Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation
Signe Schmidt Kjølner Hansen,
Robert Krautz,
Daria Rago
et al.
Abstract:The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lung- inflammation, we characterize the response to maternal pulmonary lipopolysaccharide exposure across 24 h in maternal and fetal organs using multi-omics, imaging and integrative analyses. Unlike maternal organs, which mount strong inflammatory immune responses, the place… Show more
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