Increased Fibrinogen to Albumin Ratio in Ischemic Retinal Vein Occlusions

Güçlü, Hande; Özal, Sadık Altan; Gürlü, Vuslat; Özgün, Gülben Sayilan; Özgün, Eray

doi:10.5301/ejo.5000942

Cited by 15 publications

(14 citation statements)

References 32 publications

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“…Accumulating studies have demonstrated that FAR, cooperating albumin and fibrinogen, is an important prognostic predictor in various cancer [16, 17]. Recently, Guclu et al indicated that an elevated FAR was significantly correlated with ischemic retinal vein occlusion [24]. In the study by Karahan et al, FAR was significantly related to SYNTAX Score in predicting the severity of CAD in patients with STEMI [25].…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen-to-Albumin Ratio Predicts Contrast-Induced Nephropathy in Patients after Emergency Percutaneous Coronary Intervention

You

Guo

Lin

et al. 2019

Cardiology Research and Practice

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Background The aim of the present study was to investigate the association between fibrinogen-to-albumin ratio (FAR) with contrast-induced nephropathy (CIN) in patients undergoing emergency percutaneous coronary intervention (PCI). Methods 565 patients with emergency PCI were consecutively enrolled. The primary outcome was CIN defined as either a 25% increase in baseline serum creatinine levels or a 0.5 mg/dL (44 μmol/L) increase in absolute serum creatinine levels within 72 h after the contrast medium exposure. Logistic regression analysis was applied to analyze whether FAR was an independent risk factor for CIN. Results Overall, 29 (5.1%) patients developed CIN. Compared with the patients without CIN, the patients developing CIN had lower albumin (39.79 ± 3.95 vs. 37.14 ± 5.21, P=0.012) and higher fibrinogen levels (3.51 ± 0.94 vs. 4.14 ± 0.96, P < 0.001). In the multivariate logistic analysis, FAR was an independent predictor of CIN (OR = 3.97; 95% CI, 1.61–9.80; P=0.003) along with perihypotension, age >75 years, and LVEF <45%, and 0.106 was the optimal cutoff value of preprocedural FAR to predict CIN. Conclusion Preprocedural levels of FAR were associated with CIN in patients after emergency PCI.

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Section: Discussionmentioning

confidence: 99%

Fibrinogen-to-Albumin Ratio Predicts Contrast-Induced Nephropathy in Patients after Emergency Percutaneous Coronary Intervention

You

Guo

Lin

et al. 2019

Cardiology Research and Practice

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show abstract

Section: Discussionmentioning

confidence: 99%

“…Increased fibrinogen/albumin ratio was found to be associated with inflammation and oxidative stress in several diseases such as ankylosing spondylitis, esophageal squamous cell carcinoma, hepatocellular carcinoma, retinal vein occlusion, sensorineural hearing loss, ischemic stroke, and acute coronary syndrome. [24][25][26][27][28] In the final stage of the coagulation cascade, fibrinogen is converted to fibrin by thrombin. Fibrin clot stops bleeding in the damaged vessel.…”

Section: Discussionmentioning

confidence: 99%

Elevated serum fibrinogen/albumin ratios in patients with acute central serous chorioretinopathy

Limon

Bozkurt

Bulut

et al. 2022

European Journal of Ophthalmology

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Purpose To evaluate the serum fibrinogen/albumin ratios in patients with acute and chronic central serous chorioretinopathy, and healthy control samples. Methods Serum fibrinogen/albumin ratios were assessed in patients with acute (Group-1, 30 eyes) and chronic (Group-2, 30 eyes) central serous chorioretinopathy, and compared with healthy control (Group-3, 30 eyes) samples. Results Fibrinogen/albumin ratios were significantly higher in Group-1 (104.72 ± 12.34) than in Group-2 (75.83 ± 10.06) and in Group-3 (72 ± 9.54) ( p = 0.001). No significant correlation was found between age, CMT, and BCVA with fibrinogen/albumin ratios in the Pearson correlation analysis. In the ROC curve analysis, the most appropriate cut-off value of the fibrinogen/albumin ratio for acute CSCR was ≥87.8 and the optimal cut-off value for the fibrinogen/albumin ratio for chronic CSCR was ≥68.6. Conclusion The fibrinogen/albumin ratio may be useful as an inflammatory biomarker to monitor the systemic inflammatory state during the treatment and follow-up in patients with acute CSCR.

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“…Several studies described that coronary heart disease, such as myocardial infarction, because of its association with cardiovascular risk factors may be an independent risk factor of RVO [ 29 , 30 , 31 ]. Moreover, previous studies showed increased fibrinogen–albumin ratio defined as a marker of inflammation and disease severity in each patient with RVO or SSNHL [ 32 , 33 ]. One case study also reported the patients who suffered from central retinal vein occlusion and sudden deafness [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Sudden Sensorineural Hearing Loss May Increase the Risk of Retinal Vein Occlusion: A Nationwide Cohort Study

Kim

2022

Healthcare

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Sudden sensorineural hearing loss (SSNHL) is thought to be a vascular disease. Retinal vein occlusion (RVO) is an also common ophthalmic vascular disease. Thus, we investigated the potential relationship between these using a retrospective nationwide cohort dataset. We compared 49,584 subjects in the SSNHL and the comparison (non-SSNHL) groups using patients randomly selected via propensity-score matching. We calculated the incidence, survival rate, and hazards ratio (HR) using log-rank test, and Cox proportional hazards regression models. This study examined a total of 375,490.4 person-years in the SSNHL group and 373,698.2 person-years in the comparison group. We found that 673 patients in the SSNHL group (1.8 cases per 1000 person-years) and 592 in the comparison group (1.6 cases per 1000 person-years) developed RVO during the 8-year follow-up period. The adjusted HR of RVO was 1.13 (95% confidence interval [CI] 1.01–1.26). The adjusted HR of developing RVO in SSNHL was the greatest in elderly patients (adjusted HR, 1.21; 95% CI, 1.01–1.46) and male patients (adjusted HR, 1.18; 95% CI, 1.03–1.34). Our findings suggest that clinicians should remain vigilant of the possibility of RVO development in SSNHL patients, specifically elderly male patients.

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Increased Fibrinogen to Albumin Ratio in Ischemic Retinal Vein Occlusions

Abstract: The fibrinogen to albumin ratio is significantly associated with ischemic RVO. Instead of complicated and invasive methods, such as a retinal angiogram, the fibrinogen to albumin ratio could be a useful initial diagnostic test to predict ischemia in RVO.

Cited by 15 publications

References 32 publications

Fibrinogen-to-Albumin Ratio Predicts Contrast-Induced Nephropathy in Patients after Emergency Percutaneous Coronary Intervention

Fibrinogen-to-Albumin Ratio Predicts Contrast-Induced Nephropathy in Patients after Emergency Percutaneous Coronary Intervention

Elevated serum fibrinogen/albumin ratios in patients with acute central serous chorioretinopathy

Sudden Sensorineural Hearing Loss May Increase the Risk of Retinal Vein Occlusion: A Nationwide Cohort Study

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