Increased expression of TIPE2 mRNA in PBMCs of patients with ankylosing spondylitis is negatively associated with the disease severity

Zhao, Peiqing; Wang, Lianqing; Xiang, Xinxin; Zhang, Xiaowei; Zhai, Qiaoli; Wu, Xifa; Li, Tao

doi:10.1016/j.humimm.2016.11.001

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…Although they exhibit significant domain homology, their biological functions are versatile (19). Our group documented that TIPE2 serves as a negative regulator in certain inflammatory diseases (20–22). Moreover, TIPE2 can sensitize osteosarcoma cells to cis-platin by downregulating MDR1 transcription, while TIPE1 promotes cervical cancer progression (16, 23).…”

Section: Discussionmentioning

confidence: 99%

TIPE1 Inhibits Breast Cancer Proliferation by Downregulating ERK Phosphorylation and Predicts a Favorable Prognosis

Chen

Liu

et al. 2019

Front. Oncol.

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TIPE1, which acts as a cell death regulator, has emerged as a tumor suppressor in the process of carcinogenesis. However, our recent research demonstrated that it serves as an oncogene in the pathogenesis of cervical cancer, indicating that the role of TIPE1 in carcinogenesis needs to be further evaluated. In this study, we show that TIPE1 is able to inhibit breast cancer cell growth both in vivo and in vitro . Functionally, TIPE1 inhibits cancer cell proliferation preferentially by downregulating ERK phosphorylation. Furthermore, the expression of TIPE1 is decreased in breast cancer tissues compared to matched adjacent tissues, and its expression is positively correlated with patients' lifespan. These data indicate that TIPE1 suppresses breast cancer proliferation by inhibiting the ERK signaling pathway. This study also suggests that TIPE1 could serve as a potential therapeutic target and a diagnostic biomarker for breast cancer.

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Section: Discussionmentioning

confidence: 99%

TIPE1 Inhibits Breast Cancer Proliferation by Downregulating ERK Phosphorylation and Predicts a Favorable Prognosis

Chen

Liu

et al. 2019

Front. Oncol.

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“…Te expression of TIPE2 in the PMBCs of systemic lupus erythematosus patients was also found to be signifcantly decreased and negatively correlated with the SLE disease activity index [12]. However, signifcantly increased levels of TIPE2 expression were found in the PBMCs of patients with ankylosing spondylitis and rheumatoid arthritis [21,22]. We found that the TIPE2 mRNA expression levels in the PBMCs of patients with psoriasis vulgaris were markedly lower than those in healthy volunteers.…”

Section: Discussionmentioning

confidence: 58%

Clinical Significance of Decreased TIPE2 Expression in Peripheral Blood Mononuclear Cells of Patients with Psoriasis Vulgaris

et al. 2023

Dermatologic Therapy

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Psoriasis is an immune system disorder induced by the interaction of the polygenic background and environmental factors. Tumor necrosis factor-α (TNF-α)-induced protein 8-like 2 (TNFAIP8L2, TIPE2), a regulator of immunity, is differentially expressed in tumors, inflammation, and autoimmune diseases. However, to our knowledge, no study has evaluated TIPE2 expression in patients with psoriasis vulgaris. The present case-control study aimed to determine the expression levels of TIPE2 mRNA in the peripheral blood mononuclear cells (PBMCs) of patients with psoriasis vulgaris and analyze the correlation between TIPE2 and other inflammatory cytokine variations in the pathogenesis of psoriasis vulgaris. Thirty-three patients with psoriasis vulgaris and thirty-one healthy volunteers were enrolled from October 2021 to March 2022. The mRNA expression levels of TIPE2, RELA (NF-κb p65), TNF-α, IL-10, IL-6, and IL-1β in PBMCs were determined using qPCR. The severity of psoriasis vulgaris was determined according to the Psoriasis Area and Severity Index (PASI) scores. TIPE2 mRNA expression significantly decreased, while the expression of RELA, TNF-α, IL-10, IL-6, and IL-1β increased in patients with psoriasis vulgaris compared with that in the healthy control group. In addition, the expression levels of TIPE2, RELA, TNF-α, and IL-1β positively correlated with the PASI score. TIPE2 mRNA expression negatively correlated with IL-6 and positively correlated with TNF-α. Moreover, TIPE2 mRNA expression was higher in the active stage than that in the stationary stage. Notably, TNF-α expression levels were higher in patients with psoriasis vulgaris combined with a history of respiratory infection. TIPE2 may contribute to the pathogenesis of psoriasis and be a potential biomarker of psoriasis vulgaris.

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“…It has been demonstrated that the TIPE2 level is reduced in the PBMCs of patients with systemic lupus erythematosus (SLE), and collageninduced arthritis (CIA) mice with a negative correlation with the development of arthritis (35,36). The significant increase in TIPE2 expression in patients with ankylosing spondylitis (AS) is accompanied by a negative correlation with the expression of inflammatory cytokines, which is also speculated to maintain immune homeostasis and inhibit a hyperinflammatory response (37). In chronic hepatitis infection, hepatitis B and C viruses attenuate the expression of TIPE2 and promote the occurrence of chronic hepatitis (38,39).…”

Section: Discussionmentioning

confidence: 99%

Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages

Zou

Zhou

et al. 2021

Front. Immunol.

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A systematic and flexible immunoregulatory network is required to ensure the proper outcome of antiviral immune signaling and maintain homeostasis during viral infection. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2), a novel immunoregulatory protein, has been extensively studied in inflammatory response, apoptosis, and cancer. However, the function of TIPE2 in antiviral innate immunity is poorly clarified. In this study, we reported that the expression of TIPE2 declined at the early period and then climbed up in macrophages under RNA virus stimulation. Knockout of TIPE2 in the macrophages enhanced the antiviral capacity and facilitated type I interferon (IFN) signaling after RNA viral infection both in vitro and in vivo. Consistently, overexpression of TIPE2 inhibited the production of type I IFNs and pro-inflammatory cytokines, and thus promoted the viral infection. Moreover, TIPE2 restrained the activation of TBK1 and IRF3 in the retinoic acid inducible gene-I (RIG-I)-like receptors (RLR) signaling pathway by directly interacting with retinoic acid inducible gene-I (RIG-I). Taken together, our results suggested that TIPE2 suppresses the type I IFN response induced by RNA virus by targeting RIG-I and blocking the activation of downstream signaling. These findings will provide new insights to reveal the immunological function of TIPE2 and may help to develop new strategies for the clinical treatment of RNA viral infections.

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Increased expression of TIPE2 mRNA in PBMCs of patients with ankylosing spondylitis is negatively associated with the disease severity

Cited by 8 publications

References 31 publications

TIPE1 Inhibits Breast Cancer Proliferation by Downregulating ERK Phosphorylation and Predicts a Favorable Prognosis

TIPE1 Inhibits Breast Cancer Proliferation by Downregulating ERK Phosphorylation and Predicts a Favorable Prognosis

Clinical Significance of Decreased TIPE2 Expression in Peripheral Blood Mononuclear Cells of Patients with Psoriasis Vulgaris

Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages

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