Increased Expression of Vascular Endothelial Growth Factor in Cyclosporin A‐Induced Gingival Overgrowth in Rats

Çetinkaya, Burcu Özkan; Açıkgöz, Gökhan; Ayas, Bülent; Алиев, Э. С.; Sakallıoğlu, Elif Eser

doi:10.1902/jop.2006.77.1.54

Cited by 25 publications

(31 citation statements)

References 41 publications

(57 reference statements)

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“…Some studies have linked the adverse effects of osteoporosis and osteopenia to use of CsA. 4,5,21,30,31 These features regarding alveolar bone metabolism would be associated with increased osteoclastic activity and reduction of bone formation in the presence of CsA. In this study, the authors suggested that CsA immunosupression might have caused a decrease in periodontal breakdown.…”

Section: Discussionmentioning

confidence: 78%

“…20 Epithelial tissue also showed increased thickness based on an increase of basal stem cell proliferation stimulated by CsA and inflammatory conditions. 21 A study to investigate the effect of periodontal treatment in renal transplant recipients cited that the study results could support the hypothesis that plaque is a significant contributing factor in the development of cyclosporine-induced overgrowth. 22 Additionally, the results show that in patients without periodontal therapy, complications of cyclosporine had adverse effects on oral and periodontal health due to development of clinical overgrowth, in contrast to patients who had periodontal treatment.…”

Section: Discussionmentioning

confidence: 99%

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Previous exposure to Cyclosporine A and periodontal breakdown in rats

Peralta

Pallos

Queiroz

et al. 2015

Archives of Oral Biology

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Previous exposure to Cyclosporine A and periodontal breakdown in rats

Peralta

Pallos

Queiroz

et al. 2015

Archives of Oral Biology

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“…This model is characterized by accumulation of dental plaque and increased infiltration of inflammatory cells that lead to a degradation of periodontal connective tissue and alveolar bone (Keles et al, 2005). In recent years, the effects of CsA therapy on soft tissues of the periodontium have been extensively investigated in vitro (Bartold 1989;Schincaglia et al, 1992) and in vivo (Seymour et al, 1987;Somacarrera et al, 1994;Cetinkaya et al, 2006aCetinkaya et al, , 2006b. It has been reported that 10 mg/kg daily doses of the drug 720 CETINKAYA ET AL TOXICOLOGIC PATHOLOGY provide plasma peak and trough levels of 1000 and 750 ng/ml (Wassef et al, 1985) and blood levels of CsA between 100-400 ng/ml are sufficient to promote immunosupression in animals (rats, dogs, and monkeys) as well as in humans (Fischer and Klinge, 1994).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Cyclosporin A on Alveolar Bone in Rats Subjected to Experimental Periodontal Disease

et al. 2006

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Cyclosporine A (CsA), broadly used in organ transplantation, may contribute to pathogenesis of osteoporosis. The aim of this study was to investigate the effects of CsA on alveolar bone in rats subjected or not to experimental periodontal disease using biochemical, radiographic, and histometric analysis. Forty Wistar rats were divided into 4 equal groups: Group I (Control), Group II (CsA was injected subcutaneously in a daily dose of 10 mg/kg), Group III (Ligature was placed around the mandibular molars), Group IV (Ligature+CsA). After 60 days, rats were decapitated, serum alkaline phosphatase and calcium levels were measured. Radiographic-alveolar bone loss (ABL), histometric-ABL, and percentage of new alveolar bone formation (NABF%) were determined on mandibular molars. Significant increase in serum alkaline phosphatase levels ( p < 0.001), no significant difference in calcium levels were observed ( p > 0.05) in Group IV compared to Group III. Radiographic and histometric-ABL were significantly less ( p < 0.001), NABF% was significantly greater ( p < 0.05) in Group IV than in Group III. No significant difference in any of the parameters between Group II and Group I was found. It can be concluded that in the presence of periodontal disease, CsA treatment may bring out an imbalance in the alveolar bone homeostasis by decreasing resorption and stimulating formation of alveolar bone in rats.

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“…Gingival tissues, removed from the alveolar bone, were placed immediately in a sterile saline solution and frozen at −80°C until biochemical analysis [37]. In brief, before grinding, tissue was blotted, weighed on a microbalance, and placed into a sufficient volume of phosphate buffered saline (PBS; 4°C; pH: 7.0) containing a protease inhibitor (5 μ g/mL aprotinin, 1 mM EDTA) to a dilution of 10 mg tissue/mL PBS plus protease inhibitor solution.…”

Section: Methodsmentioning

confidence: 99%

Biochemical Analysis of Pentraxin 3 and Fibrinogen Levels in Experimental Periodontitis Model

Keleş

Ballı

Çetinkaya

et al. 2012

Mediators of Inflammation

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Objective. Pentraxin 3 (PTX3), newly discovered inflammation marker, is a member of acute-phase proteins. The hypothesis, synthesis of gingival tissue and serum PTX-3 increases in the experimental periodontitis model (with 10-day and 40-day periods), was tested by detecting gingival tissue and serum PTX-3 levels in rats with experimental periodontitis. Methods. Thirty rats were randomly divided into three groups of ten animals each: ligature-induced experimental periodontitis groups (with 10-day (Group1) and 40-day periods (Group2)) and healthy group (Group3). At the end of experimental period, rats were sacrificed, and radiological and histomorphometric analyses were performed on the mandibles. PTX3 levels were measured in gingival tissue and serum samples using ELISA. Plasma fibrinogen levels were measured according to the nephelometric method. Results. Significant alveolar bone resorption and periodontal inflammation were evident in periodontitis groups. Levels of PTX3 in gingival tissue were statistically higher in Group 1 than those in groups 2 and 3 (P < 0.01). No significant difference was found in serum PTX3 levels between experimental periodontitis and control groups (P > 0.05). Plasma fibrinogen levels were significantly increased in the experimental periodontitis groups (P < 0.001). Conclusion. PTX3 seems to be associated with tissue destruction in earlier periods of inflammatory periodontal disease, contrary to the fibrinogen findings.

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Increased Expression of Vascular Endothelial Growth Factor in Cyclosporin A‐Induced Gingival Overgrowth in Rats

Abstract: The results of this study suggest that increased VEGF expression may be associated with the pathogenesis of CsA-induced gingival overgrowth.

Cited by 25 publications

References 41 publications

Previous exposure to Cyclosporine A and periodontal breakdown in rats

Previous exposure to Cyclosporine A and periodontal breakdown in rats

The Effect of Cyclosporin A on Alveolar Bone in Rats Subjected to Experimental Periodontal Disease

Biochemical Analysis of Pentraxin 3 and Fibrinogen Levels in Experimental Periodontitis Model

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