual behavior in pregnant women affects infection rates. In particular, there are very few data detailing HPV genotype prevalence in pregnant Japanese women. To determine the distribution of HPV infections in pregnant Japanese women, we performed HPV genotype testing. Journal of Human Genetics MATERIALS AND METHODS Study population and sample collectionCytology and HPV DNA test samples were collected by six hospitals that collaborated with Nagasaki University Hospital from August 2007 to July 2010. All pregnant women whose first visit ...

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 96%

See 1 more Smart Citation

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Using a variety of HPV detection techniques, several other studies also have found a significantly higher prevalence of highrisk HPV during pregnancy in comparison with the postpartum period (Rando et al, 1989;Saito et al, 1995;Fife et al, 1999;Yost et al, 1999). Several reasons for this phenomenon have been postulated.…”

Section: Discussionmentioning

confidence: 99%

“…Others reported high regression rates of cervical dysplasia in the postpartum period (Yost et al, 1999). In contrast, high prevalence rates of high-risk HPV have been found in pregnant women (Rando et al, 1989;Saito et al, 1995;Morrison et al, 1996;Fife et al, 1999), although in other studies no differences in HPV prevalence between pregnant and non-pregnant women were seen (Peng et al, 1990;Kemp et al, 1992;De Roda Husman et al, 1995a). In short, the influence of pregnancy on the natural course of infection with high-risk HPV types is not yet known.…”

mentioning

confidence: 94%

High-risk human papillomavirus clearance in pregnant women: trends for lower clearance during pregnancy with a catch-up postpartum

et al. 2002

View full text Add to dashboard Cite

We followed 353 women referred with abnormal cervical cytology in a non-intervention cohort study. In 91 pregnant women we compared high-risk human papilloma virus rates in the subsequent trimesters and postpartum in comparison to 262 nonpregnant women. High-risk human papilloma virus clearance was compared with 179 high-risk human papilloma virus positive non-pregnant women. Our main questions were: (1) do high-risk human papilloma virus rates change during pregnancy?; and (2) is there any difference between high-risk human papilloma virus clearance in pregnant and non-pregnant women? Women were monitored 3 -4 monthly by cytology, colposcopy, and high-risk human papilloma virus testing. The median follow-up time was 33 months (range 3 -74). Non-pregnant women showed prevalence rates of high-risk human papilloma virus of 64, 57, 53, and 50%, respectively, in four subsequent 3-months periods since the start of the study. These high-risk human papilloma virus rates were higher than in the three trimesters of pregnancy, and during the first 3 months postpartum, i.e. 50, 44, 45, and 31%, respectively. Postpartum only, this difference was statistically significant (P=0.004). Paired comparisons of high-risk human papilloma virus prevalence rates of the different trimesters with the postpartum rate showed (McNemar test) decreased rates: first trimester: 18% (P=0.02), second trimester: 13% (P=0.02) and third trimester: 23% (P50.005). Such a phenomenon was not found in non-pregnant women. Pregnant women showed a trend for increased high-risk human papilloma virus clearance during the third trimester and postpartum compared to non-pregnant women (hazard ratios 3.3 (0.8 -13.7) and 4.6 (1.6 -12.8), respectively). These results suggest a lowered immune-response against human papilloma virus during the first two trimesters of pregnancy with a catch-up postpartum. Keywords: human papillomavirus; pregnancy; follow-up study; natural history; prevalence Several epidemiological and biological studies have established the important role of infection with high-risk types of human papilloma virus (HPV) for development of cervical cancer and its precursor lesions. In women with or without abnormal cervical smears a positive high-risk HPV test result indicates an increased risk for development of high grade cervical lesions (Ho et al, 1995;Remmink et al, 1995;Rozendaal et al, 1996Rozendaal et al, , 2000Nobbenhuis et al, 1999). Moreover, in nearly all cervical cancers high-risk HPV types have been detected .The increased prevalence of high grade cervical lesions and cervical cancer in immunocompromised patients, such as AIDS patients and transplant recipients, indicates that persistence of high-risk HPV and consequently HPV-mediated carcinogenesis is related to compromised immunosurveillance (IARC, 1995;Petry et al, 1996;Sun et al, 1997). Pregnancy is believed to alter immune-response in women (Schneider et al, 1987;Sethi et al, 1998). Some authors concluded pregnancy has no effect on CIN (Jain et al, 1997). Others reported high regress...

show abstract

Estrogen and progesterone receptors in cervical human papillomavirus related lesions

Monsonégo

Magdelénat

Catalán

et al. 1991

Intl Journal of Cancer

View full text Add to dashboard Cite

According to recent studies showing that human papillomavirus (HPV) infections can be influenced by sex steroid hormones, we performed estrogen (ER) and progesterone (PgR) receptor assays in fresh frozen biopsies of genital-HPV-related lesions. Seventy-three women with normal cervix, condyloma, low- and high-grade CIN and squamous carcinoma were evaluated in comparison with 15 persons with vulvar and 9 with penile papillomavirus-associated lesions. HPV genotypes were determined by dot-blot hybridization. Non-cervical lesions did not express HR. Condyloma on squamous metaplasia of the cervix and high-grade CIN expressed high levels of HR, particularly PgR (mean 4,086 and 4,518 fmoles/g tissue, respectively). Cervical squamous carcinoma expressed very low concentrations of PgR in a limited number of cases. High levels of PgR were correlated with high-grade CIN (p less than 0.05), HPV16-18-associated lesions (p less than 0.01) and ER were correlated to HPV6-11-related lesions (p less than 0.01). The levels were independent of age, cycle stage and oral contraception. Morphological localization of PgR, using an immunocytochemical method using a monoclonal antibody (MAb) (PR-ICA), showed intense homogeneous staining in the nuclei of the stromal fibroblasts underlying dysplastic epithelium and condyloma on squamous metaplasia. These results suggest that, under in vivo conditions, sex steroid hormones, particularly progesterone, may act indirectly on HPV-infected epithelial cells and be implicated as co-factors in HPV-related cervical neoplasia. They could explain the relative predisposition to malignant transformation of the cervix as compared with vulvar and penile mucosa.

show abstract

Increased frequency of detection of human papillomavirus deoxyribonucleic acid in exfoliated cervical cells during pregnancy

Cited by 109 publications

References 8 publications

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

High-risk human papillomavirus clearance in pregnant women: trends for lower clearance during pregnancy with a catch-up postpartum

Estrogen and progesterone receptors in cervical human papillomavirus related lesions

Contact Info

Product

Resources

About