Increased expression of STAT3 and SOCS3 in placenta from hyperglycemic rats

Justina, Vanessa Dela; Martín, Sebastián San; López-Espíndola, Daniela; Bressan, Alecsander F.; Freitas, Raiany Alves de; Passos, Ana Maria; Varas, Juan; Lima, Victor Vitorino; Giachini, Fernanda R.

doi:10.4081/ejh.2019.3054

Cited by 3 publications

(1 citation statement)

References 38 publications

(56 reference statements)

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“…3D-G). These staining-patterns are consistent with a previous IHC-based study showing increased SOCS3 expression in the junctional zone 51 of hyperglycemic rat placentas.…”

Section: Il-6 May Induce Placental Immunomodulation Via Socs3supporting

confidence: 92%

Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

Hansen,

Krautz,

Rago

et al. 2024

Nat Commun

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The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lung- inflammation, we characterize the response to maternal pulmonary lipopolysaccharide exposure across 24 h in maternal and fetal organs using multi-omics, imaging and integrative analyses. Unlike maternal organs, which mount strong inflammatory immune responses, the placenta upregulates immuno-modulatory genes, in particular the IL-6 signaling suppressor Socs3. Similarly, we observe no immune response in the fetal liver, which instead displays metabolic changes, including increases in lipids containing docosahexaenoic acid, crucial for fetal brain development. The maternal liver and plasma display similar metabolic alterations, potentially increasing bioavailability of docosahexaenoic acid for the mother and fetus. Thus, our integrated temporal analysis shows that systemic inflammation in the mother leads to a metabolic perturbation in the fetus.

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“…3D-G). These staining-patterns are consistent with a previous IHC-based study showing increased SOCS3 expression in the junctional zone 51 of hyperglycemic rat placentas.…”

Section: Il-6 May Induce Placental Immunomodulation Via Socs3supporting

confidence: 92%

Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

Hansen,

Krautz,

Rago

et al. 2024

Nat Commun

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Interleukin-10 in the Vasculature: Pathophysiological Implications

Freitas

Lima

Bomfim

et al. 2022

CVP

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Interleukin-10 (IL-10) is an important immunomodulatory cytokine, initially characterized as an anti-inflammatory agent released by immune cells during infectious and inflammatory processes. IL-10 exhibits biological functions that extend to the regulation of different intracellular signaling pathways directly associated with vascular function. This cytokine plays a vital role in vascular tone regulation through the change of important proteins involved in vasoconstriction and vasodilation. Numerous investigations covered here have shown that therapeutic strategies inducing IL-10 result in anti-inflammatory, anti-hypertrophic, antihyperplastic, anti-apoptotic and antihypertensive effects. This non-systematic review summarizes the modulating effects mediated by IL-10 in vascular tissue, particularly on vascular tone, and the intracellular pathway induced by this cytokine. We also highlight the advances in IL-10 manipulation as a therapeutic target in different cardiovascular pathophysiologies, including the physiological implications in animals and humans. Finally, the review illustrates current and potential future perspectives of the potential use of IL-10 in clinical trials, based on the clinical evidence.

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Twenty years of histochemistry in the third millennium, browsing the scientific literature

Pellicciari¹

2020

Eur J Histochem

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Over the last twenty years, about 240,000 articles where histochemical techniques were used have been published in indexed journals, and their yearly number has progressively increased. The histochemical approach was selected by researchers with very different scientific interests, as the journals in which these articles were published fall within 140 subject categories. The relative proportion of articles in some of these journal categories did change over the years, and browsing the table of contents of the European Journal of Histochemistry, as an example of a strictly histochemical journal, it appeared that in recent years histochemical techniques were preferentially used to mechanistically investigate natural or experimentally induced dynamic processes, with reduced attention to purely descriptive works. It may be foreseen that, in the future, histochemistry will be increasingly focused on studying the molecular pathways responsible for cell differentiation, the maintenance or loss of the differentiated state, and tissue regeneration.

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Increased expression of STAT3 and SOCS3 in placenta from hyperglycemic rats

Cited by 3 publications

References 38 publications

Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

Interleukin-10 in the Vasculature: Pathophysiological Implications

Twenty years of histochemistry in the third millennium, browsing the scientific literature

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