Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patients

Harada, Ken; Shibata, Rei; Ouchi, Noriyuki; Tokuda, Yoshiyuki; Funakubo, Hiroshi; Suzuki, Mayu; Kataoka, Tetsuro; Nagao, Tomoyuki; Okumura, Satoshi; Shinoda, Norihiro; Kato, Bunichi; Sakai, Shin’ichi; Kato, Masataka; Marui, Nobuyuki; Ishii, Hideki; Amano, Tetsuya; Murohara, Toyoaki

doi:10.1016/j.atherosclerosis.2016.07.003

Cited by 42 publications

(35 citation statements)

References 37 publications

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“…These findings are in accordance with the data by Fain et al (2008) who showed markedly higher omentin mRNA expression in epicardial as compared with subcutaneous fat. A direct comparison of EAT omentin mRNA expression between subjects with and without CAD has thus far been performed in 2 studies on East Asian populations with opposite results alleged to differences in study populations including anthropometric parameters and the prevalence of diabetes mellitus (Du et al 2016, Harada et al 2016. Our data on a Caucasian population confirm the findings by Harada et al (2016) who showed increased omentin mRNA expression in EAT of subjects with CAD.…”

Section: Discussionsupporting

confidence: 74%

Changes in Omentin Levels and Its mRNA Expression in Epicardial Adipose Tissue in Patients Undergoing Elective Cardiac Surgery: the Influence of Type 2 Diabetes and Coronary Heart Disease

Matloch

Kratochvílová²,

Cinkajzlová³

et al. 2018

Physiol Res

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Omentin is a protein produced by numerous tissues including adipose tissue. Its concentrations are decreased in patients with obesity, type 2 diabetes mellitus (DM) and coronary artery disease (CAD). Experimental studies suggest that omentin may have anti-inflammatory and insulin-sensitizing properties. In the present study, we measured circulating omentin levels and its mRNA expression in epicardial and subcutaneous fat, intercostal and heart muscle before and after elective cardiac surgery in patients with CAD (CAD+, DM-, n=18), combination of CAD and DM (CAD+, DM+, n=9) or with none of these conditions (CAD-, DM-, n=11). The groups did not differ in baseline anthropometric and biochemical characteristics with the exception of higher blood glucose and HBA1c in CAD+, DM+ group. Baseline circulating omentin levels tended to be lower in CAD+, DM- and CAD+, DM+ groups as compared to CAD-, DM- group and cardiac surgery increased its concentration only in CAD-, DM- group. The change in serum omentin levels during surgery inversely correlated with epicardial fat thickness. While baseline omentin mRNA expression did not differ among the groups in any of the studied tissues, its increase after surgery was present only in subcutaneous fat in CAD-, DM- and CAD+, DM- groups, but not in CAD+, DM+ group. Intercostal muscle omentin mRNA expression increased after surgery only in CAD-, DM- group. In conclusion, cardiac surgery differentially affects omentin levels and subcutaneous fat and skeletal muscle mRNA expression in patients without coronary artery disease and diabetes as compared to patients with these conditions.

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Section: Discussionsupporting

confidence: 74%

Changes in Omentin Levels and Its mRNA Expression in Epicardial Adipose Tissue in Patients Undergoing Elective Cardiac Surgery: the Influence of Type 2 Diabetes and Coronary Heart Disease

Matloch

Kratochvílová²,

Cinkajzlová³

et al. 2018

Physiol Res

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“…Prior studies have shown that plasma levels of ITLN1 are low in patients with CAD [12, 19]. The plasma levels of ITLN1 prior to acute ischemia in our study were also lower in patients with known CAD, although this difference was not statistically significant.…”

Section: Discussioncontrasting

confidence: 73%

“…Given the proximity of our cardiac biopsy samples to epicardial adipose tissue (EAT), which has also been shown to express ITLN1 [8, 19], we further wanted to characterize the expression of ITLN1 in this compartment. Clinical studies have demonstrated that the amount of EAT correlates with visceral adipose tissue (VAT), and is increased in aging and obesity [34, 35].…”

Section: Resultsmentioning

confidence: 99%

“…Studies have shown that the epicardial fat, a special type of visceral fat, expresses high amounts of ITLN1 and this expression may be related to underlying CAD [19, 20]. Early studies on the global expression of ITLN1 demonstrated that this adipokine has low levels of expression in other organs including the heart [7] but further studies in humans have been limited given the difficulty of obtaining human heart tissue.…”

Section: Introductionmentioning

confidence: 99%

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Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia

Saddic

Nicoloro

Gupta

et al. 2017

Cardiovasc Diabetol

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BackgroundOmentin-1, also known as Intelectin-1 (ITLN1), is an adipokine with plasma levels associated with diabetes, obesity, and coronary artery disease. Recent studies suggest that ITLN1 can mitigate myocardial ischemic injury but the expression of ITLN1 in the heart itself has not been well characterized. The purpose of this study is to discern the relationship between the expression pattern of ITLN1 RNA in the human heart and the level of circulating ITLN1 protein in plasma from the same patients following myocardial ischemia.MethodsA large cohort of patients (n = 140) undergoing elective cardiac surgery for aortic valve replacement were enrolled in this study. Plasma and left ventricular biopsy samples were taken at the beginning of cardiopulmonary bypass and after an average of 82 min of ischemic cross clamp time. The localization of ITLN1 in epicardial adipose tissue (EAT) was also further characterized with immunoassays and cell fate transition studies.ResultsmRNA expression of ITLN1 decreases in left ventricular tissue after acute ischemia in human patients (mean difference 280.48, p = 0.001) whereas plasma protein levels of ITLN1 increase (mean difference 5.24, p < 0.001). Immunohistochemistry localized ITLN1 to the mesothelium or visceral pericardium of EAT. Epithelial to mesenchymal transition in mesothelial cells leads to a downregulation of ITLN1 expression.ConclusionsMyocardial injury leads to a decrease in ITLN1 expression in the heart and a corresponding increase in plasma levels. These changes may in part be due to an epithelial to mesenchymal transition of the cells that express ITLN1 following ischemia. Trial Registration Clinicaltrials.gov ID: NCT00985049Electronic supplementary materialThe online version of this article (doi:10.1186/s12933-017-0567-x) contains supplementary material, which is available to authorized users.

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“…Ekspresja mRNA omentyny w nasierdziowej tkance tłuszczowej może mieć wpływ na rozwój i przebieg choroby wieńcowej. Zmniejszenie stężenia omentyny-1 we krwi wykazano u pacjentów z ostrym zespołem wieńcowym i dławicą piersiową [7,8]. Inną zależność wykazały badania prowadzone przez Saely i wsp.…”

Section: Rola Omentyny W Chorobach Układu Krążeniaunclassified

Omentin – a novel biomarker in medicine? (Part 2)

Waluga¹,

Komosińska-Vassev²,

Szczepański³

et al. 2018

Farm Pol.

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Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patients

Cited by 42 publications

References 37 publications

Changes in Omentin Levels and Its mRNA Expression in Epicardial Adipose Tissue in Patients Undergoing Elective Cardiac Surgery: the Influence of Type 2 Diabetes and Coronary Heart Disease

Changes in Omentin Levels and Its mRNA Expression in Epicardial Adipose Tissue in Patients Undergoing Elective Cardiac Surgery: the Influence of Type 2 Diabetes and Coronary Heart Disease

Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia

Omentin – a novel biomarker in medicine? (Part 2)

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